Decline of maternally-derived Neut-Ab to EV71 in 37 infants in the first year of life.

<p>The scatter plot shows Neut-Ab titres in 37 individual infants from the time of birth to 12 months. These infants all had Neut-Ab titre to Ev71 ≥80 at birth. The infant having a detectable titre at 6 months had the highest Ab titre at birth (1280). Maternal Neut-Ab to EV71 were not detected in these infants at 9 and 12 months of age. The dashed line represents the limit of detection of the assay.</p

EV71 Neut-Ab profiles in 8 representative infants.

<p>Shown in panel A are representative Neut-Ab profiles from 4 infants (out of a total of 17 infants) with incident EV71 seroconversion in the first year of life. Similarly, shown in panel B are representative Neut-Ab profiles from 4 infants (out of a total of 37 infants) with incident EV71 seroconversion in the second year of life. The dashed line represents the assay limit of detection.</p

EV71 seroincidence in infants and young children, HCMC, Viet Nam.

<p>EV71 seroincidence in infants and young children, HCMC, Viet Nam.</p

The relationship of EV71 neutralizing antibodies levels/seropositivity and age.

<p>Shown in A are age-specific seroprevalence to EV71 of Ho Chi Minh City, Viet Nam. The number above each bar shows the proportion of participants with detectable EV71 Neut-Ab in their plasma. Shown in B are levels of Neut-Ab in relation to age amongst those that are positive. The levels of Neut-Ab against EV71 in infants at 12 month-old were significantly higher than that in 24 m children (P = 0.0015), in 5–15 yrs group and 18–38 yrs group (P<0.0001) (Mann-Whitney U test). Noted that 18–38 yrs refers to cord blood. Data are shown as medians (5–95% percentile range). The dashed line represents the assay limit of detection.</p