RASEFは肺癌の新たな診断マーカー及び治療標的である

Genome-wide gene expression profile analyses revealed that Ras and EF-hand domain containing (RASEF) was significantly transactivated in the majority of lung cancers. Transient expression of RASEF promoted cell growth, whereas transfection of siRNA for RASEF to lung cancer cells reduced its expression and resulted in growth suppression of the cancer cells. Immunohistochemical staining using tumor tissue microarrays consisting of 341 archived non-small cell lung cancers revealed the association of strong RASEF positivity with poor prognosis (P = 0.0034 by multivariate analysis). RASEF could bind to extracellular signal-regulated kinase (ERK) 1/2 and appeared to enhance the ERK1/2 signaling. In addition, inhibition of interaction between RASEF and ERK1/2 using cell-permeable peptide that corresponded to the ERK1/2-interacting site of RASEF protein, suppressed growth of lung cancer cells. RASEF may play important roles in lung carcinogenesis, and could be useful as a prognostic biomarker and a target for the development of new molecular therapies.広島大学(Hiroshima University)博士(医学)Philosophy in Medical Sciencedoctora

High-count-rate 3He position-sensitive detector system: NEUNET-HCR

Highly reliable 3He gas detectors are most often used in neutron scattering experiments but have disadvantages such as low count rates and low position resolutions. In this study, a 3He gas detector system called NEUNET-HCR was developed, whose count rate is approximately 10 times that of the current NEUNET system, which was developed for a high position resolution with a low count rate. NEUNET-HCR achieved a maximum count rate of 535 kcps per detector, with a loss of approximately 30%. As the NEUNET-HCR system was developed based on the NEUNET system, various improvements were required to achieve the high count rate. Further, a high count rate was achieved in the NEUNET-HCR system without significantly degrading the position resolution

High-count-rate

Highly reliable 3He gas detectors are most often used in neutron scattering experiments but have disadvantages such as low count rates and low position resolutions. In this study, a 3He gas detector system called NEUNET-HCR was developed, whose count rate is approximately 10 times that of the current NEUNET system, which was developed for a high position resolution with a low count rate. NEUNET-HCR achieved a maximum count rate of 535 kcps per detector, with a loss of approximately 30%. As the NEUNET-HCR system was developed based on the NEUNET system, various improvements were required to achieve the high count rate. Further, a high count rate was achieved in the NEUNET-HCR system without significantly degrading the position resolution