Assert Yourself! evaluating the performance of an HIV prevention intervention

Duration: November 1996 - June 2012 CHAPS is a collaborative programme of HIV health promotion for gay men and bisexual men living in England. It is co-ordinated by Terrence Higgins Trust on behalf of a range of project partners, including Sigma Research. The CHAPS programme includes a national HIV prevention mass media campaign each year, which usually include adverts, leaflets, magazines and other small media. Data from the Gay Men's Sex Survey is used to inform the targets and aims of these interventions and their development is supported by pre-testing with the target audience via focus groups. After the launch of the interventions, Sigma generates performance data about their performance. This includes annual coverage surveys where gay men and bisexual men are asked if they recognise the adverts, magazines and leaflets. This data is used to look in greater detail at the targeting of the campaigns. Using data from these surveys, we make recommendations on the most efficient media spend for advertising. In addition, we undertake end-user focus groups in which gay men and bisexual men are asked about their opinions, reactions and responses to the campaigns. This work follows on from the pre-testing groups, and looks at the relevance of the campaigns in situ. We also evaluate the sector development or facilitation interventions, undertaken within the CHAPS partnership including training events, Symposiums and the annual CHAPS conference. Three CHAPS summary final evaluation reports are available alongside many of the interim reports of CHAPS evaluation activities on which they are based. Click here for more details. CHAPS evaluation is funded by Terrence Higgins Trust as part of CHAPS, a national HIV prevention initiative funded by the Department of Health

Eliminating the Coriols Effect in Liquid Mirrors

If uncorrected, the Coriolis force due to the rotation of the Earth causes significant aberration of images produced by large liquid-mirror telescopes. We show that this problem can be eliminated by a fixed compensating tilt of the liquid-mirror rotation axis. The required tilt angle, which is a function of latitude and mirror rotation rate, is of order 10 arcsec for current telescopes. This result removes the last fundamental obstacle to achieving diffraction-limited performance with large liquid mirrors.Comment: 8 pages 1 figure, submitted to PAS

Sexually transmitted infection as a risk factor for homosexual HIV transmission: a systematic review of epidemiological studies

Existing reviews suggest some sexually transmitted infections (STIs) are risk factors in heterosexual HIV transmission. This may not be so in homosexual HIV transmission, about which reviews make no specific conclusions. This paper reviews published studies which report on the relative risk of STIs in HIV seroconversion in homosexually-active men in order to examine this matter. Papers obtained via various searches were judged adequate if they were prospective cohort or cohort-nested case-control studies; used HIV seroconversion as the outcome; assessed STI exposure objectively; and controlled for potential confounding from age and sexual behaviour. Sixteen papers were obtained, of these 3 were judged adequate. Adequate papers reported little association. Inadequate papers were more likely to report association. Evidence from adequate studies does not suggest STIs are risk factors in homosexual HIV transmission. Some caution is needed in interpreting the results because of the paucity of adequate studies

Cosmology at Low Redshifts

It is argued that it is far more cost effective to carry out some projects with medium-sized dedicated zenith telescopes rather than large steerable telescopes, freeing the later to carry out projects that truly need them. I show that the large number of objects observed with a surveying 4-m zenith telescope allows one to carry out cosmological projects at low redshifts. Examining two case studies, I show first that a variability survey would obtain light curves for several thousands of type Ia supernovae per year up to z=1 and easily discriminate among competing cosmological models. Finally, I discuss a second case study, consisting of a spectrophotometric survey carried out with interference filters, showing its power to discriminate among cosmological models and to study the large-scale distribution of galaxies in the Universe.Comment: PDF file 294KB Astronomy & Astrophysics 2003, In Pres

Vital Statistics Ireland: findings from the All-Ireland Gay Men’s Sex Survey 2000

Duration: March 2000 - September 2010 Sigma Research has been working with Ireland's Gay Health Network (GHN) since 2000. GHN is an umbrella organisation working towards gay men's health and HIV prevention. GHN instigated a community-based, self-completion survey to take place across The Republic of Ireland and Northern Ireland during the summer of 2000 and commissioned Sigma Research to work with them. This large-scale community research project was the third such survey among gay men in Ireland, and built on previous findings. After the development and piloting of the survey, recruitment commenced at Dublin Pride in June 2000 and continued throughout the summer at similar events in Belfast, Derry, Galway, Limerick and Waterford. Recruitment in bars and clubs took place in Dublin and Cork, and social groups in more rural area were sent copies of the questionnaire and a request to distribute them to their members. 1,290 questionnaires were returned by gay men (81%), bisexual men (11%) and other homosexually active men living in Ireland. 19% of all respondents lived in Northern Ireland. A full survey report, including implications for HIV prevention planning is available to download. Since 2003 Gay Health Network members - particularly The Gay Men's Health Service (Health Services Executive) and the Rainbow Project, Northern Ireland - have collaborated with our online UK version of the Gay Men’s Sex Survey (Vital Statistics) by promoting it to men in Ireland via community websites and postcards distributed on the gay scene. Real Lives, a summary report covering the main GMSS 2003 and 2004 data for men resident on the island of Ireland, was published in June 2006 and is available to download. It was published with The Gay Men's Health Service, Health Services Executive and the Rainbow Project. Real Lives II, a summary report covering the main GMSS 2005 and 2006 data for men resident on the island of Ireland, was published in June 2009 and is available to download. It was published with The Gay Men's Health Service, Health Services Executive and the Rainbow Rpoject. A summary report for Irish-resident men taking part in GMSS 2007 and 2008 will be published in June 2010

