Morphological and Clinical Aspects of Aberrant Subclavian Artery: Single Center Multidedector Computed Tomography Based Study

Aim: Aberrant subclavian artery (ASA) anomalies are the most common aortic arch malformations. Incidence of these malformations increases with widespread use of computed tomography (CT). Our aim in this study was to investigate the relationship between ASA malformations, gender, age and reasons for admission, and arcus aorta (AA), ASA diameters and AA/ASA diameter ratios.Materials and Methods: A total 74 patients with ASA were evaluated by thorax CT retrospectively. Patients were divided into aberrant right (ARSA) and left (ALSA) subclavian artery groups. Age, gender, reasons for application, ASA and AA diameters and AA/ASA ratios were evaluated between the groups. Correlations of ASA and AA diameters with age were also evaluated.Results: 70 of the patients (94.5%) had ARSA, 4 of the patients (5.4%) had ALSA. There was no statistical relationship between gender (p=0.394), age (p=0.443) and reasons for application (p=0.322) between groups. There was no statistical relationship between ASA diameter (p=0.127), AA diameter (p=0.728) and AA/ASA ratio (p=0.339) between groups. There was weak positive correlation with age and diameter of AA (r=0.379, p=0.001), but not with ASA diameter (p=0.059). Moderate positive correlation (r=0.573, p<0.001) was detected between diameters of AA and ASA.Conclusion: ASA malformations are the most common incidentally detected malformations with increased use of CT. These malformations are not related to age, gender and reasons for application

The influence of aspirin resistance on non-fatal coronary events following percutaneous coronary interventions

WOS: 000274068200007Introduction: Aspirin resistance is associated with unfavourable prognosis, including a higher incidence of myocardial infarction, stroke, and cardiovascular death among stable cardiovascular patients, a higher incidence of re-occlusion after peripheral angioplasty, and myonecrosis following elective percutaneous coronary interventions (PCI). The objective of this study was to evaluate the relationship between aspirin resistance and non-fatal clinical endpoints during the long term follow-up following successful PCI, Material and methods: A total of 100 subjects with angiographically diagnosed coronary artery disease and treated with elective, non-urgent intracoronary stent implantation between October 2001 and June 2002 were enrolled in the study. All patients were under regular aspirin (300 mg) treatment. PFA-100 analyzer was used to assess the platelet functions. Aspirin resistance was defined as a collagen/epinephrine closure time (CTCEPI) < 186 s. The study end-point was the composite of non-fatal coronary events which included non-fatal MI, coronary artery bypass graft surgery (CABG) or repeat PCI, during the 2-year follow-up period after the index PCL Results: The incidence of aspirin resistance was found to be significantly higher (p = 0.021) in patients with non-fatal coronary events (22.4%) compared to those who did not have (5.9%). Aspirin resistance was found to be an independent risk factor for non-fatal coronary events after adjusted for other potential risk factors (p = 0.019). Conclusions: Despite regular treatment with aspirin, the incidence of aspirin resistance was significantly higher in patients who developed non-fatal coronary events on long term follow-up following elective PCI. Thus, these findings suggest that aspirin resistance might be an important risk factor that could affect the outcome following PCIs