3 research outputs found
Anti-Müllerian hormone beyond an ovarian reserve marker: the relationship with the physiology and pathology in the life-long follicle development
Anti-Müllerian hormone (AMH), an indirect indicator of the number of remaining follicles, is clinically used as a test for ovarian reserve. Typically, a decline suggests a decrease in the number of remaining follicles in relation to ovarian toxicity caused by interventions, which may implicate fertility. In contrast, serum AMH levels are elevated in patients with polycystic ovary syndrome. AMH is produced primarily in the granulosa cells of the preantral and small antral follicles. Thus it varies in association with folliculogenesis and the establishment and shrinking of the follicle cohort. Ovarian activity during the female half-life, from the embryonic period to menopause, is based on folliculogenesis and maintenance of the follicle cohort, which is influenced by developmental processes, life events, and interventions. AMH trends over a woman’s lifetime are associated with in vivo follicular cohort transitions that cannot be observed directly
Sub-acute Toxicosis Caused by a Multiple Doses Tegafur/Uracil (UFT) for Suicide : A Case Report
Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative of
fluorouracil (5-FU) and uracil in a molar ratio of 1:4. UFT is effective as adjuvant chemotherapy for
breast cancer2, colorectal cancer3, non-small cell lung carcinoma4, head and neck cancer5 and other
tumors. We report a 41-year-old man who orally ingested a large dose of UFT (tegafur: 40000 mg/
uracil 9960mg)in an effort to commit suicide, and suffered from sub-acute toxicosis(main symptoms were
bone-marrow suppression, and hair loss) of UFT. His life was saved by empiric antibiotic chemical
treatment (meropenem, isapamicin, and micafungin), and granulocyte colony-stimulating factor (G
-CSF). In the case of toxicosis of UFT, strong antibacterial empiric chemotherapy and G-CSF are
necessary for rescue. If G-CSF is not work, biopsy of bone marrow woud be necessary, and the case of
no stem cells, bone marrow transfusion should be thought