13 research outputs found

    Arukikata Travelogue Dataset with Geographic Entity Mention, Coreference, and Link Annotation

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    Geoparsing is a fundamental technique for analyzing geo-entity information in text. We focus on document-level geoparsing, which considers geographic relatedness among geo-entity mentions, and presents a Japanese travelogue dataset designed for evaluating document-level geoparsing systems. Our dataset comprises 200 travelogue documents with rich geo-entity information: 12,171 mentions, 6,339 coreference clusters, and 2,551 geo-entities linked to geo-database entries

    DOCK2 is involved in the host genetics and biology of severe COVID-19

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    「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

    COST-SENSITIVE STRUCTURED PERCEPTRON INCORPORATING CATEGORY HIERARCHY FOR NAMED ENTITY RECOGNITION

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    Named Entity Recognition (NER) is a fundamental natural language processing task for the identifi cation and classifi cation of expressions into predefi ned categories, such as person and organization. Existing NER systems usually target about 10 categories and do not incorporate analysis of category relations. However, categories often belong naturally to some predefi ned hierarchy. In such cases, the distance between categories in the hierarchy becomes a rich source of information that can be exploited. This is intuitively useful particularly when the categories are numerous. On that account, this paper proposes an NER approach that can leverage category hierarchy information by introducing, in the structured perceptron framework, a cost function more strongly penalizing category predictions that are more distant from the correct category in the hierarchy. Experimental results on the GENIA biomedical text corpus indicate the effectiveness of the proposed approach as compared with the case where no cost function is utilized. In addition, the proposed approach demonstrates the superior performance over a representative work using multi-class support vector machines on the same corpus. A possible direction to further improve the proposed approach is to investigate more elaborate cost functions than a simple additive cost adopted in this work.

    User-Generated Text Corpus for Evaluating Japanese Morphological Analysis and Lexical Normalization

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    Proceedings of the 2021 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies,Online,NAACLMorphological analysis (MA) and lexical normalization (LN) are both important tasks for Japanese user-generated text (UGT). To evaluate and compare different MA/LN systems, we have constructed a publicly available Japanese UGT corpus. Our corpus comprises 929 sentences annotated with morphological and normalization information, along with category information we classified for frequent UGT-specific phenomena. Experiments on the corpus demonstrated the low performance of existing MA/LN methods for non-general words and non-standard forms, indicating that the corpus would be a challenging benchmark for further research on UGT

    Cost-sensitive structured perceptron incorporating category hierarchy for named entity recognition

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    Named Entity Recognition (NER) is a fundamental natural language processing task for the identification and classification of expressions into predefined categories, such as person and organization.Existing NER systems usually target about 10 categories and do not incorporate analysis of category relations.However, categories often belong naturally to some predefined hierarchy.In such cases, the distance between categories in the hierarchy becomes a rich source of information that can be exploited.This is intuitively useful particularly when the categories are numerous.On that account, this paper proposes an NER approach that can leverage category hierarchy information by introducing, in the structured perceptron framework, a cost function more strongly penalizing category predictions that are more distant from the correct category in the hierarchy.Experimental results on the GENIA biomedical text corpus indicate the effectiveness of the proposed approach as compared with the case where no cost function is utilized. In addition, the proposed approach demonstrates the superior performance over a representative work using multi-class support vector machines on the same corpus.A possible direction to further improve the proposed approach is to investigate more elaborate cost functions than a simple additive cost adopted in this work

    Optimal Word Segmentation for Neural Machine Translation into Dravidian Languages

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    Dravidian languages, such as Kannada and Tamil, are notoriously difficult to translate by state-of-the-art neural models. This stems from the fact that these languages are morphologically very rich as well as being low-resourced. In this paper, we focus on subword segmentation and evaluate Linguistically Motivated Vocabulary Reduction (LMVR) against the more commonly used SentencePiece (SP) for the task of translating from English into four different Dravidian languages. Additionally we investigate the optimal subword vocabulary size for each language. We find that SP is the overall best choice for segmentation, and that larger dictionary sizes lead to higher translation quality
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