Seroprevalence of Respiratory Syncytial Virus among Rural Population: Insights into Infection Rates and Immune Status: Pilot Study

Respiratory Syncytial Virus (RSV) is a significant cause of respiratory tract infections, particularly affecting infants, young children, and immunocompromised individuals, with a substantial global burden of morbidity and mortality. This study aimed to assess the seroprevalence of RSV among a rural population in Karad Taluka, India, an area where RSV data is scarce due to its predominantly urban focus. Ethical approval was obtained, and written informed consent was collected from participants' parents or legal guardians Blood samples were collected from individuals aged 16 months to 5 years residing in rural areas, and IgM RSV-specific antibodies were detected to identify recent infections using SERION enzyme-linked immunosorbent assay (ELISA). Additionally, demographic information and clinical history were collected through a structured questionnaire. The data were entered into an electronic database, and seroprevalence was calculated based on the proportion of individuals with positive serological results. The study revealed that by the age of 3 years, 81.0% of children exhibited IgM seropositivity to RSV, with a cumulative seroprevalence of 72% in the entire study population. The seroprevalence varied with age, demonstrating an ongoing RSV activity within the community, as evidenced by the high IgM positivity. However, as children grew older, a decline in IgM positivity was observed, possibly due to protective antibodies developed from previous exposures or a longer time elapsed between RSV exposure and sample collection in older children. These findings underscore the vulnerability of young infants to RSV and the need for early protection in India. It highlights the importance of considering timing and age-appropriate administration of RSV vaccines in vaccination strategies, as well as the potential limitations of maternal immunization in protecting preterm infants. Understanding RSV seroprevalence in rural areas is crucial for guiding public health interventions and resource allocation to mitigate the impact of this virus on vulnerable populations, particularly young children who are at the highest risk

Disease Prevalence Due to Human Respiratory Syncytial Virus (HRSV) and Molecular Nature of G Gene in Different Geographical Region of India: 2005-2022

Human respiratory syncytial virus (hRSV) is the leading pediatric respiratory pathogen with high morbidity in the first year of life. The morbidity is particularly high in developing countries. it is the most common cause of infant hospitalization and causes a high burden of disease in the elderly. India is a country with vast geographical differences their unique climatic conditions. So, the prevalence of human RSV in different geographical regions is partially understood for a long time.  This review was performed by using a different search engine like Google schooler, PubMed, etc. Significant prevalence and specific RSV virus strain circulation were major keywords used for the search in the Indian pediatric population. Annual incidence rates of RSV–associated hospitalization per 1000 children were highest among infants aged 0–5 months, followed by ages 6–23 months, and lowest among children 24–59 months. hRSV was a substantial cause of hospitalization among children aged < 24 months especially those aged <6 months. Prevalence varies from 2.1% to 44% in different geographical regions. hRSV has a more broadly distributed peak timing. numerous studies of the correlation between climatic factors and hRSV incidence across latitudes found variable and inconsistent correlations between hRSV incidence & temperature, and relative humidity in different parts of the tropical region.However, genotypes ON1, NA1, GA5, and GA2 in the hRSV-A group and group hRSV-B BA, BA9, and BA12 were predominantly circulated in India