London counts: HIV prevention needs and interventions among gay men in 16 London Health Authorities

Duration: December 1998 - February 2001 Commissioned by the sixteen London Health Authority Commissioners, the Link Evaluation included work by both Sigma Research, and the Thomas Coram Research Unit at the Institute of Education, University of London. The LINK Evaluation aimed to identify whether and why HIV prevention interventions are successful for Gay men in London. Objectives of the study included: Identification and agreement of health promotion aims with all commissioners and prevention agencies within the partnership. Collation of data and information from related studies of Gay men’s HIV health promotion needs and comparable programme evaluations. Annual health promotion ‘Activity Map' which described all HIV health promotion interventions planned for London for each year. Annual ‘Needs Map' report concerning the needs of Gay men in London. Examination of the collective impact of the activities of collaborating agencies on the population of Gay men in London. Four examinations of the performance and impact of individual interventions or groups of interventions sharing methodological characteristics. The LINK Evaluation was a rolling programme of utilisation-focussed outcome evaluation and needs assessment of HIV health promotion intended to reduce the incidence of HIV through sex between men resident in London. A range of research methods were employed including: self-completion questionnaires, face-to-face interviews and workshops. Sample sizes varied according to the specific programme activity: 1500 men were recruited to a rolling cohort to examine their changing HIV health promotion needs, a further 200 were recruited for more in-depth needs and experiences mapping and over 100 agencies were recruited to examine the health promotion activity being delivered in London. Findings were useful in answering questions such as: i) What needs required addressing - the Needs Map was used to prioritise health promotion aims and population groups, and to guide intervention selection and the development of services within a broad programme planning approach. ii) Which interventions best address identified need - findings regarding the performance and impact of specific interventions were used in order to maximise cost-efficiency. iii) Where interventions were being implemented, and where they were not - the Activity Maps were used to gauge intended impact, identify gaps in provision and to facilitate collaborative planning. iv) Whether the programme of HIV health promotion was working - the programme evaluation findings were used to identify the overall impact of a strategic and collaborative London-wide programme and to inform future developments. v) Why the programme of HIV health promotion was working - the in-depth data from those exposed to interventions was used to identify the key features of a strategic programme which contribute to change. Two reports are available: London counts: HIV prevention needs and interventions among gay and bisexual men in 16 London Health Authorities and HIV health promotion activity map for Greater London 1999-2000

Roles of the Bloom's syndrome helicase in the maintenance of genome stability

The RecQ family of DNA helicases is highly conserved in evolution from bacteria to humans. Of the five known human RecQ family members, three (BLM, WRN and RECQ4, which cause Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome respectively) are mutated in distinct clinical disorders associated with cancer predisposition and/or premature aging. BLM forms part of a multienzyme complex including topoisomerase IIIalpha, replication protein A and a newly identified factor called BLAP75. Together, these proteins play a role in the resolution of DNA structures that arise during the process of homologous recombination repair. In the absence of BLM, cells show genomic instability and a high incidence of sister-chromatid exchanges. In addition to a DNA structure-specific helicase activity, BLM also catalyses Holliday-junction branch migration and the annealing of complementary single-stranded DNA molecules

Real Lives: findings from the All-Ireland Gay Men’s Sex Surveys, 2003 and 2004

Duration: March 2000 - September 2010 Sigma Research has been working with Ireland's Gay Health Network (GHN) since 2000. GHN is an umbrella organisation working towards gay men's health and HIV prevention. GHN instigated a community-based, self-completion survey to take place across The Republic of Ireland and Northern Ireland during the summer of 2000 and commissioned Sigma Research to work with them. This large-scale community research project was the third such survey among gay men in Ireland, and built on previous findings. After the development and piloting of the survey, recruitment commenced at Dublin Pride in June 2000 and continued throughout the summer at similar events in Belfast, Derry, Galway, Limerick and Waterford. Recruitment in bars and clubs took place in Dublin and Cork, and social groups in more rural area were sent copies of the questionnaire and a request to distribute them to their members. 1,290 questionnaires were returned by gay men (81%), bisexual men (11%) and other homosexually active men living in Ireland. 19% of all respondents lived in Northern Ireland. A full survey report, including implications for HIV prevention planning is available to download. Since 2003 Gay Health Network members - particularly The Gay Men's Health Service (Health Services Executive) and the Rainbow Project, Northern Ireland - have collaborated with our online UK version of the Gay Men’s Sex Survey (Vital Statistics) by promoting it to men in Ireland via community websites and postcards distributed on the gay scene

A New Ultra-dense Group of Obscured Emission-Line Galaxies

We present the discovery of an isolated compact group of galaxies that is extremely dense (median projected galaxy separation: 6.9 kpc), has a very low velocity dispersion ($\sigma_{\rm 2D}$ = 67 km s$^{-1}$), and where all observed members show emission lines and are morphologically disturbed. These properties, together with the lack of spirals and the presence of a prominent tidal tail make this group one of the most evolved compact groups.Comment: 15 pages,LaTeX, 2figures. A Postscript figure with spectra is available at ftp://astro.uibk.ac.at/pub/weinberger/ . Accepted for publication in ApJ Letter