919 research outputs found
Rate constants and Arrhenius parameters for the reactions of OH radicals and Cl atoms with CF3CH2OCHF2, CF3CHClOCHF2 and CF3CH2OCClF2, using the discharge-flow/resonance fluorescence method
Rate constants have been determined for the reactions of OH radicals and Cl atoms with the three partially halogenated methyl-ethyl ethers, CFCHOCHF, CFCHClOCHF and CFCHOCClF, using discharge-flow techniques to generate the OH radicals and the Cl atoms and resonance fluorescence to observe changes in their relative concentrations in the presence of added ether. For each combination of radical and ether, experiments were carried out at three temperatures between 292 and 410 K, yielding the following Arrhenius expressions for the rate constants within this range of temperature:
OH + CFCHOCHF: = (2.00.8) 10 exp( – 2110 150 K / T) cm molecule s
OH + CFCHClOCHF: = (4.5 1.3) 10 exp( – 940 100 K / T) cm molecule s
OH + CFCHOCClF: = (1.6 0.6) 10 exp( – 1100 125 K / T) cm molecule s
Cl + CFCHOCHF: = (6.1 1.4) 10 exp( – 1830 90 K / T) cm molecule s
Cl + CFCHClOCHF: = (7.8 2.6) 10 exp( – 2980 130 K / T) cm molecule s
Cl + CFCHOCClF: = (2.2 0.2) 10 exp( – 2700 40 K / T) cm molecule s
The results are compared with those obtained previously for the same and related reactions of OH radicals and Cl atoms, and the atmospheric implications of the results are considered briefly
Roles of the Bloom's syndrome helicase in the maintenance of genome stability
The RecQ family of DNA helicases is highly conserved in evolution from bacteria to humans. Of the five known human RecQ family members, three (BLM, WRN and RECQ4, which cause Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome respectively) are mutated in distinct clinical disorders associated with cancer predisposition and/or premature aging. BLM forms part of a multienzyme complex including topoisomerase IIIalpha, replication protein A and a newly identified factor called BLAP75. Together, these proteins play a role in the resolution of DNA structures that arise during the process of homologous recombination repair. In the absence of BLM, cells show genomic instability and a high incidence of sister-chromatid exchanges. In addition to a DNA structure-specific helicase activity, BLM also catalyses Holliday-junction branch migration and the annealing of complementary single-stranded DNA molecules
Aid and the Control of Tuberculosis in Papua New Guinea: Is Australia's Assistance Cost-Effective?
Australia supports the control of tuberculosis in Papua New Guinea for reasons of aid effectiveness and a desire to decrease the chance of importing tuberculosis to Australia. This paper analyses the case for this support using both cost-utility and cost-benefit analysis. We reach three conclusions. First, Australia directly benefits from its investment in controlling tuberculosis in Papua New Guinea, with a cost of US 22 million. Second, the longer and more extensive the basic directly observed short course therapy, or basic DOTS, to control tuberculosis, the higher are the returns for Australia. Finally, in addition to surpassing all commonly used benchmarks for being a cost-effective investment for Australia, a basic DOTS expansion also generates a health benefit for Papua New Guinea that compares well as one of the 'ten best health buys' in developing countries. � 2014 The Authors
A Metapopulation Model of Tuberculosis Transmission with a Case Study from High to Low Burden Areas
Tuberculosis (TB) is a growing problem worldwide, especially with the emergence and high prevalence of multidrug-resistant strains. We develop a metapopulation model for TB spread, which is particularly suited to investigating transmission between areas of high and low prevalence. A case study of cross-border transmission in the Torres Strait region of Australia and Papua New Guinea (PNG) is considered and a sensitivity analysis is conducted. We find that only 6 of the 50 parameters analysed are important to the cumulative number of clinically active TB patients in the entire region. Of these, only the detection rate in PNG is found to be an important intervention parameter. We therefore give insight into the extent the area with the high burden of TB (PNG in the case study) is dominating the TB dynamics of the entire region. Furthermore, the sensitivity analysis results give insight into the data that most important to collect and refine, which is found to be data relating to the PNG parameters
A Multiscale Mathematical Model of Plasmodium Vivax Transmission
Malaria is caused by Plasmodium parasites which are transmitted to humans by the bite of an infected Anopheles mosquito. Plasmodium vivax is distinct from other malaria species in its ability to remain dormant in the liver (as hypnozoites) and activate later to cause further infections (referred to as relapses). Mathematical models to describe the transmission dynamics of P. vivax have been developed, but most of them fail to capture realistic dynamics of hypnozoites. Models that do capture the complexity tend to involve many governing equations, making them difficult to extend to incorporate other important factors for P. vivax, such as treatment status, age and pregnancy. In this paper, we have developed a multiscale model (a system of integro-differential equations) that involves a minimal set of equations at the population scale, with an embedded within-host model that can capture the dynamics of the hypnozoite reservoir.
