PAMS: Platform for Artificial Market Simulations

This paper presents a new artificial market simulation platform, PAMS: Platform for Artificial Market Simulations. PAMS is developed as a Python-based simulator that is easily integrated with deep learning and enabling various simulation that requires easy users' modification. In this paper, we demonstrate PAMS effectiveness through a study using agents predicting future prices by deep learning.Comment: 7page

The investigation into the Ice shelf-Ocean Interaction of East Antarctica with special focusing on the Ocean Circulation

The Tenth Symposium on Polar Science/Special session: [S] Future plan of Antarctic research: Towards phase X of the Japanese Antarctic Research Project (2022-2028) and beyond, Tue. 3 Dec. / 2F Auditorium, National Institute of Polar Researc

STEREOSPECIFIC RADICAL POLYMERIZATION

Radical polymerization of N-tert-butoxycarbonylacrylamide (NBocAAm) in toluene at low temperatures in the presence of the fluorinated alcohols, 2,2,2-trifluoroethanol, 1,1,1,3,3,3-hexafluoro-2-propanol and nonafluoro-tert-butanol, afforded atactic, heterotactic and syndiotactic polymers, respectively. NMR analysis revealed that the fluorinated alcohols formed hydrogen bonding-assisted complexes with NBocAAm, with different structures. The difference in the structures of the complexes was responsible for the differences in the induced stereospecificities. Based on the structures of the complexes between NBocAAm and the fluorinated alcohols, mechanisms for the three kinds of stereospecific radical polymerizations are proposed

Metal-free isotactic-specific radical polymerization of N-alkylacrylamides with 3,5-dimethylpyridine N-oxide : The effect of the N-substituent and solvent on the isotactic specificity

Radical polymerization of N-methylacrylamide (NMAAm), N-n-propylacrylamide, N-isopropylacrylamide (NIPAAm) and N-benzylacrylamide was investigated in CHCl3, CH2Cl2 and CH3CN, in the presence of 3,5-dimethylpyridine N-oxide (35DMPNO) to examine the effects of the N-substituent and the solvent on the isotactic specificity induced by 35DMPNO. With addition of 35DMPNO to radical polymerization of N-alkylacrylamides in CHCl3, isotactic specificity was significantly induced in NIPAAm polymerization but only slightly induced in NMAAm polymerization. Furthermore, mixed solvents of CH3CN and halomethanes such as CHCl3 and CH2Cl2 enhanced the ability of 35DMPNO to induce isotactic specificity, and poly(NIPAAm) with 74% meso dyad was obtained

HETEROTACTIC POLY(N-ISOPROPYLACRYLAMIDE)

Radical polymerization of N-isopropylacrylamide (NIPAAm) in toluene at low temperatures, in the presence of fluorinated alcohols, produced heterotactic polymer comprising an alternating sequence of meso and racemo dyads. The heterotacticity reached 70% in triads when polymerization was carried out at –40°C using nonafluoro-tert-butanol as the added alcohol. NMR analysis revealed that formation of a 1:1 complex of NIPAAm and fluorinated alcohol through C=O•••H-O hydrogen bonding induces the heterotactic specificity. A mechanism for the heterotactic-specific polymerization is proposed. Examination of the phase transition behavior of aqueous solutions of heterotactic poly(NIPAAm) revealed that the hysteresis of the phase transition between the heating and cooling cycles depended on the average length of meso dyads in poly(NIPAAm)

A New Dissolution Effect of DMO on Human Pancreatic Stone : In vitro Study

In this study, we examined the dissolution effect of dimethadione (DMO) on pancreatic stones, when kept at 37°C in a DMO 0.05 M NaHC03 saline solution which was replaced once a week, were partially dissolved during a 12-week period. The decreasing stone weight ratios were 38% (1.0 g/1 DMO), 41% (0.5 g/1), 7% (0.1 g/1), and 2% (control). The DMO solution induced a concentration-dependent increase in the solubility of the pancreatic stones associated with a concentration-dependent fall in the solution pH. The eluted calcium concentration in the solution was measured after one week\u27s incubation, and then the decrease in stone weight in theory was calculated. The decrease in stone weight in practice, however, was more than the calculated weight in theory. To determine the reason for this discrepancy, we examined the solution microscopically for sediment and found amorphous substances indicating a concentration-dependent increase in the amount of sediment. These substances resembled artificially broken pancreatic stones and they were dissolved by bubbles following the addition of acetic acid. This phenomenon suggests that these substances and pancreatic stones consist of CaC03. Therefore, it appears DMO has the potency not only to dissolve CaCO3, but also to break pancreatic stones into small pieces

