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Amitorines A and B, Nitrogenous Diterpene Metabolites of <i>Theonella swinhoei</i>: Isolation, Structure Elucidation, and Asymmetric Synthesis
Two new nitrogenous prenylbisabolanes
never before found in Lithistid
sponges have been isolated from <i>Theonella swinhoei</i>. These new diterpenes, named amitorine A (<b>1</b>) and amitorine
B (<b>2</b>), containing a prenylbisabolane skeleton have been
characterized by spectroscopic analyses, and the relative and absolute
configurations of <b>1</b> and <b>2</b> were determined
by asymmetric synthesis of both diastereomers via the common bicyclic
lactone <b>6</b> intermediate