The ATLAS Trigger/DAQ Authorlist, version 1.0

This is a reference document giving the ATLAS Trigger/DAQ author list, version 1.0 of 20 Nov 2008

The ATLAS Trigger/DAQ Authorlist, version 2.0

This is the ATLAS Trigger/DAQ Authorlist, version 2.0, 31 July 200

The ATLAS Trigger/DAQ Authorlist, version 3.1

This is the ATLAS Trigger/DAQ Authorlist, version 3.1, 17 September 200

The ATLAS Trigger/DAQ Authorlist, version 3.0

This is the ATLAS Trigger/DAQ Authorlist, version 3.0, 11 September 200

643 Autopsy review of chimeric-antigen receptor T cell therapy: a single institution experience

Background Our institution has treated over 300 patients with chimeric antigen receptor (CAR) T-cell immunotherapy (CAR T-cell therapy) since 2013. Phase I and II trials were primarily based on heavily treated patients with B cell acute lymphoblastic leukemia (B-ALL), aggressive diffuse large B cell lymphoma (DLBCL), and multiple myeloma (MM) who had failed multiple lines of prior chemotherapy and/or hematopoietic stem cell transplantation (HSCT). In these relapsed and/or refractory patients, CAR-T therapy resulted in complete remission in 93% of B-ALL, 60% of DLBCL, and ~80% of MM. Our Pathology Group at Fred Hutch have reviewed and diagnosed various patients with interesting relapse or complications as a result of CAR T-cell therapy. Here we present a retrospective review of autopsies from CAR T-cell therapy. Methods A search for all autopsies conducted on patients from Seattle Cancer Care Alliance/University of Washington Medical Center was performed using the keywords ‘CAR T’ and ‘Chimeric-antigen’. Our inclusion criteria were patients treated with CAR T-cell therapy. Pathology and clinical records were reviewed for cause of death, disease and treatment timelines, microbiology data, cytokine levels, other pathology biopsies, and pertinent laboratory values. Histologic tissues were reviewed. Results Twelve autopsies were performed since 2013. Patient characteristics and causes of death are summarized in table 1. The most common cause of death was due to infectious causes (n=6). Two patients (Patients 10 and 11) had cardiovascular related deaths. Six patients (Patients 1, 2, 6, 7, 10, 12) suffered from CRS in their post-infusion course, four of whom (Patients 1, 2, 7, 10) had CRS directly attributed as the cause of death. CRS was further complicated by immune effector cell-associated neurotoxicity syndrome (ICANS) in 5 patients (Patients 1, 5, 6, 7, and 12). CRS with ICANS was the second most common cause of death in patients treated with CAR T-cells. Three patients (Patients 1, 4, 9) had progression of disease that attributed to cause of death. Conclusions CAR T-cell therapy is a highly effective treatment even for patients who have relapsed and/or refractory disease. Post-therapy complications range in severity and may be fatal in rare instances as in the patients summarized in this study. Infection, CRS with ICANS are the most common causes of death in our single institution study. Ethics Approval The study was approved by Fred Hutchinson Cancer Research Center’s Institutional Review Board, approval number 1837 Consent Written informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.

The description of a so-called cytokine storm in patients with COVID-19 has prompted consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However, direct systematic comparisons of COVID-19 with other critical illnesses associated with elevated cytokine concentrations have not been reported. In this Rapid Review, we report the results of a systematic review and meta-analysis of COVID-19 studies published or posted as preprints between Nov 1, 2019, and April 14, 2020, in which interleukin-6 concentrations in patients with severe or critical disease were recorded. 25 COVID-19 studies (n=1245 patients) were ultimately included. Comparator groups included four trials each in sepsis (n=5320), cytokine release syndrome (n=72), and acute respiratory distress syndrome unrelated to COVID-19 (n=2767). In patients with severe or critical COVID-19, the pooled mean serum interleukin-6 concentration was 36·7 pg/mL (95% CI 21·6-62·3 pg/mL; I2=57·7%). Mean interleukin-6 concentrations were nearly 100 times higher in patients with cytokine release syndrome (3110·5 pg/mL, 632·3-15 302·9 pg/mL; p<0·0001), 27 times higher in patients with sepsis (983·6 pg/mL, 550·1-1758·4 pg/mL; p<0·0001), and 12 times higher in patients with acute respiratory distress syndrome unrelated to COVID-19 (460 pg/mL, 216·3-978·7 pg/mL; p<0·0001). Our findings question the role of a cytokine storm in COVID-19-induced organ dysfunction. Many questions remain about the immune features of COVID-19 and the potential role of anti-cytokine and immune-modulating treatments in patients with the disease

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.

The description of a so-called cytokine storm in patients with COVID-19 has prompted consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However, direct systematic comparisons of COVID-19 with other critical illnesses associated with elevated cytokine concentrations have not been reported. In this Rapid Review, we report the results of a systematic review and meta-analysis of COVID-19 studies published or posted as preprints between Nov 1, 2019, and April 14, 2020, in which interleukin-6 concentrations in patients with severe or critical disease were recorded. 25 COVID-19 studies (n=1245 patients) were ultimately included. Comparator groups included four trials each in sepsis (n=5320), cytokine release syndrome (n=72), and acute respiratory distress syndrome unrelated to COVID-19 (n=2767). In patients with severe or critical COVID-19, the pooled mean serum interleukin-6 concentration was 36·7 pg/mL (95% CI 21·6-62·3 pg/mL; I2=57·7%). Mean interleukin-6 concentrations were nearly 100 times higher in patients with cytokine release syndrome (3110·5 pg/mL, 632·3-15 302·9 pg/mL; p<0·0001), 27 times higher in patients with sepsis (983·6 pg/mL, 550·1-1758·4 pg/mL; p<0·0001), and 12 times higher in patients with acute respiratory distress syndrome unrelated to COVID-19 (460 pg/mL, 216·3-978·7 pg/mL; p<0·0001). Our findings question the role of a cytokine storm in COVID-19-induced organ dysfunction. Many questions remain about the immune features of COVID-19 and the potential role of anti-cytokine and immune-modulating treatments in patients with the disease

Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. I: Structuring centers for the multidisciplinary clinical administration and management of CAR-T cell therapy patients

Chimeric antigen receptor T-cells (CAR-T cells) are a new modality of oncological treatment which has demonstrated impressive response in refractory or relapsed diseases, such as acute lymphoblastic leukemia (ALL), lymphomas, and myeloma but is also associated with unique and potentially life-threatening toxicities. The most common adverse events (AEs) include cytokine release syndrome (CRS), neurological toxicities, such as the immune effector cell-associated neurotoxicity syndrome (ICANS), cytopenias, infections, and hypogam-maglobulinemia. These may be severe and require admission of the patient to an intensive care unit. However, these AEs are manageable when recognized early and treated by a duly trained team. The objective of this article is to report a consensus compiled by specialists in the fields of oncohematology, bone marrow transplantation, and cellular therapy describing recommendations on the Clinical Centers preparation, training of teams that will use CAR-T cells, and leading clinical questions as to their use and the management of potential complications. (C) 2021 Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espana, S.L.U