Online drug scenes and harm reduction from below as phronesis

This article presents a theoretical critique of notion of harm reduction on the basis of an empirical investigation of a variety of online manifestations of drug culture. Taking a multi-case study approach to drug use related forums, blogs and ‘story sites’ focused on NPS/’legal high’ use and non-medicinal prescription drug use, our analysis of data leads us to describe the culture of ‘harm reduction from below’ it reveals in terms the Aristotelian concept of phronesis. We argue that peer-to-peer co-creation of knowledge, sharing and support constitutes an emergent and constantly evolving form of ‘practical wisdom’ with respect to drugs. Drawing on Flyvbjerg’s (2001, 2007) accounts of phronetic social science as a practice, which proposes a permeable boundary between theoretical and practical inquiry, and Stenger’s (2005) account of the ‘collective voice from below’ as always embedded within an ‘ecology of practices’, we offer an interpretation of the online dimension of drug taking in terms of drug users’ shared aim of ‘doing drugs well’. The investigation of online life in terms of the multiple contexts of drug-related communicative exchange thus allows us to identify harm reduction from below as an ethical practice inherent to a variety of online drug scenes themselves

Whole Earth Telescope Observations of the Helium Interacting Binary PG 1346+082 (CR Bootis)

We present our analysis of 240 hr of white-light, high-speed photometry of the dwarf nova-like helium variable PG 1346+082 (CR Boo). We identify two frequencies in the low-state power spectrum, at 679.670 ± 0.004 μHz and 669.887 ± 0.008 μHz. The 679.670 μHz variation is coherent over at least a 2 week time span, the first demonstration of a phase-coherent photometric variation in any dwarf nova-like interacting binary white dwarf system. The high-state power spectrum contains a complex fundamental with a frequency similar, but not identical, to the low-state spectrum, and a series of harmonics not detected in low state. We also uncover an unexpected dependence of the high-frequency power\u27s amplitude and frequency structure on overall system magnitude. We discuss these findings in light of the general AM CVn system model, particularly the implications of the high-order harmonics on future studies of disk structure, mass transfer, and disk viscosity

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Sea ice near the McMurdo Science Station in Antarctica.

The operation of remote science exploration vehicles benefits greatly from the application of advanced telepresence and virtual reality operator interfaces. Telepresence, or the projection of the human sensory apparatus into a remote location, can provide scientists with a much greater intuitive understanding of the environment in which they are working than simple camera-display systems. Likewise virtual reality, or the use of highly interactive three-dimensional computer graphics, can both enhance an operator’s situational awareness of an environment and also compensate (to some degree) for low bandwidth and/or long time delays in the communications channel between the operator and the vehicle. These advanced operator interfaces are important for terrestrial science and exploration applications, and are critical for missions involving the exploration of other planetary surfaces, such as on Mars. The undersea environment provides an excellent terrestrial analog to science exploration and operations on another planetary surface