Video-based assessment of intraoperative surgical skill

Purpose: The objective of this investigation is to provide a comprehensive analysis of state-of-the-art methods for video-based assessment of surgical skill in the operating room. Methods: Using a data set of 99 videos of capsulorhexis, a critical step in cataract surgery, we evaluate feature based methods previously developed for surgical skill assessment mostly under benchtop settings. In addition, we present and validate two deep learning methods that directly assess skill using RGB videos. In the first method, we predict instrument tips as keypoints, and learn surgical skill using temporal convolutional neural networks. In the second method, we propose a novel architecture for surgical skill assessment that includes a frame-wise encoder (2D convolutional neural network) followed by a temporal model (recurrent neural network), both of which are augmented by visual attention mechanisms. We report the area under the receiver operating characteristic curve, sensitivity, specificity, and predictive values with each method through 5-fold cross-validation. Results: For the task of binary skill classification (expert vs. novice), deep neural network based methods exhibit higher AUC than the classical spatiotemporal interest point based methods. The neural network approach using attention mechanisms also showed high sensitivity and specificity. Conclusion: Deep learning methods are necessary for video-based assessment of surgical skill in the operating room. Our findings of internal validity of a network using attention mechanisms to assess skill directly using RGB videos should be evaluated for external validity in other data sets

OpenKBP-Opt: an international and reproducible evaluation of 76 knowledge-based planning pipelines

Objective: To establish an open framework for developing plan optimization models for knowledge-based planning (KBP). Approach: Our framework includes radiotherapy treatment data (i.e. reference plans) for 100 patients with head-and-neck cancer who were treated with intensity-modulated radiotherapy. That data also includes high-quality dose predictions from 19 KBP models that were developed by different research groups using out-of-sample data during the OpenKBP Grand Challenge. The dose predictions were input to four fluence-based dose mimicking models to form 76 unique KBP pipelines that generated 7600 plans (76 pipelines × 100 patients). The predictions and KBP-generated plans were compared to the reference plans via: the dose score, which is the average mean absolute voxel-by-voxel difference in dose; the deviation in dose-volume histogram (DVH) points; and the frequency of clinical planning criteria satisfaction. We also performed a theoretical investigation to justify our dose mimicking models. Main results: The range in rank order correlation of the dose score between predictions and their KBP pipelines was 0.50-0.62, which indicates that the quality of the predictions was generally positively correlated with the quality of the plans. Additionally, compared to the input predictions, the KBP-generated plans performed significantly better (P\u3c 0.05; one-sided Wilcoxon test) on 18 of 23 DVH points. Similarly, each optimization model generated plans that satisfied a higher percentage of criteria than the reference plans, which satisfied 3.5% more criteria than the set of all dose predictions. Lastly, our theoretical investigation demonstrated that the dose mimicking models generated plans that are also optimal for an inverse planning model. Significance: This was the largest international effort to date for evaluating the combination of KBP prediction and optimization models. We found that the best performing models significantly outperformed the reference dose and dose predictions. In the interest of reproducibility, our data and code is freely available