Detection of Epidermal Growth Factor Receptor Mutations in Serum as a Predictor of the Response to Gefitinib in Patients with Non-Small-Cell Lung Cancer

取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1810号, 学位授与年月日 : 平成18年9月28日, 学位授与大学 : 金沢大学, 主査教授 : 中尾 眞二, 副査教授 : 金子 周一, 渡邊

THE DIGITAL WIDE BAND CHIRP PULSE GENERATOR AND PROCESSOR FOR PI-SAR2

BRIEF CONCLUSION This paper shows the digital wide band chirp pulse generator and processor for Pi-SAR2, and the history of its development at NEC. This generator and processor can generate the 150, 300 or 500MHz bandwidth chirp pulse and process the same bandwidth video signal. The offset video method is applied for this component in order to achieve small phase error, instead of I/Q video method for the conventional SAR system. Pi-SAR2 realized 0.3m resolution with the 500 MHz bandwidth by this component. After that, we had developed the experimental model of the digital wide band chirp pulse generator and processor for the airborne and spaceborne SAR in 2005. This model adopted the offset video method for the high performance, instead of the conventional I/Q video method. It had capabilities to generate the 300MHz bandwidth chirp pulse and to process video signals at 720MHz sampling rate for the input with 300MHz bandwidth. For the conventional signal generator by the I/Q video method, it is necessary to generate the In-phase(I) and Quadraturephase(Q) signals and to mix two signals using an analog I/Q modulator. The frequency of output signal from the wide band chirp generator is much higher than that of the conventional narrow one. Therefore mutual timing condition should be strictly required for the generation of two signals (I and Q) and its mixing. Otherwise the phase error of I/Q modulation would be large. On the other hand, it is not necessary to mix I/Q signals for the chirp pulse generation with the offset video method. Therefore there is no phase error of I/Q modulation in this method. This i

A Paraganglioma in a Hypertensive Patient with Unilateral Renal Hypoplasia

We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia

Helicobacter cinaedi-associated Carotid Arteritis

A 65-year-old Japanese man with bilateral carotid atherosclerosis presented with right neck pain and fever. Contrast-enhanced computed tomography suggested carotid arteritis, and carotid ultrasonography showed an unstable plaque. The patient developed a cerebral embolism, causing a transient ischemic attack. Helicobacter cinaedi was detected in blood culture, and H. cinaedi-associated carotid arteritis was diagnosed. Empirical antibiotic therapy was administered for 6 weeks. After readmission for recurrent fever, he was treated another 8 weeks. Although the relationship between H. cinaedi infection and atherosclerosis development remains unclear, the atherosclerotic changes in our patient’s carotid artery might have been attributable to H. cinaedi infection

副鼻腔転移をきたした肺腺癌の1例

金沢大学大学院医学系研究科細胞移植学講座Background. Even though the head and neck are common metastatic sites in lung cancer patients, paranasal metastases are rare. We report a patient with lung cancer who had paranasal sinus metastases. Case. A 56-year-old man with lung cancer presented with nasal hemorrhage 1.5 years after the initiation of chemotherapy. On CT, mass shadows were seen in bilateral frontal sinuses, maxillary antra, the left ethmoidal sinus, the sphenoidal sinus, and the nasal cavity. Biopsies of the lesion in the nasal cavity showed adenocarcinoma, confirming that the lesions in the paranasal sinuses were lung cancer metastases. The cranial MRI done at the time of the first admission was reviewed, and a small nodule was found in left ethmoidal sinus. Conclusion. Paranasal sinus metastases are found in a patient with NSCLC who don\u27t have symptoms related to the paranasal sites. Paranasal sites should be carefully evaluated in patients with advanced NSCLC. © 2008 The Japan Lung Cancer Society.　　　[背景]肺癌の頭頸部への転移は比較的高い頻度で認められるが、副鼻腔転移は極めて稀である。今回われわれは、経過中に副鼻腔転移を認めた症例を経験した。[症例]症例は56歳、男性。1年半にわたる肺癌治療経過中に鼻出血が出現した。頭部CTでは両側前頭洞、左側篩骨洞・上顎洞・鼻腔にかけて腫瘤性病変を認めた。生検による病理組織像は原発巣と同一の腺癌であった。初回入院時の頭部MRIをレトロスペクティブに検討したところ、左篩骨洞に腫瘤陰影があり、初診時にすでに副鼻腔転移を認めていたものと考えられた。[結論]副鼻腔転移は治療経過中に認められる報告が多いが、初診時にも無症状の副鼻腔転移を有する場合があり、慎重に診断して観察する必要がある。全文公開20101