In this way, we can gain key insights into dynamics of P. vivax transmission with a minimum number of equations at the population scale, making this framework readily scalable to incorporate more complexity. We performed a sensitivity analysis of our multiscale model over key parameters and found that prevalence of P. vivax blood-stage infection increases with both bite rate and number of mosquitoes but decreases with hypnozoite death rate. Since our mathematical model captures the complex dynamics of P. vivax and the hypnozoite reservoir, it has the potential to become a key tool to inform elimination strategies for P. vivax
Estimating the Distribution of Japanese Encephalitis Vectors in Australia Using Ecological Niche Modelling
Recent Japanese encephalitis virus (JEV) outbreaks in southeastern Australia have sparked interest into epidemiological factors surrounding the virus’ novel emergence in this region. Here, the geographic distribution of mosquito species known to be competent JEV vectors in the country was estimated by combining known mosquito occurrences and ecological drivers of distribution to reveal insights into communities at highest risk of infectious disease transmission. Species distribution models predicted that Culex annulirostris and Culex sitiens presence was mostly likely along Australia’s eastern and northern coastline, while Culex quinquefasciatus presence was estimated to be most likely near inland regions of southern Australia as well as coastal regions of Western Australia. While Culex annulirostris is considered the dominant JEV vector in Australia, our ecological niche models emphasise the need for further entomological surveillance and JEV research within Australia
The Properties of Poor Groups of Galaxies: III. The Galaxy Luminosity Function
We obtain R-band photometry for galaxies in six nearby poor groups for which
we have spectroscopic data, including 328 new galaxy velocities. For the five
groups with luminous X-ray halos, the composite group galaxy luminosity
function (GLF) is fit adequately by a Schechter function with Mstar = -21.6 +/-
0.4 + 5log h and alpha = -1.3 +/- 0.1. We also find that (1) the ratio of
dwarfs to giants is significantly larger for the five groups with luminous
X-ray halos than for the one marginally X-ray detected group, (2) the composite
GLF for the luminous X-ray groups is consistent in shape with that for rich
clusters, (3) the composite group GLF rises more steeply at the faint end than
that of the field, (4) the shape difference between the field and composite
group GLF's results mostly from the population of non-emission line galaxies,
whose dwarf-to-giant ratio is larger in the denser group environment than in
the field, and (5) the non-emission line dwarfs are more concentrated about the
group center than the non-emission line giants. This last result indicates that
the dwarfs and giants occupy different orbits (i.e., have not mixed completely)
and suggests that the populations formed at a different times. Our results show
that the shape of the GLF varies with environment and that this variation is
due primarily to an increase in the dwarf-to-giant ratio of quiescent galaxies
in higher density regions, at least up to the densities characteristic of X-ray
luminous poor groups. This behavior suggests that, in some environments, dwarfs
are more biased than giants with respect to dark matter. This trend conflicts
with the prediction of standard biased galaxy formation models. (Abridged)Comment: 36 pages, AASLaTeX with 8 figures. Table 1 also available at
http://atropos.as.arizona.edu/aiz/papers/all_grp_lf_ascii.dat.final . To
appear in Ap
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