Chemometric profile & antimicrobial activities of leaf extract of <i>Calotropis procera</i> and <i>Calotropis gigantea</i>

<p><i>Calotropis procera</i> and <i>Calotropis gigantea</i> are medicinal plant having therapeutic value. The leaf extracts of <i>C. procera</i> have been investigated, its pharmacological actions in detail and leaf extracts of <i>C. gigantea</i> were not studied till date. The objective of present work was to find the bioactive constituents present in the ethanolic leaf extract of <i>C. procera</i> and <i>C. gigantea</i> to evaluate their antibacterial and anifungal activities. The major phytochemical groups in <i>C. procera</i> ethanolic leaf extracts were fatty acid ethyl ester (21.36%), palmitic acid ester (10.24%), linoleic acid (7.43%) and amino acid (8.10%) respectively, whereas ethanolic leaf extracts of <i>C. gigantea</i> contain palmitic acid (46.01%), diterpene (26.53%), triterpene (17.39%), linoleic acid (5.13%) as the major phytochemical groups. Ethanol extract of <i>C. procera</i> leaves showed the highest inhibition (11 mm) against <i>Escherichia coli</i>, while ethanolic extract of <i>C. gigantea</i> leaves inhibited Klebsiella (20 mm). These findings will use in new directions in pharmacological investigations.</p