6,167 research outputs found
In-Medium Modifications of Scalar Charm Mesons in Nuclear Matter
Employing QCD sum rules the in-medium modifications of scalar charm mesons in
a cold nuclear matter environment are estimated. The mass splitting of
D*-D*-bar is quantified.Comment: Talk given at QCD 10, Montpelier, France, 27.06.-05.07.201
Millimolar concentrations of free magnesium enhance exocytosis from permeabilized rat pheochromocytoma (PC 12) cells
The role of Mg2+ during the final steps of exocytosis was investigated using rat pheochromocytoma cells (PC12) permeabilized with bacterial pore forming toxins. Concentrations of free Mg2+ between 0.2 and 2 mM slightly lowered the basal but greatly enhanced the [3H]dopamine release elicited by 8 μM free Ca2+. Maximal effects were obtained at approximately 1 mM free Mg2+. At higher concentrations Mg2+ was less potent. Similar effects of Mg2+ were obtained in cells permeabilized either for small molecules (by α-toxin) or for large ones (by streptolysin O). It is concluded that millimolar concentrations of cytoplasmic Mg2+ play an important role in Ca2+ triggered exocytosis
Reductive chain separation of botulinum A toxin — a prerequisite to its inhibitory action on exocytosis in chromaffin cells
Cleavage of the disulfide bond linking the heavy and the light chains of tetanus toxin is necessary for its inhibitory action
on exocytotic release ofcatecholamines from permeabi1ized chromaffin cells [(1989) FEBS Lett. 242, 245-248; (1989) J.
Neurochern., in press]. The related botulinum A toxin also consists of a heavy and a light chain linked by a disulfide
bond. The actions ofboth neurotoxins on exocytosis were presently compared using streptolysin O-permeabilized bovine
adrenal chromaffin cells. Botulinum A toxin inhibited Ca2 +-stimulated catecholamine release from these cells. Addition
of dithiothreitollowered the effective doses to values below 5 nM. Under the same conditions, the effective doses of tetanus
toxin were decreased by a factor of five. This indicates that the interchain S-S bond of botulinum A toxin must
also be split before the neurotoxin can exert its effect on exocytosis
Four-quark condensates in open-charm chiral QCD sum rules
Recently, in Hilger et al. (2011) [1] QCD sum rules for chiral partners in
the open-charm meson sector have been presented at nonzero baryon net density
or temperature up to and including mass dimension 5. Referring to this, details
concerning the cancelation of infrared divergences are presented and important
technical and conceptional ingredients for an incorporation of four-quark
condensates beyond factorization and of other mass dimension 6 condensates are
collected.Comment: 7 pages, 5 figures, conference proceedin
- …