ANALYSIS OF ROLE OF MAGNESIUM SULPHATE IN ECLAMPSIA AND PRE-ECLAMPSIA

Introduction: Magnesium sulfate (MgSC4) is the agent most commonly used for treatment of eclampsia and prophylaxis of eclampsia in patients with severe pre-eclampsia. Aims and objectives: The basic aim of the study is to analyze the role of magnesium sulphate in eclampsia and pre-eclampsia women in Pakistan. Material and methods: This descriptive study was conducted in King Edward Medical University, Lahore during March 2018 to November 2018. This study was done with the permission of ethical committee of hospital. The data was collected from 100 female patients. Data was collected through a systematically designed questionnaire. The survey included facility characteristics, MgSO4 availability and potential barriers to its access, availability and distribution of clinical protocols for MgSO4 use, MgSO4 dosing regimens for the treatment of pre‐eclampsia and eclampsia, institutional capacity to manage MgSO4 toxicity, and preferences for different options of simplified MgSO4 regimens. Results: The data were collected from 100 female patients. Respondents reported that 24.3% of all facilities used MgSO4 for treatment of mild pre‐eclampsia (35.1% in Latin America, 22.7% in Asia and 18.6% in Africa). Over 90% of health facilities in all three regions used MgSO4 for treatment of severe pre‐eclampsia and eclampsia. With respect to the diagnosis and management of MgSO4 toxicity, 27.8% of all facilities reported having the capacity to routinely measure serum magnesium concentration. Conclusion: It is concluded that here was no association between adverse outcomes and maternal serum magnesium concentrations and no maternal mortality occurred. Magnesium sulphate was effective in preventing recurrence of eclamptic fits and safe for both mother and fetus

The Etiological Spectrum OF Short Stature among Children Attending Endocrine Clinic at Tertiary Care Hospital

Background: One of the most frequent reasons for referral to pediatric endocrinology units is short stature. Children’s short height has a complicated etiology that includes genetics, race, gender, nutrition, and several endocrine hormones. Objective: To determine the etiological spectrum of short stature among children presenting to endocrinology outpatient clinics in a tertiary care hospital. Methods: This descriptive cross-sectional study was performed in the outpatient clinic of the Endocrinology Department at the National Institute of Child Health Hospital from September to December 2022. Short stature was defined as height for age <-2 standard deviations for the corresponding age and gender according to World Health Organization growth charts. 263 children were enrolled in the study. Detailed history and panel investigation for short stature were mediated for each child. Results: A total of 263 patients were enrolled in the study having a median age of 8 (IQR=6-9) years and the majority were females (53.2%). The median SD of height and current weight was -3.48 (IQR= -4.3 - -2.83) and -2.8 (IQR= -3.59 - -2.17) respectively. The most frequently seen classification of short stature was the normal variant (68.1%) followed by endocrine disorders (19.8%), dysmorphic syndrome (9.9%), and chronic disease (2.3%). The most common cause of short stature was familial short stature (47.9%) followed by growth hormone deficiency (18.3%), constitutional short stature (9.1%), Turner syndrome (9.1%), both familial and constitutional SS (8%), idiopathic short stature (3%), celiac disease (2.3%), Cushing syndrome (n=2, 0.8%), panhypopituitarism (0.8%) and Seckel syndrome (0.8%). Conclusion: This study analyzed that the majority of short stature are normal variants. However, findings of endocrine disorders, dysmorphic disorders, and chronic disease suggest timely screening and detection of short stature to avoid serious consequences of silent underlying diseases

Soil Mapping Using Electromagnetic Induction to Assess the Suitability of Land for Growing Leptospermum nitens in Western Australia

Leptospermum sp. with dihydroxyacetone in their nectar are a source of high-value medicinal honey production and can provide income from agriculturally marginal lands. The current study was from two newly planted Leptospermum nitens sites, one with duplex soil and the other in deep sandy soil, in the low rainfall areas of the south-west of Western Australia, with the aim of identifying key soil parameters influencing the plantation’s survival and growth. Electromagnetic induction (EMI) at different depths was used to investigate the possible impact of soil variability on the Leptospermum nitens plantations. Two EMI surveys were conducted at each site, at different times of the year, to account for soil moisture variability (relatively dry and wet conditions). A least-square inversion algorithm was used to determine true electrical conductivities at three different soil depths (0–0.5, 0.5–0.8, and 0.8–1.6 m) to produce quasi-3D maps of soil inverted electrical conductivity. Corresponding soil samples from each depth were used for the physico-chemical analysis of soil parameters and to develop laboratory-based electrical resistivity to soil volumetric moisture calibrations with R2 values between 0.95 and 0.99. Shrub survival and growth (canopy diameter) were estimated using unmanned aerial vehicle (UAV) images and machine learning. Comparing EMI soil mapping with UAV imagery results showed significantly greater shrub survival and growth (p &lt; 0.001) in areas with higher ECa ranges of 12–24 mS m−1 at the variable textured site and 6–9 mS m−1 at the uniformly sandy site. Overall, the variable textured site, with an 82% survival rate, had a significantly higher shrub count and larger plants than the uniformly sandy site, with a 75% survival rate. A principal component analysis (PCA) identified inverted EC to be strongly correlated with soil moisture &gt; pH &gt; soil texture. Such soil mapping may be a robust and effective method for risk assessment of new shrub plantations

