Konfigurering och ibruktagning av KNX system

Detta examensarbete behandlar grunderna i KNX samt programmering av KNX enheter med datorprogrammet ETS 4. I arbetet beskrivs hur KNX systemet fungerar, hur det är uppbyggt och de olika överföringsmedium som kan användas då KNX enheter kommunicerar. Jag beskriver också hur ETS 4 installeras på datorn och hur man kommer igång med programmeringen av KNX enheterna. Inför detta examensarbete har jag studerat en del av ABB:s KNX enheter samt deras funktioner och konfigurationsmöjligheter. Syftet med detta examensarbete är att skapa en liten handbok för hur ett KNX system är uppbyggt samt hur KNX enheterna programmeras med ETS 4.Tämä opinnäytetyö käsittelee KNX:n perusteita ja KNX-laitteiden ohjelmointia ETS 4 tietokoneohjelman avulla. Työssä kuvaillaan, miten KNX-järjestelmä toimii, millä tavalla se on rakennettu sekä mitä eri siirtomedioita voidaan käyttää KNX-laitteiden viestinnässä. Työssä kuvaillaan myös, miten ETS-ohjelma asennetaan tietokoneella ja miten päästään aloittamaan KNX-laitteiden ohjelmointi. Ennen tätä opinnäytetyötä kirjoittaja on opiskellut ABB:n KNX-laitteita sekä niiden toimintoja ja konfiguraatiomahdollisuuksia. Opinnäytetyön tarkoituksena on tehdä pieni käsikirja, joka kertoo, miten KNX- järjestelmä on rakennettu sekä millä tavalla KNX-laitteet ohjelmoidaan ETS 4:llä.In this thesis I deal with the basics of KNX as well as the programming of KNX devices with the computer software ETS 4. In the thesis I describe how the KNX system works, how it is built and the different communication media that are used for communication between KNX devices. I also describe how ETS 4 is installed on a personal computer and how to get started with the programming of the KNX devices. When preparing for this thesis I studied a part of ABB’s KNX devices, their functions as well as their configuration possibilities. The purpose of this thesis is to create a small manual that can be used to see how a KNX system is built and to check how KNX devices are programmed with ETS 4

Ohutlevytuotteen välivarastoinnin ja identifioinnin menetelmäkehitystyö

Työssä tutkittiin ohutlevytuotteiden identifioimisen ja välivarastoinnin automatisointia Stofix Montage Teamin toimeksiannosta. Työn tavoitteena oli kehittää menetelmäratkaisut pakattujen ohutlevytuotteiden identifioimiseen ja niiden kuljettamiseen välivarastoon. Stofixilla ohutlevytuotteet identifioidaan ja välivarastoidaan manuaalisesti, mikä sitoo työntekijän samanaikaisesti kahteen eri työvaiheeseen. Tuotteet identifioidaan käyttäen tussikynää ja teippiä ja se on havaittu yrityksessä hitaaksi identifiointimenetelmäksi. Välivarastoidessa pakatut tuotteet nostetaan seinään vasten varastointitilaan, mikä altistaa tuotteet virumiselle ja vaurioitumiselle. Lisäksi tuotteen painon ylittäessä työturvallisuusmääräyksen salliman maksimipainon joutuu työvaiheeseen sitomaan kaksi työntekijää. Ongelmanratkaisuun ja kehitystyöhön käytettiin aikaisempien vuosien robotiikkaa käsitteleviä insinööritöitä sekä automatisoinnin suunnitteluohjekirjoja. Välivarastoinnin ja identifioinnin nykyinen prosessi analysoitiin lähtötilanne-, prosessi- ja kappaleanalyysin pohjalta, jonka kautta menetelmille valittiin komponentteja vertailua varten. Projektin läpiviemiseen käytettiin projektihallinnan aikataulu- ja projekti-suunnitelmapohjia sekä budjettilaskelman muodostavia hintavertailuja tarjouspyynnöistä. Analyysin perusteella menetelmän toteuttamiseen valittiin kattoon sijoitettava lineaarijohteella paikoittava kuusiakselinen robottikäsivarsi ja automaattisesti tulostava tarroituskone. Työn lopputulokseksi tuli robotiikalla ja alipainetarttujalla tehtävä tuotteiden välivarastointi sekä automaattisella tarroituskoneella tapahtuva identifiointi. Työ onnistui odotetusti, ja se tuotti yritykselle robottikäsivarren, alipainetarttujan ja tarroituskoneen komponenttivalinnat budjetoinnin lisäksi. Yritys voi hyödyntää työn tuloksia, kun tuotantoprosessia aletaan automatisoida. Työn jatkokehityskohteena voidaan tehdä robottisolun turvallisuussuunnitelma ja ohjelmointi, lineaarijohteen kompo-nenttivalinnat ja robotin kiinnitysrakenteen mekaniikkasuunnittelu

Capturing molecular structural dynamics by 100 ps time-resolved X-ray absorption spectroscopy

An experimental set-up for time-resolved X-ray absorption spectroscopy with 100 ps time resolution at beamline NW14A at the Photon Factory Advanced Ring is presented

MR perfusion imaging by alternate slab width inversion recovery arterial spin labeling (AIRASL): a technique with higher signal-to-noise ratio at 3.0 T

