Gay and bisexual men’s perceptions of the donation and use of human biological samples for research: a qualitative study

Human biological samples (biosamples) are increasingly important in diagnosing, treating and measuring the prevalence of illnesses. For the gay and bisexual population, biosample research is particularly important for measuring the prevalence of human immunodeficiency virus (HIV). By determining people’s understandings of, and attitudes towards, the donation and use of biosamples, researchers can design studies to maximise acceptability and participation. In this study we examine gay and bisexual men’s attitudes towards donating biosamples for HIV research. Semi-structured telephone interviews were conducted with 46 gay and bisexual men aged between 18 and 63 recruited in commercial gay scene venues in two Scottish cities. Interview transcripts were analysed thematically using the framework approach. Most men interviewed seemed to have given little prior consideration to the issues. Participants were largely supportive of donating tissue for medical research purposes, and often favourable towards samples being stored, reused and shared. Support was often conditional, with common concerns related to: informed consent; the protection of anonymity and confidentiality; the right to withdraw from research; and ownership of samples. Many participants were in favour of the storage and reuse of samples, but expressed concerns related to data security and potential misuse of samples, particularly by commercial organisations. The sensitivity of tissue collection varied between tissue types and collection contexts. Blood, urine, semen and bowel tissue were commonly identified as sensitive, and donating saliva and as unlikely to cause discomfort. To our knowledge, this is the first in-depth study of gay and bisexual men’s attitudes towards donating biosamples for HIV research. While most men in this study were supportive of donating tissue for research, some clear areas of concern were identified. We suggest that these minority concerns should be accounted for to develop inclusive, evidence-informed research protocols that balance collective benefits with individual concerns

Sustainable Cities: Canadian Reality or Urban Myth?

Although it is now over two decades since the Brundtland Commission report (1987) put sustainable development on the political map, concern continues in Canada that the federal government is failing to adequately implement its own commitments to tackling the ecological challenges posed by rapid urban expansion. Our analysis identifies a number of road blocks, missed opportunities and mistakes that have limited progress and many of these are traced back to the failure of national government to empower local municipal governments, as advocated by Brundtland and subsequent international initiatives, in particular ‘Agenda 21’ which we revisit in some detail as a basis for analysis. As well as reviewing the federal government’s role in Canada, the paper explores the potential for more sustainable urban growth in the context of broader reforms

Fixation-related potentials during mobile map assisted navigation in the real world: The effect of landmark visualization style

An often-proposed enhancement for mobile maps to aid assisted navigation is the presentation of landmark information, yet understanding of the manner in which they should be displayed is limited. In this study, we investigated whether the visualization of landmarks as 3D map symbols with either an abstract or realistic style influenced the subsequent processing of those landmarks during route navigation. We utilized a real-world mobile electroencephalography approach to this question by combining several tools developed to overcome the challenges typically encountered in real-world neuroscience research. We coregistered eye-movement and EEG recordings from 45 participants as they navigated through a real-world environment using a mobile map. Analyses of fixation event-related potentials revealed that the amplitude of the parietal P200 component was enhanced when participants fixated landmarks in the real world that were visualized on the mobile map in a realistic style, and that frontal P200 latencies were prolonged for landmarks depicted in either a realistic or abstract style compared with features of the environment that were not presented on the map, but only for the male participants. In contrast, we did not observe any significant effects of landmark visualization style on visual P1-N1 peaks or the parietal late positive component. Overall, the findings indicate that the cognitive matching process between landmarks seen in the environment and those previously seen on a map is facilitated by more realistic map display, while low-level perceptual processing of landmarks and recall of associated information are unaffected by map visualization style

Landmark Sequence Learning from Real-World Route Navigation and the Impact of Navigation Aid Visualisation Style

Primacy and recency features of serial memory are a hallmark of typical memory functions that have been observed for a wide array of tasks. Recently, the ubiquity of this serial position effect has been supported for objects learned during navigation, with canonical serial position functions observed for sequence memory of landmarks that were encountered along a route during a highly controlled virtual navigation task. In the present study, we extended those findings to a real-world navigation task in which participants actively walked a route through a city whilst using a navigation aid featuring either realistic or abstract landmark visualisation styles. Analyses of serial position functions (i.e., absolute sequence knowledge) and sequence lags (i.e., relative sequence knowledge) yielded similar profiles to those observed in a lab based virtual navigation task from previous work and non-spatial list learning studies. There were strong primacy effects for serial position memory in both conditions; recency effects only in the realistic visualisation condition; a non-uniform distribution of item-lags peaking at lag +1; and an overall bias towards positive lags for both visualisation conditions. The findings demonstrate that benchmark serial position memory effects can be observed in uncontrolled, real-world behaviour. In a navigation context, the results support the notion that general memory mechanisms are involved in spatial learning, and that landmark sequence knowledge is a feature of spatial knowledge which is affected by navigation aids

Limiting the reliance on navigation assistance with navigation instructions containing emotionally salient narratives for confident wayfinding

We live in a world that is increasingly dependent on technology, including for orientation in both familiar and unfamiliar space, which contributes to a long-term erosion of innate spatial navigation skills. In this study, we examined whether modified navigation instructions can make pedestrians less reliant on navigation aids to solve wayfinding tasks. In contrast to standard instructions, the modified instructions make decision-relevant landmarks at intersections emotionally salient and connected through narrative, and thus more memorable. The results of our online VR study with seventy adults revealed that, after navigating an unfamiliar route using modified navigation instructions, people made significantly fewer references to the navigation aid without compromising the accuracy of navigation compared to standard instructions. Narrative-based navigation instructions improved memory for the order in which relevant features in the environment were encountered along the traversed route, but not landmark recognition memory or memory for landmark-direction associations. Our findings highlight the benefits of using human-centred technologies that – as opposed to current navigation systems – promote the encoding and memorability of spatial information during navigation, and have the potential to train human spatial navigation abilities in the long term as a countermeasure toward GPS cognitive deskilling of population