April_2018_ASR_media_abstracts_Liu – Supplemental material for Social and Genetic Pathways in Multigenerational Transmission of Educational Attainment

<p>Supplemental material, April_2018_ASR_media_abstracts_Liu for Social and Genetic Pathways in Multigenerational Transmission of Educational Attainment by Hexuan Liu in American Sociological Review</p

FHS data – the empirical density distribution of couple correlation for married-couples (N = 989), opposite-sex random pairs from permuted individuals in FHS (N = 200,000), opposite-sex random pairs from permuted individuals among married couples (N = 246,870), parent-child pairs (N = 6,958), and full sibling pairs (N = 5,713), with each mixed-model regression estimating a within-a-single-pair correlation “averaged” over 287,294 SNPs.

<p>FHS data – the empirical density distribution of couple correlation for married-couples (N = 989), opposite-sex random pairs from permuted individuals in FHS (N = 200,000), opposite-sex random pairs from permuted individuals among married couples (N = 246,870), parent-child pairs (N = 6,958), and full sibling pairs (N = 5,713), with each mixed-model regression estimating a within-a-single-pair correlation “averaged” over 287,294 SNPs.</p

HRS data – the empirical density distribution of the “positive” and “negative” couple correlation for married couples (N = 3,474), opposite-sex random pairs from permuted individuals in the HRS (N = 200,000), and opposite-sex random pairs from permuted individuals among married couples (N = 200,000), with each mixed-model regression estimating the within a single-pair correlation “averaged” over about one half of the 66,526 SNPs.

<p>HRS data – the empirical density distribution of the “positive” and “negative” couple correlation for married couples (N = 3,474), opposite-sex random pairs from permuted individuals in the HRS (N = 200,000), and opposite-sex random pairs from permuted individuals among married couples (N = 200,000), with each mixed-model regression estimating the within a single-pair correlation “averaged” over about one half of the 66,526 SNPs.</p

FHS data – the empirical density distribution of married-couple correlation over the 287,295 SNPs; (1) married couples (N = 989) without control for population admixture, (2) married couples (N = 989) with control for population admixture, and (3) opposite-sex random pairs from permuted individuals in FHS (N = 200,000).

<p>Panels (2) and (3) are the same as Panels (1) and (2) in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112322#pone-0112322-g002" target="_blank">Figure 2</a> and enlarged.</p

FHS data – the correlation of height (standardized within each sex) for married couples (N of couples = 989), opposite-sex random pairs from permuted individuals in FHS (N = 200,000), opposite-sex parent-child pairs (N = 3,447), same-sex parent-child pairs (N = 3,511), opposite-sex full sibling pairs (N = 2,815), and same-sex full sibling pairs (N = 2,898).

<p>FHS data – the correlation of height (standardized within each sex) for married couples (N of couples = 989), opposite-sex random pairs from permuted individuals in FHS (N = 200,000), opposite-sex parent-child pairs (N = 3,447), same-sex parent-child pairs (N = 3,511), opposite-sex full sibling pairs (N = 2,815), and same-sex full sibling pairs (N = 2,898).</p

FHS data – genome-wide SNP-specific correlation for each of the 287,294 SNPs in 6,958 parent-child pairs.

<p>Both same-sex and opposite-sex parent-child pairs are included. The correlation was estimated using the mixed models with AR(1) covariance structure, controlling for population admixture.</p

FHS and HRS data – Two permutation tests for married-couple correlations within “negative” and “positive” SNPs: (1) permuted individuals in 989 (FHS) and 3,474 (HRS) married couples, respectively, and (2) permuted all individuals in FHS.

<p>FHS and HRS data – Two permutation tests for married-couple correlations within “negative” and “positive” SNPs: (1) permuted individuals in 989 (FHS) and 3,474 (HRS) married couples, respectively, and (2) permuted all individuals in FHS.</p

The QQ plot of observed Z-scores vs. expected Z-scores.

<p>The plot on the left side includes all 287,294 SNPs while the one on the right side excludes 8 SNPs with p-values smaller than 5×10⁻⁸.</p

Genomic Assortative Mating in Marriages in the United States - Figure 7

<p>Panel 1: FHS data – genome-wide SNP-specific correlation for each of the 287,294 SNPs in 989 married couples. Panel 2: HRS data – genome-wide SNP-specific correlation for each of the 66,526 SNPs in 3,474 married couples (these 66,525 SNPs also available in FHS). The correlation was estimated using the mixed models with AR(1) covariance structure, controlling for population admixture.</p

FHS data – the significance tests of SNP-specific correlations: the within-pair correlation of married couples against randomly-paired pairs.

<p>The tests for the 287,294 SNPs are shown in a Manhattan plot. The larger dots representing individual SNPs above the blue line indicate statistical significance at p<5×10⁻⁸.</p