Self-assembled monolayers of bisphosphonates: Influence of side chain steric hindrance

Bisphosphonates form self-assembled monolayers (SAMs) spontaneously on stainless steel, silicon, and titanium oxidized surfaces. We used contact angle measurements, atomic force microscopy, and X-ray reflectivity analysis to study the formation of SAMs on a model surface of ultraflat titanium (rms=0.2 nm). The results were extended to standard materials (mechanically polished titanium, stainless steel, and silicon) and showed that water-soluble bisphosphonic perfluoropolyether can easily form SAMs, with 100% surface coverage and a layer thickness of less than 3 nm. Hydrophobic (water contact angle >110° on stainless steel or titanium) and lipophobic (methylene iodide contact angle >105° on titanium) properties are discussed in terms of industrial applications

Microencapsulation of Proteins within Polymeric and Inorganic Particles using Supercritical CO2 Media

International audienc

Microencapsulation of proteins within CaCO3 microspheres using supercritical CO2 media

International audienc

Encapsulation de proteins thérapeutiques dans des microspheres de CaCO3 élaborées en milieu CO2 supercritique

National audienc