Object: To propose a new arterial spin labeling (ASL) perfusion-imaging method (alternate slab width inversion recovery ASL: AIRASL) that takes advantage of the qualities of 3.0 T. Materials and methods: AIRASL utilizes alternate slab width IR pulses for labeling blood to obtain a higher signal-to-noise ratio (SNR). Numerical simulations were used to evaluate perfusion signals. In vivo studies were performed to show the feasibility of AIRASL on five healthy subjects. We performed a statistical analysis of the differences in perfusion SNR measurements between flow-sensitive alternating inversion recovery (FAIR) and AIRASL. Results: In signal simulation, the signal obtained by AIRASL at 3.0 and 1.5 T was 1.14 and 0.85%, respectively, whereas the signal obtained by FAIR at 3.0 and 1.5 T was 0.57 and 0.47%, respectively. In an in vivo study, the SNR of FAIR (3.0 T) and FAIR (1.5 T) were 1.73 ± 0.49 and 1.02 ± 0.20, respectively, whereas the SNRs of AIRASL (3.0 T) and AIRASL (1.5 T) were 3.93 ± 1.65 and 1.34 ± 0.31, respectively. SNR in AIRASL at 3.0 T was significantly greater than that in FAIR at 3.0 T. Conclusion: The most significant potential advantage of AIRASL is its high SNR, which takes advantage of the qualities of 3.0 T. This sequence can be easily applied in the clinical setting and will enable ASL to become more relevant for clinical application. © 2012 ESMRMB.Article in Press エンバーゴ設定 Thesis of Fujiwara, Yasuhiro / 藤原 康博 博士学位論文(金沢大学 / 大学院医薬保健学総合研究科

Real-world effectiveness and safety analysis of carfilzomib-lenalidomide-dexamethasone and carfilzomib-dexamethasone in relapsed/refractory multiple myeloma: a multicenter retrospective analysis

Background: Little is known about the real-world survival benefits and safety profiles of carfilzomib-lenalidomide-dexamethasone (KRd) and carfilzomib-dexamethasone (Kd). Methods: We performed a retrospective analysis to evaluate their efficacy and safety in 157 patients registered in the Kansai Myeloma Forum database. Results: A total of 107 patients received KRd. Before KRd, 99% of patients had received bortezomib (54% were refractory disease), and 82% had received lenalidomide (57% were refractory disease). The overall response rate (ORR) was 68.2%. The median progression-free survival (PFS) and overall survival (OS) were 8.8 and 29.3 months, respectively. Multivariate analysis showed that reduction of the carfilzomib dose and non-IgG M protein were significantly associated with lower PFS and reduction of the carfilzomib dose and refractoriness to prior bortezomib-based regimens were significantly associated with lower OS. A total of 50 patients received Kd. Before Kd, 96% of patients had received bortezomib (54% were refractory disease). The ORR was 62.0%. The median PFS and OS were 7.1 and 20.9 months, respectively. Based on the multivariate analysis, reduction of the carfilzomib dose and International Staging System Stage III (ISS III) were significantly associated with lower PFS. Grade III or higher adverse events were observed in 48% of KRd cases and 54% of Kd cases. Cardiovascular events, cytopenia, and infections were frequent, and 4 KRd patients died due to heart failure, arrhythmia, cerebral hemorrhage, and pneumonia. Conclusion: Our analysis showed that an adequate dose of carfilzomib is important for achieving the best survival benefits in a real-world setting. Adverse effects after KRd and Kd therapy should also be considered

Monocyte or white blood cell counts and β₂ microglobulin predict the durable efficacy of daratumumab with lenalidomide

BACKGROUND: Daratumumab is one of the most widely used treatments for relapsed/refractory multiple myeloma (MM) patients. However, not all patients achieve a lasting therapeutic response with daratumumab. OBJECTIVES: We hypothesized that a durable response to daratumumab could be predicted by the balance between the MM tumor burden and host immune status. DESIGN: We conducted a retrospective study using the real-world data in the Kansai Myeloma Forum (KMF) database. METHODS: We retrospectively analyzed 324 relapsed/refractory MM patients who were treated with daratumumab in the KMF database. RESULTS: In this study, 196 patients were treated with daratumumab, lenalidomide, and dexamethasone (DLd) regimen and 128 patients were treated with daratumumab, bortezomib, and dexamethasone (DBd) regimen. The median age at treatment, number of prior treatment regimens and time-to-next-treatment (TTNT) were 68, 4 and 8.02 months, respectively. A multivariate analysis showed that the TTNT under the DLd regimen was longer with either higher monocyte counts (analysis 1), higher white blood cell (WBC) counts (analysis 2), lower β2 microglobulin (B2MG < 5.5 mg/L) or fewer prior regimens (<4). No parameters were correlated with TTNT under the DBd regimen. CONCLUSION: We propose a simple scoring model to predict a durable effect of the DLd regimen by classifying patients into three categories based on either monocyte counts (0 points for ⩾200/μl; 1 point for <200/μl) or WBC counts (0 points for ⩾3500/μl; 1 point for <3500/μl) plus B2MG (0 points for <5.5 mg/L; 1 point for ⩾5.5 mg/L). Patients with a score of 0 showed significantly longer TTNT and significantly better survival compared to those with a score of 1 or 2 (both p < 0.001). To confirm this concept, our results will need to be validated in other cohorts

The first success of glass eel production in the world: basic biology on fish reproduction advances new applied technology in aquaculture

The eel has long been esteemed as an important food fish in the world, especially in Japan, and has been used as an experimental fish for many fields of fish physiology. However, the decreases in eel resources have been a serious concern in recent years. The catches of glass eels as seedlings for aquaculture have shown a long-term decrease in both Europe and East Asia. To increase eel resources, the development of techniques for artificial induction of maturation and spawning and rearing their larvae have been eagerly desired. Recent progress of reproductive physiology of fish, especially mechanisms of oocyte maturation and ovulation in female and of spermatozoa maturation in male, facilitate to establish techniques for hormonal induction of maturation and spawning in sexually immature eels. With persistent effort to development of rearing techniques of larvae, we have first succeeded to produce glass eel. These applied techniques are may contribute to understand the basic reproductive physiology of the eel