Characteristics of idiopathic membranous nephropathy (MN) patients with enhanced granular expression of thrombospondin type-1 domain-containing 7A (THSD7A) or M-type phospholipase A2 receptor (PLA2R) in the glomeruli.

<p>Characteristics of idiopathic membranous nephropathy (MN) patients with enhanced granular expression of thrombospondin type-1 domain-containing 7A (THSD7A) or M-type phospholipase A2 receptor (PLA2R) in the glomeruli.</p

Immunohistochemical analysis for thrombospondin type-1 domain-containing 7A (THSD7A) and M-type phospholipase A2 receptor (PLA2R).

<p>Immunostaining for THSD7A (a, c, e) and PLA2R (b, d, f) in patients with idiopathic membranous nephropathy (a–d) and secondary membranous nephropathy (e, f). Original magnification: ×400. Inset, enhanced granular expression of THSD7A (a) and PLA2R (d) shown at a higher magnification (arrows). Abbreviations: THSD7A, Thrombospondin type-1 domain-containing 7A; PLA2R, M-type phospholipase A2 receptor; MN, membranous nephropathy.</p

Examples of positive and negative staining for THSD7A, PLA2R, and IgG4.

<p>Positive staining for THSD7A (a, b), PLA2R (e, f), and IgG4 (i, j), and negative staining for THSD7A (c, d), PLA2R (g, h), and IgG4 (k, l) are shown.</p

Prevalence of enhanced granular expression of thrombospondin type-1 domain-containing 7A (THSD7A) and M-type phospholipase A2 receptor (PLA2R) in the glomeruli of patients with idiopathic membranous nephropathy (MN) and secondary MN.

<p>Prevalence of enhanced granular expression of thrombospondin type-1 domain-containing 7A (THSD7A) and M-type phospholipase A2 receptor (PLA2R) in the glomeruli of patients with idiopathic membranous nephropathy (MN) and secondary MN.</p

Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients - Table 1

<p>All variables are expressed as the means ± SD or the medians and interquartile range (25th to 75th percentiles).</p><p>Abbreviations: AMA, abdominal muscle area; ASFA, abdominal subcutaneous fat area; AVFA, abdominal visceral fat area; BMI, body mass index; CRP, C-reactive protein; GNRI, geriatric nutritional risk index; IL-6, interleukin-6; Kt/V _urea, amount of dialysis delivered to each patient per treatment; LDL, low-density lipoprotein; nPNA, normalized protein equivalent of nitrogen appearance; PTH, parathyroid hormone.</p><p>Patient Characteristics.</p

Association between abdominal muscle areas and 20S proteasome levels.

<p>Association between abdominal muscle areas and 20S proteasome levels.</p

Western blot analysis of 20S proteasome in 11 patients.

<p>Bands of the 20S proteasome are detected (arrow head). Laddered bands were also present under the specific bands (asterisk).</p

Multivariate-adjusted odds ratios for all-cause mortality according to the BMI groups and the tertiles of serum Cr.

<p>We applied the group with normal-weight and the middle tertile of Cr as the reference. Abbreviations are BMI: body mass index, Cr: creatinine and Ref: reference group. ^ap, ^bp and ^cp denoted p values less than 0.001, 0.01 and 0.05 respectively.</p

Patient selection.

<p>Fig 1 represented how to select and enroll the patients into analyses. Abbreviations are BMI: body mass index, ESRD: end-stage renal disease, PD: peritoneal dialysis, HD: hemodialysis and CRP: C-reactive protein.</p

Associations of BMI with morbidities according to Cr levels in male.

<p>Associations of BMI with morbidities according to Cr levels in male.</p