Additional file 1: of VARPRISM: incorporating variant prioritization in tests of de novo mutation association

Contains: Supplementary Methods, Tables S1–S3, and Figures S1–S3. (DOCX 389 kb

Enrichment of GWAS Catalog Terms.

A. Pan-ancestry Results. B. European Ancestry Results.</p

Heritability of Suicidal Ideation in the Million Veterans Program and Genetic Correlation with Frequent Comorbid Conditions.

Heritability of Suicidal Ideation in the Million Veterans Program and Genetic Correlation with Frequent Comorbid Conditions.</p

Genome-wide Significant Loci for Suicidal Ideation Conditioned on Comorbid Conditions.

Genome-wide Significant Loci for Suicidal Ideation Conditioned on Comorbid Conditions.</p

Defining Suicidal Ideation and Suicide Attempt Phenotypes in the MVP.

This section provides more detailed information regarding how the suicide phenotypes were defined for analysis. (DOCX)</p

Ancestry-specific allele frequencies for the Genome-wide Significant Loci in Table 2.

Ancestry-specific allele frequencies for the Genome-wide Significant Loci in Table 2.</p

Single Marker GWAS Results for Suicidal Ideation in the Million Veterans Program.

A. African Ancestry Results, B. Asian Ancestry Results, C. Hispanic Ancestry Results. (TIF)</p

MVP-based Suicidal Ideation Polygenic Risk Scores (PRS) Predicting Suicide Attempts+Ideation in the MIRECC cohort.

A. European Ancestry Results, B. African Ancestry Results. (TIF)</p

Gene-based Manhattan Plots.

A. Pan-ancestry Results. B. European Ancestry Results.</p

Forest plots for genome-wide significant loci.

A. Chromosome 9 locus from Pan-Ancestry Analysis, B. Chromosome 16 locus from Pan-Ancestry Analysis, C. Chromosome 2 locus from Pan-Ancestry Analysis, D. Chromosome 6 locus from Pan-Ancestry Analysis, E. Chromosome 9 locus for European-Ancestry Analysis, F. Chromosome 6 locus from European-Ancestry Analysis. These plots provide the point estimates and confidence intervals at each locus by ancestry and for the meta-analysis. (TIF)</p