Additional file 1: Table S1. of Introduction of p16INK4a as a surrogate biomarker for HPV in women with invasive cervical cancer in Sudan

Frequency of p16INK4a/Ki-67 immunostaining according to diagnosis and HPV infection in the 63 cervical tumor cases. (DOCX 51 kb

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits

DNA methylation and blood circulating proteins have been associated with many complex disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we report an epigenome-wide association study of 1123 proteins from 944 participants of the KORA population study and replication in a multi-ethnic cohort of 344 individuals. We identify 98 CpG-protein associations (pQTMs) at a stringent Bonferroni level of significance. Overlapping associations with transcriptomics, metabolomics, and clinical endpoints suggest implication of processes related to chronic low-grade inflammation, including a network involving methylation of NLRC5, a regulator of the inflammasome, and associated pQTMs implicating key proteins of the immune system, such as CD48, CD163, CXCL10, CXCL11, LAG3, FCGR3B, and B2M. Our study links DNA methylation to disease endpoints via intermediate proteomics phenotypes and identifies correlative networks that may eventually be targeted in a personalized approach of chronic low-grade inflammation.Other Information Published in: Nature Communications License: https://creativecommons.org/licenses/by/4.0See article on publisher's website: http://dx.doi.org/10.1038/s41467-019-13831-w</p