Gauge-Invariant Cosmological Perturbations in Generalized Einstein Theories

Using the covariant approach and conformal transformations, we present a gauge-invariant formalism for cosmological perturbations in generalized Einstein theories (GETs), including the Brans-Dicke theory, theories with a non-minimally coupled scalar field and certain curvature-squared theories. We find an enhancement in the growth rate of density perturbations in the Brans-Dicke theory, and discuss attractive features of GETs in the structure formation process.Comment: LaTeX, 24 pages, 4 figures available on request, to appear in ApJ, August 1994, WU-AP/32/9

A Pilot Study of Barriers to Psychiatric Treatment among Japanese Healthcare Workers

Background: The medical service industry has the highest number of industry-classified workers’ compensation claims related to mental disorders. They are a group of people who particularly need mental health care.Aims: To investigate the barriers to seeking psychiatric treatment among healthcare workers. Methods: This cross-sectional survey was conducted for healthcare workers. We assessed the relationship between barriers to psychiatric treatment, stress perception, coping methods, and demographic variables.Results: There were 91 respondents in the final analysis (participants’ mean age was 34.73±11.41). Factor analysis identified three factors that affect resistance to seeking treatment (?=0.83): 1) anxiety toward psychiatric medicine, 2) resistance to psychiatric visits, and 3) lack of belief in the effectiveness of psychiatric treatment. Correlation analysis indicated that resistance to psychiatric treatment increased with age (r=0.21, p<0.05). In addition, women scored significantly higher than men concerning resistance toward psychiatric visits, and doctors scored lower than those in other occupations on this measure. Conclusion: These results indicated that a main component of resistance was related to resistance toward the word “psychiatric”. It may be useful to avoid using the word “psychiatric” with individuals belonging to groups with high resistance to psychiatric treatment when suggesting that they consult a psychiatrist

Total synthesis and biomimetic studies of nine-membered enediynes

The kedarcidin and C1027 chromophores are formidable targets of total synthesis. During our 20-year study of these nine-membered enediyne chromophores, several powerful, yet chemoselective methods have been developed: stereoselective epoxyalkyne formation, atropselective Pd/Cu-Sonogashira coupling, 2-deoxy-α-glycosylation, CeX3-mediated enediyne cyclisation, and SmI2-based reductive olefination. Besides their total syntheses, application of these methods to the biomimetic study of the putative enediyne-precursors of the cyanosporasides, sporolides, and fijiolides will be presented. In particular, we disclose biomimetic evidence of a p-benzyne diradical species reacting in either a radical mode (hydrogen abstraction) or ionic mode (chloride attack) at the same sterically exposed site, leading to either monochlorinated cyanosporaside A/F or cyanosporaside B–E, respectively. The ionic monochlorination of the cycloaromatized p-benzyne of the C1027 enediyne core to generate the fijiolide aglycon framework will also be presented

メンタルヘルス ノ キソ チシキ

玉手山学園メンタルヘルス研修会報

Modeling and emergence of flapping flight of butterfly based on experimental measurements

The objective of this paper is to clarify the principle of stabilization in flapping-of-wing flight of a butterfly, which is a rhythmic and cyclic motion. For this purpose, a dynamics model of a butterfly is derived by Lagrange’s method, where the butterfly is considered as a rigid multi-body system. For the aerodynamic forces, a panel method is applied. Validity of the mathematical models is shown by an agreement of the numerical result with the measured data. Then, periodic orbits of flapping-of-wing flights are searched in order to fly the butterfly models. Almost periodic orbits are obtained, but the model in the searched flapping-of-wing flight is unstable. This research, then, studies how the wake-induced flow and the flexibly torsional wing’s effect on the flight stability. Numerical simulations demonstrate that both the wake-induced flow and the flexible torsion reduces the flight instability. Because the obtained periodic flapping-of-wing flight is unstable, a feedback control system is designed, and a stable flight is realized

Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

非アルコール性脂肪性肝疾患を再現した腸・肝連結臓器チップの開発. 京都大学プレスリリース. 2023-04-07.Two-organ chip to answer fatty liver questions. 京都大学プレスリリース. 2023-04-07.Non-alcoholic fatty liver disease (NAFLD) afflicts a significant percentage of the population; however, no effective treatments have yet been established because of the unsuitability of in vitro assays and animal experimental models. Here, we present an integrated-gut-liver-on-a-chip (iGLC) platform as an in vitro human model of the gut-liver axis (GLA) by co-culturing human gut and liver cell lines interconnected via microfluidics in a closed circulation loop, for the initiation and progression of NAFLD by treatment with free fatty acids (FFAs) for 1 and 7 days, respectively. Co-cultured Caco-2 gut-mimicking cells and HepG2 hepatocyte-like cells demonstrate the protective effects from apoptosis against FFAs treatment, whereas mono-cultured cells exhibit induced apoptosis. Phenotype and gene expression analyses reveal that the FFAs-treated gut and liver cells accumulated intracellular lipid droplets and show an increase in gene expression associated with a cellular response to copper ions and endoplasmic reticulum stress. As an in vitro human GLA model, the iGLC platform may serve as an alternative to animal experiments for investigating the mechanisms of NAFLD