Analysis of Homotopy Perturbation Method for Solving Fractional Order Differential Equations

The analysis of Homotopy Perturbation Method (HPM) for the solution of fractional partial differential equations (FPDEs) is presented. A unified convergence theorem is given. In order to validate the theory, the solution of fractional-order Burger-Poisson (FBP) equation is obtained. Furthermore, this work presents the method to find the solution of FPDEs, while the same partial differential equation (PDE) with ordinary derivative i.e., for α = 1 , is not defined in the given domain. Moreover, HPM is applied to a complicated obstacle boundary value problem (BVP) of fractional order

QUALITY CONTROL TESTING OF VARIOUS SAMPLES OF PEPPERMINT OIL COLLECTED FROM LOCAL MARKET OF KARACHI, PAKISTAN

Menthol is the most commonly used substance in many cosmetics and pharmaceutical products either as an active ingredient or in the form of excipient. In the present study, different samples of commercially available peppermint oil were subjected to standardization by determination of physicochemical characteristics, acid value, and resinified oil content. Thin layer chromatography (TLC) has been used to confirm the presence of menthol. The result showed that the quality control test performed for the evaluation of the physicochemical parameters of peppermint oil can be considered useful in its standardization. The results of acid value and the resinified oil tests, carried out on the raw material, have found to be within the standard limits. The results indicated specified number of free fatty acids and absence of greasy impurities. The data obtained from the study would be useful in the authentication of the commercial peppermint oil samples. In TLC studies, the Rf value of the active constituent has been determined by comparison with its standard spot. This technique may be used as a tool for the correct identification of the active constituent which could help in the standardization of the peppermint oil samples

Effectiveness of continuous passive motion protocol as an adjunct to standard physiotherapy protocol for post-operative rehabilitation in Total Knee Arthroplasty (TKA) cases

Osteoarthritis (OA) of the knee is a relatively prevalent disorder, and prevalence rises with age. Total knee replacement surgery (TKA) is a frequent operation that has significantly improved the quality of life for millions of people with symptomatic knee OA. TKA postoperative care has been discussed regarding the utility of CPM; it has been shown to speed up the recovery of full range of motion, shorten hospital stays, lessen discomfort, speed up wound healing, and lower the risk of DVT. The current study was conducted to compare Effectiveness of CPM protocol as an adjunct to Standard Physiotherapy protocol in Post-operative Rehabilitation of TKA cases. From July to December 2021, three affiliated hospitals hosted the randomised controlled study, which included patients who had complete knee arthroplasty surgery. After surgery, patients were randomly allocated to one of two groups: From the first surgical day till discharge, Group A got twice daily PT and continuous passive motion (CPM), while Group B only received the usual physiotherapy programme from the first postoperative day. Evaluation of the results took place the day after discharge. The participants in the 2 groups' baseline outcome measurement characteristics were comparable.&nbsp

Ambulance use in Pakistan: An analysis of surveillance data from emergency departments in Pakistan

© 2015 Zia et al. Background: The utilization of ambulances in low- and middle-income countries is limited. The aim of this study was to ascertain frequency of ambulance use and characteristics of patients brought into emergency departments (EDs) through ambulance and non-ambulance modes of transportation. Methods: The Pakistan National Emergency Departments Surveillance (Pak-NEDS) was a pilot active surveillance conducted in seven major tertiary-care EDs in six main cities of Pakistan between November 2010 and March 2011. Univariate and multivariate logistic regression was performed to investigate the factors associated with ambulance use. Results: Out of 274,436 patients enrolled in Pak-NEDS, the mode of arrival to the ED was documented for 94. 9% (n = 260,378) patients, of which 4.1% (n = 10,546) came to EDs via ambulances. The mean age of patients in the ambulance group was significantly higher compared to the mean age of the non-ambulance group (38 ± 18.4 years versus 32.8 ± 14.9 years, p-value \u3c 0.001). The most common presenting complaint in the ambulance group was head injury (12%) while among non-ambulance users it was fever (12%). Patients of all age groups were less likely to use an ambulance compared to those \u3e45 years of age (p-value \u3c 0.001) adjusted for gender, cities, hospital type, presenting complaint group and disposition. The adjusted odds ratio of utilizing ambulances for those with injuries was 3.5 times higher than those with non-injury complaints (p-value \u3c 0.001). Patients brought to the ED by ambulance were 7.2 times more likely to die in the ED than non-ambulance patients after adjustment for other variables in the model. Conclusion: Utilization of ambulances is very low in Pakistan. Ambulance use was found to be more among the elderly and those presenting with injuries. Patients presenting via ambulances were more likely to die in the ED