Capital Punishment in Ohio: Aggravating Circumstances

The state of Ohio enacted a new death penalty statute which became effective October 19, 1981. As of January 18, 1983, eighty-three defendants had been indicted under the new statute. It is, therefore, both necessary and timely to evaluate Ohio\u27s statutory delineation of who may die and its effect for compliance with constitutional mandates. This Note sets forth the hypotheses and supporting legal authority for analyzing Ohio\u27s statutory aggravating circumstances individually and in the aggregate on equal protection and procedural due process grounds

Capital Punishment in Ohio: Aggravating Circumstances

The state of Ohio enacted a new death penalty statute which became effective October 19, 1981. As of January 18, 1983, eighty-three defendants had been indicted under the new statute. It is, therefore, both necessary and timely to evaluate Ohio\u27s statutory delineation of who may die and its effect for compliance with constitutional mandates. This Note sets forth the hypotheses and supporting legal authority for analyzing Ohio\u27s statutory aggravating circumstances individually and in the aggregate on equal protection and procedural due process grounds

Linking groundwater quality to soil properties, landscape characteristics, and farm practice a spatial analysis of the "groundwater characterization in R.M. of Leroy" dataset

Non-Peer ReviewedThe objectives of this study are to determine the source and extent of nitrogen and phosphorus contamination in the Rural Municipality of Leroy, and the most likely modes of contaminant transport, using only existing data. The analysis was conducted without the benefit of further data collection. Data types include information about well properties, land use, farm management practices and selected water quality parameters, obtained from the original Leroy well water study ("Groundwater Characterization in RM of Leroy", March 2001.) Soils databases, Canadian census information, topographic data and hydrographic data were also drawn upon to analyze water quality data in a GIS environment

Associations Between Social Media and Well-Being and Sleep Quality in Medical and Health Professions

This study was conducted to assess associations between social media use and overall well-being and sleep quality in medical and health professions graduate students. A cross-sectional survey was distributed to examine demographic information, social media use, and health behaviors and outcomes. Logistic regression analysis was conducted to examine the relationships between sleep quality and potential covariates and/or independent variables, while proportional odds regression was performed to analyze potential associations between emotional wellbeing and independent variables. Survey respondents were more likely to have a low or depressed mood if they used social media as a way to help them sleep [odds ratio=2.1, 95% confidence interval = (1.0, 4.2)]. Participants who used social media to help them sleep also had poorer sleep quality than those who did not use social media for that purpose [odds ratio=2.3, 95% confidence interval= (1.1, 4.7)]. In addition, individuals who used social media to obtain health-related advice or information were 2.8 times [95% confidence interval= (1.4, 5.8)] more likely to have poor sleep quality compared to those who did not use social media for health-related advice or information. These study results expound upon the relationship between social media use and health outcomes in medical and graduate students

Genistein Has Antiviral Activity against Herpes B Virus and Acts Synergistically with Antiviral Treatments to Reduce Effective Dose

Herpes B virus is a deadly zoonotic agent that can be transmitted to humans from the macaque monkey, an animal widely used in biomedical research. Currently, there is no cure for human B virus infection and treatments require a life-long daily regimen of antivirals, namely acyclovir and ganciclovir. Long-term antiviral treatments have been associated with significant debilitating side effects, thus, there is an ongoing search for alternative efficacious antiviral treatment. In this study, the antiviral activity of genistein was quantified against B virus in a primary cell culture model system. Genistein prevented plaque formation of B virus and reduced virus production with an IC50 value of 33 and 46 μM for human and macaque fibroblasts, respectively. Genistein did not interfere directly with viral entry, but instead targeted an event post-viral replication. Finally, we showed that genistein could be used at its IC50 concentration in conjunction with both acyclovir and ganciclovir to reduce their effective dose against B virus with a 93% and 99% reduction in IC50 values, respectively. The results presented here illuminate the therapeutic potential of genistein as an effective antiviral agent against B virus when used alone or in combination with current antiviral therapies

Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis.

This study investigated the antispasticity potential of Sativex in mice. Chronic relapsing experimental allergic encephalomyelitis was induced in adult ABH mice resulting in hind limb spasticity development. Vehicle, Sativex, and baclofen (as a positive control) were injected intravenously and the "stiffness" of limbs assessed by the resistance force against hind limb flexion. Vehicle alone caused no significant change in spasticity. Baclofen (5 mg/kg) induced approximately a 40% peak reduction in spasticity. Sativex dose dependently reduced spasticity; 5 mg/kg THC + 5 mg/kg CBD induced approximately a 20% peak reduction; 10 mg/kg THC + 10 mg/kg CBD produced approximately a 40% peak reduction in spasticity. Sativex has the potential to reduce spasticity in an experimental mouse model of multiple sclerosis (MS). Baclofen reduced spasticity and served as a positive control. Sativex (10 mg/kg) was just as effective as baclofen, providing supportive evidence for Sativex use in the treatment of spasticity in MS

Innovation and opportunity: review of the UK’s national AI strategy

The publication of the UK’s National Artificial Intelligence (AI) Strategy represents a step-change in the national industrial, policy, regulatory, and geo-strategic agenda. Although there is a multiplicity of threads to explore this text can be read primarily as a ‘signalling’ document. Indeed, we read the National AI Strategy as a vision for innovation and opportunity, underpinned by a trust framework that has innovation and opportunity at the forefront. We provide an overview of the structure of the document and offer an emphasised commentary on various standouts. Our main takeaways are: Innovation First: a clear signal is that innovation is at the forefront of UK’s data priorities. Alternative Ecosystem of Trust: the UK’s regulatory-market norms becoming the preferred ecosystem is dependent upon the regulatory system and delivery frameworks required. Defence, Security and Risk: security and risk are discussed in terms of utilisation of AI and governance. Revision of Data Protection: the signal is that the UK is indeed seeking to position itself as less stringent regarding data protection and necessary documentation. EU Disalignment—Atlanticism?: questions are raised regarding a step back in terms of data protection rights. We conclude with further notes on data flow continuity, the feasibility of a sector approach to regulation, legal liability, and the lack of a method of engagement for stakeholders. Whilst the strategy sends important signals for innovation, achieving ethical innovation is a harder challenge and will require a carefully evolved framework built with appropriate expertise