2 research outputs found
Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone
Although
polyetheretherketone (PEEK) has been considered as a potential orthopedic and dental application
material due to its similar elastic modulus as bones, inferior osseointegration
and bacteriostasis of PEEK hampers its clinical application. In this
work, fluorinated PEEK was constructed via plasma immersion ion implantation
(PIII) followed by hydrofluoric acid treatment to ameliorate the osseointegration
and antibacterial properties of PEEK. The surface microstructure,
composition, and hydrophilicity of all samples were investigated.
Rat bone mesenchymal stem cells (rBMSCs) were cultured on their surfaces
to estimate bioactivity. The fluorinated PEEK can enhance the cell
adhesion, cell spreading, proliferation, and alkaline phosphatase
(ALP) activity compared to pristine PEEK. Furthermore, the fluorinated
PEEK surface exhibits good bacteriostatic effect against Porphyromonas gingivalis, which is one of the major
periodontal pathogens. In summary, we provide an effective route to
introduce fluorine and the results reveal that the fluorinated PEEK
can enhance the osseointegration and bacteriostasis, which provides
a potential candidate for dental implants
Image1_Association of methylenetetrahydrofolate reductase (MTHFR) rs1801133 (677C>T) gene polymorphism with ischemic stroke risk in different populations: An updated meta-analysis.TIF
Background: Recently, increasing evidence has implicated methylenetetrahydrofolate reductase (MTHFR) gene mutation as a risk factor for ischemic stroke (IS) in the general population. However, studies have been inconclusive and lack evidence on specific populations. We aim to determine whether the rs1801133 (NC_000001.11 (MTHFR):g. 677C>T (p.Ala222Val) variant, we termed as MTHFR rs1801133 (677 C>T), is linked to an increased risk of IS in different age groups and ancestry groups.Methods: The literature relevant to our study was found by searching the PubMed, Cochrane Library, Web of Science, EMBASE, and CNKI databases. A random effect model analysis was used to calculate the pooled odds ratio (OR) and 95% confidence interval (CI) to evaluate any possible association. We conducted a subgroup analysis based on the age and ancestry groups of the included populations.Results: As of March 2022, 1,925 citations had been identified in electronic databases, of which 96 studies involving 34,814 subjects met our eligibility criteria. A strong link was found between IS and the MTHFR gene rs1801133 (677C>T) polymorphism in all genetic models [dominant genetic model (OR = 1.47; 95%CI = 1.33–1.61; p T) variant may increase the risk of IS in Asian, Hispanic, or Latin population, middle-aged, and elderly populations (p Conclusion: Our results implied that mutation of the T allele of MTHFR rs1801133 (677C>T) could be a risk factor for IS. A significant association was found among Asian, Hispanic, or Latin population, middle-aged, and elderly people.</p