1 research outputs found
Physicochemical Profiling of Surfactant-Induced Membrane Dynamics in a Cell-Sized Liposome
We used a cell-sized model system, giant liposomes, to
investigate
the interaction between lipid membranes and surfactants, and the membrane
transformation during the solubilization process was captured in real
time. We found that there are four distinct dynamics in surfactant-induced
membrane deformation: an episodic increase in the membrane area prior
to pore-forming associated shrinkage (Dynamics A), fission into many
small liposomes (Dynamics B), the formation of multilamellar vesicles
and peeling (Dynamics C), and bursting (Dynamics D). Classification
of the diversity of membrane dynamics may contribute to a better understanding
of the physicochemical mechanism of membrane solubilization induced
by various surfactants