100 research outputs found
Bundles of Interacting Strings in Two Dimensions
Bundles of strings which interact via short-ranged pair potentials are
studied in two dimensions. The corresponding transfer matrix problem is solved
analytically for arbitrary string number N by Bethe ansatz methods. Bundles
consisting of N identical strings exhibit a unique unbinding transition. If the
string bundle interacts with a hard wall, the bundle may unbind from the wall
via a unique transition or a sequence of N successive transitions. In all
cases, the critical exponents are independent of N and the density profile of
the strings exhibits a scaling form that approaches a mean-field profile in the
limit of large N.Comment: 8 pages (latex) with two figure
Fluctuation Pressure of a Stack of Membranes
We calculate the universal pressure constants of a stack of N membranes
between walls by strong-coupling theory. The results are in very good agreement
with values from Monte-Carlo simulations.Comment: Author Information under
http://www.physik.fu-berlin.de/~kleinert/institution.html Latest update of
paper also at http://www.physik.fu-berlin.de/~kleinert/31
Coiling Instability of Multilamellar Membrane Tubes with Anchored Polymers
We study experimentally a coiling instability of cylindrical multilamellar
stacks of phospholipid membranes, induced by polymers with hydrophobic anchors
grafted along their hydrophilic backbone. Our system is unique in that coils
form in the absence of both twist and adhesion. We interpret our experimental
results in terms of a model in which local membrane curvature and polymer
concentration are coupled. The model predicts the occurrence of maximally tight
coils above a threshold polymer occupancy. A proper comparison between the
model and experiment involved imaging of projections from simulated coiled
tubes with maximal curvature and complicated torsions.Comment: 11 pages + 7 GIF figures + 10 JPEG figure
Interactions between proteins bound to biomembranes
We study a physical model for the interaction between general inclusions
bound to fluid membranes that possess finite tension, as well as the usual
bending rigidity. We are motivated by an interest in proteins bound to cell
membranes that apply forces to these membranes, due to either entropic or
direct chemical interactions. We find an exact analytic solution for the
repulsive interaction between two similar circularly symmetric inclusions. This
repulsion extends over length scales of order tens of nanometers, and contrasts
with the membrane-mediated contact attraction for similar inclusions on
tensionless membranes. For non circularly symmetric inclusions we study the
small, algebraically long-ranged, attractive contribution to the force that
arises. We discuss the relevance of our results to biological phenomena, such
as the budding of caveolae from cell membranes and the striations that are
observed on their coats.Comment: 22 pages, 2 figure
Fluctuation spectrum of fluid membranes coupled to an elastic meshwork: jump of the effective surface tension at the mesh size
We identify a class of composite membranes: fluid bilayers coupled to an
elastic meshwork, that are such that the meshwork's energy is a function
\textit{not} of the real microscopic membrane area ,
but of a \textit{smoothed} membrane's area , which corresponds to the
area of the membrane coarse-grained at the mesh size . We show that the
meshwork modifies the membrane tension both below and above the scale
, inducing a tension-jump . The
predictions of our model account for the fluctuation spectrum of red blood
cells membranes coupled to their cytoskeleton. Our results indicate that the
cytoskeleton might be under extensional stress, which would provide a means to
regulate available membrane area. We also predict an observable tension jump
for membranes decorated with polymer "brushes"
Bending elasticity of a curved amphiphilic film decorated anchored copolymers: a small angle neutron scattering study
Microemulsion droplets (oil in water stabilized by a surfactant film) are
progressively decorated with increasing amounts of poly ethylene- oxide (PEO)
chains anchored in the film by the short aliphatic chain grafted at one end of
the PEO chain . The evolution of the bending elasticity of the surfactant film
with increasing decoration is deduced from the evolution in size and
polydispersity of the droplets as reflected by small angle neutron scattering.
The optimum curvature radius decreases while the bending rigidity modulus
remains practically constant. The experimental results compare well with the
predictions of a model developed for the bending properties of a curved film
decorated by non-adsorbing polymer chains, which takes into account, the finite
curvature of the film and the free diffusion of the chains on the film.Comment: 30 June 200
Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner
Major depressive disorder is the main cause of disability worldwide with imperfect treatment options. However, novel therapeutic approaches are currently discussed, from augmentation strategies to novel treatments targeting the immune system or the microbiome-gut-brain axis. Therefore, we examined the potential beneficial effects of minocycline, a tetracycline antibiotic with pleiotropic, immunomodulatory action, alone or as augmentation of escitalopram on behavior, prefrontal microglial density, and the gut microbiome in rats selectively bred for high anxiety-like behavior (HAB). We show that concomitant with their high innate anxiety and depression, HABs have lower microglial numbers in the infralimbic and prelimbic prefrontal cortex and an altered gut microbiota composition compared with controls. Three weeks of minocycline treatment alleviated the depressive-like phenotype, further reduced microglial density, exclusively in male HAB rats, and reduced plasma concentrations of pro-inflammatory cytokines. However, coadministration of escitalopram, which had no effect alone, prevented these minocycline-induced effects. Moreover, minocycline led to a robust shift in cecal microbial composition in both HABs and rats nonselected for anxiety-like behavior. Minocycline markedly increased relative abundance of Lachnospiraceae and Clostridiales Family XIII, families known for their butyrate production, with a corresponding increase and positive correlation in plasma 3-OH-butyrate levels in a trait-dependent manner. Thus, our data suggest that the antidepressant effect of minocycline is sex- and trait-dependent, associated with a reduced microglial number in the prefrontal cortex, and with changes in microbial composition and their metabolites. These results further support the microbiomegut-brain axis as potential target in the treatment of depression
Synthesis of Bio-Compatible SPION–based Aqueous Ferrofluids and Evaluation of RadioFrequency Power Loss for Magnetic Hyperthermia
Bio-compatible magnetic fluids having high saturation magnetization find immense applications in various biomedical fields. Aqueous ferrofluids of superparamagnetic iron oxide nanoparticles with narrow size distribution, high shelf life and good stability is realized by controlled chemical co-precipitation process. The crystal structure is verified by X-ray diffraction technique. Particle sizes are evaluated by employing Transmission electron microscopy. Room temperature and low-temperature magnetic measurements were carried out with Superconducting Quantum Interference Device. The fluid exhibits good magnetic response even at very high dilution (6.28 mg/cc). This is an advantage for biomedical applications, since only a small amount of iron is to be metabolised by body organs. Magnetic field induced transmission measurements carried out at photon energy of diode laser (670 nm) exhibited excellent linear dichroism. Based on the structural and magnetic measurements, the power loss for the magnetic nanoparticles under study is evaluated over a range of radiofrequencies
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