DU-PAN 2 Antigen in Sera of Patients with Liver Diseases

To evaluate the usefulness of serum DU-PAN 2 (an antigen defined by a monoclonal antibody raised against human pancreatic carcinoma cells), serum specimens from 370 cases of hepatobiliary and pancreatic diseases along with 31 normal controls were studied using an enzyme immunoassay. Elevated levels of serum DU-PAN 2 were detected in the serum of 28.3% of the cases with chronic hepatitis (15/53), 36.5% of those with liver cirrhosis (27/74), 48.4% of the hepatocellular carcinoma cases (61/126) and 50% of primary biliary cirrhosis (4/8). Significant differences were noted between patients with chronic inactive hepatitis (17 cases mean 201.4 U/ml) and chronic active hepatitis (36 cases; mean 394.5 U/ml) and, more distinctly, between patients with compensated liver cirrhosis (41 cases; mean 225.1 U/ml) and, those with decompensated liver cirrhosis (33 cases; mean 564.7 U/ml). The highest median levels were seen in patients with primary biliary cirrhosis (922.7 U/ml), and then in those with hepatocellular carcinoma (551.4 U/ml). Using an immunoperoxidase technique on formalin-fixed, deparaffinized liver sections, we showed that DU-PAN 2 reacted with bile-duct epithelium but never stained hepatoma cells. These results suggest that the determination of serum DU-PAN 2 can be useful in evaluating chronic liver diseases

Serum Levels of 7S Collagen in HCV-Ab Positive Chronic Liver Diseases

Serum 7S collagen was measured in 100 patients with Hepatitis C virus (HCV)-Ab positive chronic liver disease using RIA kit (7S-RIA : Japan DPC Corporation). The serum levels of 7S collagen were significantly higher in all types of liver diseases than those in 20 healthy controls (3.9±0.4 ng/ml). The 7S collagen level was 8.4±3.6 ng/ml (n = 30) in chronic hepatitis (CH), 14.4±8.1 ng/ml (n = 30) in liver cirrhosis (LC), 14.5 ±8.6 ng/ml (n=40) in hepatocellular carcinoma (HCC). In chronic hepatitis, chronic active hepatitis had a mean 7S collagen value of 9.8±3.8 ng/ml (n=19), while that of chronic inactive hepatitis was 6.1±1.8 ng/ml (n=11). In decompensated liver cirrhosis, the 7S collagen value was 17.6±9.2 ng/ml (n=17), whereas that of compensated LC was 10.2±3.1 ng/ml (n=13). In HCC, 7S collagen was examined according to the size of the tumor. In HCC with a diameter of less than 3 cm, the value was 11.0±4.2 ng/ml (n = 5). In 3 to 5 cm lesions, it was 12.5±5.8 ng/ml (n=16) and those more than 5 cm in diameter, it was 17.1 ±10.8 ng/ml (n=19). Although there were no significant differences according to size, there was a tendency for the level of 7S collagen to increase with the size of the tumor. The HCV-Ab titer and 7S collagen level showed no significant correlation. Measurement of serum 7S collagen may be useful for the evaluation of the degree of progression of LC and HCC

Preventative Effect of a Flavonoid, Enzymatically Modified Isoquercitrin on Ocular Symptoms of Japanese Cedar Pollinosis

ABSTRACTBackgroundFlavonoids are nutrients that exert anti-allergic effects. We investigated the preventative effect of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve the symptoms of Japanese cedar pollinosis.MethodsIn a parallel-group, double-blind placebo-controlled study design, 24 subjects with Japanese cedar pollinosis took 100 mg EMIQ or a placebo for 8 weeks, starting 4 weeks prior to the onset of pollen release. Subjective symptoms, ADL scores and the usage of drugs were recorded daily, and the QOL score was obtained every 4 weeks. Blood sampling was performed before and after the study to measure serum levels of IgE and flavonoids.ResultsDuring the entire study period, ocular symptom + medication score for the EMIQ group was significantly lower (p < 0.05) than that of the placebo group. When limited to the period, ocular symptom scores (p < 0.05, weeks 5–6), and ocular congestion scores (p < 0.05, weeks 5–6) for the EMIQ group was significantly lower than that for the placebo group while other scores for the EMIQ group, such as ocular itching scores (p = 0.09, weeks 4–5), lacrimation scores (p = 0.07, weeks 5–6), and ocular congestion scores (p = 0.06, weeks 45), all tended to be lower. However no significant differences were found in nasal symptoms between the two groups. Serum concentrations of IgE were not significantly downregulated but the serum concentrations of quercetin and its derivatives were elevated significantly by the intake of EMIQ.ConclusionsIntake of the quercetin glycoside EMIQ proved to be effective for the relief of ocular symptoms caused by Japanese cedar pollinosis