Cardiac Magnetic Resonance Imaging of COVID-19-Associated Cardiac Sequelae: A Systematic Review

Background: Many COVID-19 survivors experience persistent COVID-19 related cardiac abnormalities weeks to months after recovery from acute SARS-CoV-2 infection. Non-invasive cardiac magnetic resonance (CMR) imaging is an important tool of choice for clinical diagnosis of cardiac dysfunctions. In this systematic review, we analyzed the CMR findings and biomarkers of COVID-19 related cardiac sequela after SARS-CoV-2 infection. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), we conducted a systematic review of studies that assessed COVID-19 related cardiac abnormalities using cardiovascular magnetic resonance imaging. A total of 21 cross-sectional, case-control, and cohort studies were included in the analyses. Results: Ten studies reported CMR results 3 months after SARS-CoV-2 infection. Abnormal T1, abnormal T2, elevated extracellular volume, late gadolinium enhancement and myocarditis was reported less frequently in the >3-month studies. Eight studies reported an association between biomarkers and CMR findings. Elevated troponin was associated with CMR pathology in 5/6 studies, C-reactive protein in 3/5 studies, N-terminal pro-brain natriuretic peptide in 1/2 studies, and lactate dehydrogenase and D-dimer in a single study. The rate of myocarditis via CMR was 18% (154/868) across all studies. Most SARS-CoV-2 associated CMR abnormalities resolved over time. Conclusions: There were CMR abnormalities associated with SARS-CoV-2 infection and most abnormalities resolved over time. A panel of cardiac injury and inflammatory biomarkers could be useful in identifying patients who are likely to present with abnormal CMR pathology after COVID-19. Multiple mechanisms are likely responsible for COVID-19 induced cardiac abnormalities

The New Horizons Mission to Pluto and Flyby of Jupiter

New Horizons (NH) is NASA's mission to provide the first in situ reconnaissance of Pluto and its moons Charon, Nix, and Hydra. The NH spacecraft will reach Pluto in July 2015 and will then, if approved for an extended mission phase, continue on to a flyby encounter with one or more Kuiper belt objects (KBOs). NH was launched on 19 January 2006 and received a gravity assist during a flyby encounter with Jupiter (with closest approach at -32 RJ on 28 February 2007) that reduced its flight time to Pluto by 3 years. During the Jupiter flyby, NH collected a trove of multi-wavelength imaging and fields-and-particles measurements. Among the many science results at Jupiter were a detection of planet-wide mesoscale waves, eruptions of atmospheric ammonia clouds, unprecedented views of Io's volcanic plumes and Jupiter's tenuous ring system, a first close-up of the Little Red Spot (LRS), first sightings of polar lightning, and a trip down the tail of the magnetosphere. In 2015, NH will conduct a seven-month investigation of the Pluto system culminating in a closest approach some 12,500 km from Pluto's surface. Planning is presently underway for the Pluto encounter with special emphasis on longidentified science goals of studying the terrain, geology, and composition of the surfaces of Pluto and Charon, examining the composition and structure of Pluto's atmosphere, searching for an atmosphere on Charon, and characterizing Pluto's ionosphere and solar wind interaction. Detailed inspections will also be performed of the newly discovered satellites Nix and Hydra. Additionally, NH will characterize energetic particles in Pluto's environment, refine the bulk properties of Pluto and Charon, and search for additional satellites and rings