Complication of Chronic Eosinophilic Pneumonia in an Elderly Patient with Sjögren Syndrome

An 81-year-old Japanese male with primary Sjögren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patientʼs condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patientʼs clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients

Bronchial thermoplasty for severe asthma

Despite the relatively short follow-up period in our previous study, we had reported that increased cough reflex sensitivity (CRS) may predict the efficacy of bronchial thermoplasty (BT) for treating asthma. Herein, we examined whether CRS predicts the efficacy of BT 2 years after the final BT treatment. We also investigated the influence of BT on CRS. We reviewed 10 patients 2 years after their final BT treatment. CRS, asthma-related symptoms, asthma exacerbations, and cough-related quality of life were assessed at baseline and 2 years after BT. Five patients responded positively to BT (BT responders) and their asthma control improved. No significant difference in CRS at baseline was detected between the BT responders and nonresponders. In contrast, BT responders exhibited significant improvements in CRS 2 years after BT. CRS at baseline could not predict the BT efficacy after 2 years. This is the first report demonstrating BT desensitized CRS in consecutive case series

Asthma-COPD overlap : prevalence and features

Background Asthma-COPD overlap (ACO) is a disease that shares clinical features of both asthma and COPD. The purpose of this study is to investigate the prevalence and clinical features of ACO. Methods We retrospectively reviewed data for 170 patients with persistent airflow limitation and diagnosed them according to “The Japanese Respiratory Society Guidelines for the Management of ACO 2018”. Results Of the 170 patients, 111 were diagnosed as follows : COPD (74 patients, 66.6%), ACO (34 patients, 30.6%), and asthma (3 patients, 2.8%). There was no significant difference in clinical features between ACO and COPD patients. The following pulmonary function tests were significantly lower in ACO than in COPD patients : forced expiratory volume in 1 second/forced vital capacity, peak expiratory flow, maximal mid-expiratory flow, and the maximum expiratory flow at 50% and 75%. The following respiratory impedance parameters were significantly higher in ACO than in COPD patients : respiratory resistance (Rrs) at 5 Hz (R5), Rrsat 20 Hz (R20), R5-R20, and low-frequency reactance area. Conclusions About 30% of patients with persistent airflow limitation were diagnosed with ACO. ACO patients had lower lung function and higher respiratory impedance compared with COPD patients

Antitumor effects of inductive hyperthermia using magnetic ferucarbotran nanoparticles on human lung cancer xenografts in nude mice

Background: The effects of inductive hyperthermia on lung cancer have yet to be fully investigated. Magnetic nanoparticles used in inductive hyperthermia are made-to-order and expensive. This study was performed to investigate the use of ferucarbotran in inductive hyperthermia and to clarify whether inductive hyperthermia using ferucarbotran promotes antitumor effects in vivo using a lung cancer cell line. Methods: We injected A549 cells subcutaneously into the right thighs of BALB/c nu/nu nude mice. Forty mice with A549 xenografts were then classified into three groups. Group 1 was the control group. All mice in groups 2 and 3 had ferucarbotran injected into their tumors, and mice in group 3 were then subjected to alternating magnetic field irradiation. We evaluated tumor temperature during the hyperthermic procedure, the time course of tumor growth, histologic findings in tumors after hyperthermic treatment, and adverse events. Results: Intratumor temperature rose rapidly and was maintained at 43°C-45°C for 20 minutes in an alternating magnetic field. Tumor volumes in groups 1 and 2 increased exponentially, but tumor growth in group 3 was significantly suppressed. No severe adverse events were observed. Histologic findings for the tumors in group 3 revealed mainly necrosis. Conclusion: Inductive hyperthermia using ferucarbotran is a beneficial and promising approach in the treatment of lung cancer. Ferucarbotran is a novel tool for further development of inductive hyperthermia. © 2013 Araya et al, publisher and licensee Dove Medical Press Ltd