Is Sesamol Effective in Corneal Neovascularization?

OBJECTIVES: To evaluate the effects of topically and subconjunctivally administered sesamol on experimentally induced corneal neovascularization in rats. METHODS: Fifty-six right eyes of 56 Wistar Albino rats were chemically cauterized to induce corneal neovascularization in this experimental and comparative study. The subjects were divided into eight groups: topical sesamol (group 1), subconjunctival sesamol (group 2), topical bevacizumab (group 3), subconjunctival bevacizumab (group 4), topical bevacizumab+ sesamol (group 5), subconjunctival bevacizumab+ sesamol (group 6), topical Tween 80 (group 7), and control (group 8). The amount of subconjunctivally injected sesamol and bevacizumab was 1.25 mg each. Topical groups were administered 10 mg/mL drops twice daily. The control group was left untreated. To evaluate the degree of corneal neovascularization, digital photographs and corneal sections stained with hematoxylin-eosin and CD31 were used. RESULTS: When photographs of neovascularization areas were examined, all treatment groups showed statistically significant differences when compared with the control group (P<0.001). Topical sesamol was found to be more effective when compared with subconjunctival sesamol (P=0.003). Topical sesamol+ bevacizumab was found to be more effective when compared with topical bevacizumab (P=0.018). The numbers of new corneal vessels were as follows: 12.28±6.29 in group 1, 36.85±12.8 in group 2, 18.85±7.71 in group 3, 16.85±8.70 in group 4, 19.57±8.56 in group 5, 22.57±7.43 in group 6, 45.00±11.29 in group 7, and 51.16±5.91 in group 8 (P<0.001). CONCLUSIONS: The outcomes of this study suggest antiangiogenic effects of sesamol. The use of topical sesamol monotherapy or sesamol combined with bevacizumab may be options for the prevention of corneal neovascularization

Is Sesamol Effective in Corneal Neovascularization?

Objectives: To evaluate the effects of topically and subconjunctivally administered sesamol on experimentally induced corneal neovascularization in rats.Methods: Fifty-six right eyes of 56 Wistar Albino rats were chemically cauterized to induce corneal neovascularization in this experimental and comparative study. The subjects were divided into eight groups: topical sesamol (group 1), subconjunctival sesamol (group 2), topical bevacizumab (group 3), subconjunctival bevacizumab (group 4), topical bevacizumab+ sesamol (group 5), subconjunctival bevacizumab+ sesamol (group 6), topical Tween 80 (group 7), and control (group 8). The amount of subconjunctivally injected sesamol and bevacizumab was 1.25 mg each. Topical groups were administered 10 mg/mL drops twice daily. The control group was left untreated. To evaluate the degree of corneal neovascularization, digital photographs and corneal sections stained with hematoxylin-eosin and CD31 were used.Results: When photographs of neovascularization areas were examined, all treatment groups showed statistically significant differences when compared with the control group (P<0.001). Topical sesamol was found to be more effective when compared with subconjunctival sesamol (P=0.003). Topical sesamol+ bevacizumab was found to be more effective when compared with topical bevacizumab (P=0.018). The numbers of new corneal vessels were as follows: 12.28 +/- 6.29 in group 1, 36.85 +/- 12.8 in group 2, 18.85 +/- 7.71 in group 3, 16.85 +/- 8.70 in group 4, 19.57 +/- 8.56 in group 5, 22.57 +/- 7.43 in group 6, 45.00 +/- 11.29 in group 7, and 51.16 +/- 5.91 in group 8 (P<0.001).Conclusions: The outcomes of this study suggest antiangiogenic effects of sesamol. The use of topical sesamol monotherapy or sesamol combined with bevacizumab may be options for the prevention of corneal neovascularization

Does fundus fluorescein angiography procedure affect ocular pulse amplitude?

Purpose. This study examines the effects of fundus fluorescein angiography (FFA) procedure on ocular pulse amplitude (OPA) and intraocular pressure (IOP). Materials and Methods. Sixty eyes of 30 nonproliferative diabetic retinopathy patients (15 males, 15 females) were included in this cross-sectional case series. IOP and OPA were measured with the Pascal dynamic contour tonometer before and after 5 minutes of intravenous fluorescein dye injection. Results. Pre-FFA mean OPA value was 3.05 ± 1.36 mmHg and post-FFA mean OPA value was 2.93 ± 1.28 mmHg (P = 0.071). Pre-FFA mean IOP value was 17.97 ± 1.99 mmHg and post-FFA mean IOP value was 17.81 ± 2.22 mmHg (P = 0.407). Conclusion. Although both mean OPA and IOP values were decreased after FFA procedure, the difference was not statistically significant. This clinical trial is registered with Australian New Zealand Clinical Trials Registry number ACTRN12613000433707

Chorio-retinal thickness measurements in patients with acromegaly

Purpose To compare choroidal, foveal, and peripapillary retinal thickness between patients with acromegaly and healthy adults.Methods This prospective, cross-sectional, and comparative study included 30 patients with acromegaly (study group) and 30 healthy subjects (control group). The subfoveal choroidal thickness (SFCT), foveal thickness, and peripapillary retinal nerve fibre layer thickness were measured with spectral domain optical coherence tomography.Results The mean SFCT in the study group and in the control eyes was 374.4 +/- 98.1 and 308.6 +/- 77.3 mu m, respectively (P<0.001). The mean thinnest foveal thickness value was 233.2 +/- 22.4 mu m in the acromegaly group and 222.8 +/- 13.9 mu m in the control group (P = 0.003). The mean peripapillary retinal nerve fibre layer thickness did not differ significantly between the groups (P = 0.34).Conclusion The SFCT and foveal thickness were significantly higher in patients with acromegaly, whereas peripapillary retinal nerve fibre layer thickness was similar between the groups

Relationship Between Subfoveal Choroidal Thickness, Ocular Pulse Amplitude, and Intraocular Pressure in Healthy Subjects.

PURPOSE: To investigate the correlation between subfoveal choroidal thickness (SFCT), ocular pulse amplitude (OPA), and intraocular pressure (IOP) in healthy individuals. METHODS: In total, 106 eyes of 106 healthy adult participants were included in this cross-sectional study. Spectral-domain optical coherence tomography was used to measure the SFCT. OPA and IOP were measured with the Pascal dynamic contour tonometer. The Pearson correlation test was performed to examine the relationship between SFCT, OPA, and IOP. RESULTS: When age, sex, and body mass index (BMI) were controlled separately, a weak correlation occurred between SFCT and OPA (age controlled, r=0.20; sex controlled, r=0.19; BMI controlled, r=0.13). SFCT and OPA were fairly correlated in older age (r=0.33, P=0.02) and low BMI (r=0.33, P=0.02). SFCT and IOP were not correlated statistically significantly (r=0.05, P=0.59). CONCLUSION: There is a weak correlation between SFCT and OPA in healthy individuals when age is controlled. The association becomes stronger in participants with low BMI. There is no relation between SFCT and IOP