47 research outputs found
Association of education with dietary intake among young adults in the bi-ethnic Coronary Artery Risk Development in Young Adults (CARDIA) cohort
OBJECTIVE: To examine associations of changes in dietary intake with education in young black and white men and women.
DESIGN: The Coronary Artery Risk Development in Young Adults (CARDIA) study, a multi-centre population-based prospective study. Dietary intake data at baseline and year 7 were obtained from an extensive nutritionist-administered diet history questionnaire with 700 items developed for CARDIA.
SETTING: Participants were recruited in 1985-1986 from four sites: Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California.
SUBJECTS: Participants were from a general community sample of 703 black men (BM), 1006 black women (BW), 963 white men (WM) and 1054 white women (WW) who were aged 18-30 years at baseline. Analyses here include data for baseline (1985-1986) and year 7 (1992-1993).
RESULTS: Most changes in dietary intake were observed among those with high education (\u3eor=12 years) at both examinations. There was a significant decrease in intake of energy from saturated fat and cholesterol and a significant increase in energy from starch for each race-gender group (P\u3c0.001). Regardless of education, taste was considered an important influence on food choice.
CONCLUSION: The inverse relationship of education with changes in saturated fat and cholesterol intakes suggests that national public health campaigns may have a greater impact among those with more education
Biobanking, consent, and commercialization in international genetics research: the Type 1 Diabetes Genetics Consortium
Background and Purpose This article describes several ethical, legal, and social issues typical of
international genetics biobanking, as encountered in the Type 1 Diabetes Genetics Consortium
(T1DGC)
Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories
Background and Purpose Three network laboratories measured antibodies to islet autoantigens.
Antibodies to glutamic acid decarboxylase (GAD65 [GADA]) and the intracellular
portion of protein tyrosine phosphatase (IA-2ic [IA-2A]) were
measured by similar, but not identical, methods in samples from participants in
the Type 1 Diabetes Genetics Consortium (T1DGC)
Quality control of phenotypic forms data in the Type 1 Diabetes Genetics Consortium
Background When collecting phenotypic data in clinics across the globe, the Type 1 Diabetes
Genetics Consortium (T1DGC) used several techniques that ensured consistency, completeness, and
accuracy of the data
HLA genotyping in the international Type 1 Diabetes Genetics Consortium
Background Although human leukocyte antigen (HLA) DQ and
DR loci appear to confer the strongest genetic risk for
type 1 diabetes, more detailed information is required for other loci within the
HLA region to understand causality and stratify additional risk factors. The
Type 1 Diabetes Genetics Consortium (T1DGC) study design included
high-resolution genotyping of HLA-A, B,
C, DRB1, DQ, and
DP loci in all affected sibling pair and trio families, and
cases and controls, recruited from four networks worldwide, for analysis with
clinical phenotypes and immunological markers
Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC)
Background and Purpose The Type 1 Diabetes Genetics Consortium (T1DGC) is an
international project whose primary aims are to: (a) discover genes that modify
type 1 diabetes risk; and (b) expand upon the existing genetic resources for
type 1 diabetes research. The initial goal was to collect 2500 affected sibling
pair (ASP) families worldwide
Regional disparities in the incidence of elevated blood pressure among young adults: the CARDIA study
BACKGROUND: Within the United States, little is known about regional disparities in blood pressure (BP), their changes over time, or explanations for their existence.
METHODS AND RESULTS: A population-based cohort of 5115 black and white men and women, 18 to 30 years old in 1985-1986 (balanced on age, race, sex, and education), was followed up for 7 years in four centers: Birmingham, Ala; Chicago, Ill; Minneapolis, Minn; and Oakland, Calif. Differences in elevated BP (EBP) prevalence among centers at years 0, 2, 5, and 7 and in 7-year incidence of EBP were assessed. Sociodemographic and dietary variables, physical activity, weight, smoking, and alcohol were considered. At year 0, no regional differences were seen. Seven years later, there was marked variability in prevalence of EBP overall and for both black and white men, from a low in Chicago (9% for black men and 5% for white men) to a high in Birmingham (25% for black men and 14% for white men). Birmingham also had the highest 7-year incidence (11%) and overall prevalence at year 7 (14%). The adjusted odds ratios, with Birmingham as referent (95% CIs), for 7-year incidence of EBP overall were 0.38 (0.24, 0.60) for Chicago, 0.37 (0.24, 0.57) for Minneapolis, and 0.74 (0.52, 1.07) for Oakland.
CONCLUSIONS: Regional disparities are absent at baseline but become apparent as the cohort ages. These differences are not fully explained by the available behavioral and sociodemographic characteristics
Serum adiponectin in young adults - Interactions with central adiposity, circulating levels of glucose, and insulin resistance: The CARDIA study
Purpose To study adiponectin, a circulating adipocytokine secreted by adipocytes inversely associated with diabetes and insulin resistance, and factors affecting its levels in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Methods Adiponectin in serum was measured by radioimmunoassay in 3355 participants (ages: 23-45 years) categorized by fasting glucose levels as normal, impaired fasting glucose, or diabetes mellitus. Results Levels of adiponectin were higher in women, in white participants, and with age. Waist circumference, estimating visceral fat, strongly and inversely correlated with levels of adiponectin, more than body mass index. Adiponectin values adjusted for gender and race were lower with higher fasting glucose values in the normal range and still lower with impaired fasting glucose and untreated diabetes mellitus, even further adjusting for waist circumference and fasting insulin levels (p \u3c 0.0001). Gender- and race-adjusted adiponectin levels were inversely associated with insulin resistance at year 15 and with insulin resistance measured 15 years previously and with its change from baseline to year 15 (p \u3c 0.0001). Conclusions These data suggest complex and significant physiologic interactions among circulating levels of adiponectin and measures of insulin action throughout young adulthood, even from several years earlier. Central obesity, as measured with waist circumference, is a primary factor affecting levels of circulating adiponectin. Furthermore, levels of glucose and levels of adiponectin may directly influence one another. © 2004 Elsevier Inc. All rights reserved