Error threshold in simple landscapes

We consider the quasispecies description of a population evolving in both the "master sequence" landscape (where a single sequence is evolutionarily preferred over all others) and the REM landscape (where the fitness of different sequences is an independent, identically distributed, random variable). We show that, in both cases, the error threshold is analogous to a first order thermodynamical transition, where the overlap between the average genotype and the optimal one drops discontinuously to zero.Comment: 10 pages and 2 figures, Plain LaTe

On topological defect formation in the process of symmetry breaking phase transitions

By resorting to some results in quantum field theories with spontaneous breakdown of symmetry we show that an explanation based on microscopic dynamics can be given of the fact that topological defect formation is observed during the process of non-equilibrium phase transitions characterized by a non-zero order parameter. We show that the Nambu-Goldstone particle acquires an effective non-zero mass due to the boundary (finite volume) effects and this is related with the size of the defect. We also relate such volume effect with temperature effect.Comment: 12 pages, no figure

A viability criterion for modified gravity with an extra force

A recently proposed theory of modified gravity with an explicit ``anomalous'' coupling of the Ricci curvature to matter is discussed, and an inequality is derived which expresses a necessary and sufficient condition to avoid the notorius Dolgov-Kawasaki instability.Comment: 4 latex pages, to appear in Phys. Rev.

Understanding the subjective experiences of memory concern and MCI diagnosis: A scoping review.

INTRODUCTION: Many older people experience memory concerns; a minority receive a diagnosis of Mild Cognitive Impairment (MCI) or Subjective Cognitive decline (SCD). There are concerns that medicalisation of MCI and memory concern may fail to acknowledge subjective experiences. AIM: We explore the meaning individuals give to their memory concerns, with or without a diagnosis of MCI and SCD. METHOD: We scoped literature exploring subjective experiences of memory concern, with or without a diagnosis of MCI or SCD. We searched CINAHL, PsycINFO and MEDLINE in March 2020, and updated in Sept 2021.We used (Arksey & O'Malley, 2005) framework to guide our scoping review method and thematic analysis to analyse our findings. RESULTS: We screened 12,033 search results reviewing the full texts of 92 papers. We included 24 papers, including a total of 453 participants, the majority of whom were female, from White ethnic majority populations (or from studies where ethnicity was not identified) with high levels of education. In 15 out of 24 studies, 272 participants were diagnosed with MCI. We identified two themes; Making a diagnosis personal and Remembering not to forget. We found that subjective experiences include normative comparison with others of the same age and responses including fear, relief, and acceptance, but culminating in uncertainty. CONCLUSION: Drawing upon sociology, we highlight the subjective experiences of living with memory concerns, SCD and an MCI diagnosis. We identify a gap between the intended purpose of diagnostic labels to bring understanding and certainty and the lived experiences of those ascribed them

RNA secondary structure formation: a solvable model of heteropolymer folding

The statistical mechanics of heteropolymer structure formation is studied in the context of RNA secondary structures. A designed RNA sequence biased energetically towards a particular native structure (a hairpin) is used to study the transition between the native and molten phase of the RNA as a function of temperature. The transition is driven by a competition between the energy gained from the polymer's overlap with the native structure and the entropic gain of forming random contacts. A simplified Go-like model is proposed and solved exactly. The predicted critical behavior is verified via exact numerical enumeration of a large ensemble of similarly designed sequences.Comment: 4 pages including 2 figure

Does Magnetic Charge Imply a Massive Photon ?

In Abelian theories of monopoles the magnetic charge is required to be enormous. Using the electric-magnetic duality of electromagnetism it is argued that the existence of such a large, non-perturbative magnetic coupling should lead to a phase transition where magnetic charge is permanently confined and the photon becomes massive. The apparent masslessness of the photon could then be used as an argument against the existence of such a large, non-perturbative magnetic charge. Finally it is shown that even in the presence of this dynamical mass generation the Cabbibo-Ferrari formulation of magnetic charge gives a consistent theory.Comment: 10 pages LaTe

Measurement of the Higgs Boson Mass with a Linear e+e- Collider

The potential of a linear e+e- collider operated at a centre-of-mass energy of 350 GeV is studied for the measurement of the Higgs boson mass. An integrated luminosity of 500 fb-1 is assumed. For Higgs boson masses of 120, 150 and 180 GeV the uncertainty on the Higgs boson mass measurement is estimated to be 40, 65 and 70 MeV, respectively. The effects of beam related systematics, namely a bias in the beam energy measurement, the beam energy spread and the luminosity spectrum due to beamstrahlung, on the precision of the Higgs boson mass measurement are investigated. In order to keep the systematic uncertainty on the Higgs boson mass well below the level of the statistical error, the beam energy measurement must be controlled with a relative precision better than 10-4.Comment: 19 pages, 10 Figure

Probing the Higgs mechanism via γγ→W+W−\gamma\gamma\to W^+W^-

We investigate the sensitivity of the reaction $\gamma\gamma\to W^+W^-$ to the Higgs sector based on the complete one-loop corrections in the minimal Standard Model and the gauged non-linear $\sigma$-model. While this sensitivity is very strong for the suppressed cross-section of equally polarized photons and longitudinal W bosons, it is only marginal for the dominant mode of transverse polarizations. The corrections within the $\sigma$-model turn out to be UV-finite in accordance with the absence of \log\MH terms in the Standard Model with a heavy Higgs boson.Comment: 12 pages uuencoded postscrip

The Triple Higgs Boson Self-Coupling at Future Linear e+e- Colliders Energies: ILC and CLIC

We analyzed the triple Higgs boson self-coupling at future $e^{+}e^{-}$ colliders energies, with the reactions $e^{+}e^{-}\to b \bar b HH, t \bar t HH$. We evaluate the total cross-sections for both $b\bar bHH$ and $t\bar tHH$, and calculate the total number of events considering the complete set of Feynman diagrams at tree-level. We vary the triple coupling $\kappa\lambda_{3H}$ within the range $\kappa=-1$ and +2. The numerical computation is done for the energies expected to be available at a possible Future Linear $e^{+}e^{-}$ Collider with a center-of-mass energy $800, 1000, 1500$ $GeV$ and a luminosity 1000 $fb^{-1}$. Our analysis is also extended to a center-of-mass energy 3 $TeV$ and luminosities of 1000 $fb^{-1}$ and 5000 $fb^{-1}$. We found that for the process $e^{+}e^{-}\to b \bar b HH$, the complete calculation differs only by 3% from the approximate calculation $e^{+}e^{-}\to ZHH(Z\to b\bar b)$, while for the process $e^{+}e^{-}\to t \bar tHH$, the expected number of events, considering the decay products of both $t$ and $H$, is not enough to obtain an accurate determination of the triple Higgs boson self-coupling.Comment: 19 pages, 12 figure

How to relate the oscillator and Coulomb systems on spheres and pseudospheres?

We show that the oscillators on a sphere and pseudosphere are related, by the so-called Bohlin transformation, with the Coulomb systems on the pseudosphere: the even states of an oscillator yields the conventional Coulomb system on pseudosphere, while the odd states yield the Coulomb system on pseudosphere in the presence of magnetic flux tube generating half spin. In the higher dimensions the oscillator and Coulomb(-like) systems are connected in the similar way. In particular, applying the Kustaanheimo-Stiefel transformation to the oscillators on sphere and pseudosphere, we obtained the preudospherical generalization of MIC-Kepler problem describing three-dimensional charge-dyon system.Comment: 12 pages, Based on talk given at XXIII Colloquium on Group Theoretical Methods in Physics (July 31-August 5, 2000, Dubna