Three-nucleon interactions: dynamics

A discussion is presented of the dynamics underlying three-body nuclear forces, with emphasis on changes which occurred over several decades.Comment: Talk given at the FM50 symposium, Tokyo, October 200

Three-nucleon interactions: A frontier in nuclear structure

Three-nucleon interactions are a frontier in understanding and predicting the structure of strongly-interacting matter in laboratory nuclei and in the cosmos. We present results and discuss the status of first calculations with microscopic three-nucleon interactions beyond light nuclei. This coherent effort is possible due to advances based on effective field theory and renormalization group methods in nuclear physics.Comment: 7 pages, 11 figures, talk at International Symposium on New Facet of Three-Nucleon Force (FM50), Tokyo, October, 200

I^+ states of ^<26>Mg through the (α, ^3He) reaction at 81MeV

The ^Mg (α, ^3He) ^Mg reaction leading to seven 1^+ states, proposed previously by proton scattering at 201 MeV and by the (α, ^3He) reaction at 50MeV, was measured at E_α=80.9MeV. The cross sections obtained were analyzed within the framework of the exact-finite-range distorted wave Born approximation. The spectroscopic factors for a d_ transfer to 1^+ states were compared with those predicted by sd shell model calculations. Two of the 1^+ states were found to have a simple (d_d_) structure consistent with the shell model picture. Others with too large d_ transfer strength were ascribed owing to a mixture of other nearby states with J^π values other than 1^+ in referring to a recent compilation

Formation of first star clusters under the supersonic gas flow -- I. Morphology of the massive metal-free gas cloud

We performed $42$ simulations of the first star formation with initial supersonic gas flows relative to the dark matter at the cosmic recombination era. Increasing the initial streaming velocities led to delayed halo formation and increased halo mass, enhancing the mass of the gravitationally shrinking gas cloud. For more massive gas clouds, the rate of temperature drop during contraction, in other words, the structure asymmetry, becomes more significant. When the maximum and minimum gas temperature ratios before and after contraction exceed about ten, the asymmetric structure of the gas cloud prevails, inducing fragmentation into multiple dense gas clouds. We continued our simulations until $10^5$ years after the first dense core formation to examine the final fate of the massive star-forming gas cloud. Among the $42$ models studied, we find the simultaneous formation of up to four dense gas clouds, with a total mass of about $2254\,M_\odot$. While the gas mass in the host halo increases with increasing the initial streaming velocity, the mass of the dense cores does not change significantly. The star formation efficiency decreases by more than one order of magnitude from $\epsilon_{\rm III} \sim 10^{-2}$ to $10^{-4}$ when the initial streaming velocity, normalised by the root mean square value, increases from 0 to 3.Comment: 15 pages, 16 figures, 1 table, Accepted for publication in MNRA

Measurements of Total Neutron Cross Sections of C, Fe, Pb, O, Mo, Si, Zn, Ni, Sn, Ti and W at Energies 20-60 MeV

Measurements of total neutron cross sections of C, Fe, Pb, O, Mo, Si, Zn, Ni, Sn, Ti and W were made, using white neutrons from a thick Cu target bombarded by 65- and 75-MeV protons. The cross sections were obtained in the energy range 20-60 MeV. The obtained data agree well with others in the case where other data were already existing. The present work added several new data points for Ni, Mo, Sn, Zn, Ti and W, for which the number of existing data was not enough

Attaining Complete Remission May Confer a Better Outcome after Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Acute B-cell Lymphoblastic Leukemia

Introduction : Treatment outcome of adult patients with acute B-cell lymphoblastic leukemia (ALL) is suboptimal even after an allogeneic hematopoietic stem cell transplantation (allo-HSCT). To maximize the efficacies of this treatment strategy, risk stratification is crucial. Methods : We retrospectively collected clinical data of the adult patients with allo-HSCT for ALL at a single insitiution in Japan between 2003 and 2022. Univariate and multivariate analyses were performed to identify risk factors for overall survival (OS), progression-free survival (PFS) and GVHD-free-and-relapse-free survival (GRFS) at 3 years. Results : A total of 58 patients were included with 34 females and a median age of 39. Sixty-two percent of patients harbored high-risk cytogenetic features or Philadelphia chromosome (Ph). Hematologic complete response (CR) rate was 93 ％ after a first induction, but 75.9 ％ were in CR at allo-HSCT. Blinatumomab was used in 1.7 ％ of patients. A chimeric mRNA had been detected in 4 of 26 patients at allo-HSCT. The 3-year OS, PFS and GRFS were 72.7 ％, 54.7 ％ and 46.2 ％, respectively. Pre-transplantation CR was an independent risk factor. Discussion/Conclusions : Our results imply that a better OS may potentially be achieved by improved pretransplantation CR rate with more frequent application of novel agents.Article信州医学雑誌 71(5) : 257-267, (2023)journal articl

Dual-alkylator Conditioning Regimen with Busulfan and Melphalan for Bone Marrow Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Myelofibrosis : The Results of a Retrospective Study at a Single Institution in Japan

Myelofibrosis (MF) is a myeloproliferative neoplasm associated with significant morbidity and mortality, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative approach. While the optimal conditioning regimen before allo-HSCT for MF patients remains to be determined, recent studies have suggested that a thiotepa-busulfan-containing dual-alkylator regimen, FBT regimen, may be associated with favorable outcomes. In Japan, however, thiotepa is not indicated for MF. Here we describe the results of 6 cases of MF treated with melphalan-busulfan containing dual-alkylator regimen, FBM regimen, followed by their first allo-HSCT at a single institution. Neutrophil and platelet engraftment was achieved in all patients. And a full donor chimerism was confirmed in all patients at ＋30 days after allo-HSCT. The relatively small size and short observation period of our study make it difficult to draw a definitive conclusion ; however, our results suggest that a dualalkylator regimen of FBM may be a candidate for an conditioning for allo-HSCT for MF, which should be verified with a large cohort of patients.Article信州医学雑誌 71(6) : 393-402, (2023)journal articl

Putrescine Importer PlaP Contributes to Swarming Motility and Urothelial Cell Invasion in Proteus mirabilis

Previously, we reported that the speA gene, encoding arginine decarboxylase, is required for swarming in the urinary tract pathogen Proteus mirabilis. In addition, this previous study suggested that putrescine may act as a cell-to-cell signaling molecule (Sturgill, G., and Rather, P. N. (2004) Mol. Microbiol. 51, 437-446). In this new study, PlaP, a putative putrescine importer, was characterized in P. mirabilis. In a wild-type background, a plaP null mutation resulted in a modest swarming defect and slightly decreased levels of intracellular putrescine. In a P. mirabilis speA mutant with greatly reduced levels of intracellular putrescine, plaP was required for the putrescine-dependent rescue of swarming motility. When a speA/plaP double mutant was grown in the presence of extracellular putrescine, the intracellular levels of putrescine were greatly reduced compared with the speA mutant alone, indicating that PlaP functioned as the primary putrescine importer. In urothelial cell invasion assays, a speA mutant exhibited a 50% reduction in invasion when compared with wild type, and this defect could be restored by putrescine in a PlaP-dependent manner. The putrescine analog Triamide-44 partially inhibited the uptake of putrescine by PlaP and decreased both putrescine stimulated swarming and urothelial cell invasion in a speA mutant