1 research outputs found
Engineering of a Nanosized Biocatalyst for Combined Tumor Starvation and Low-Temperature Photothermal Therapy
Tumor
hypoxia is one of the major challenges for the treatment
of tumors, as it may negatively affect the efficacy of various anticancer
modalities. In this study, a tumor-targeted redox-responsive composite
biocatalyst is designed and fabricated, which may combine tumor starvation
therapy and low-temperature photothermal therapy for the treatment
of oxygen-deprived tumors. The nanosystem was prepared by loading
porous hollow Prussian Blue nanoparticles (PHPBNs) with glucose oxidase
(GOx) and then coating their surface with hyaluronic acid (HA) via
redox-cleavable linkage, therefore allowing the nanocarrier to bind
specifically with CD44-overexpressing tumor cells while also exerting
control over the cargo release profile. The nanocarriers are designed
to enhance the efficacy of the hypoxia-suppressed GOx-mediated starvation
therapy by catalyzing the decomposition of intratumoral hydroperoxide
into oxygen with PHPBNs, and the enhanced glucose depletion by the
two complementary biocatalysts may consequently suppress the expression
of heat shock proteins (HSPs) after photothermal treatment to reduce
their resistance to the PHPBN-mediated low-temperature photothermal
therapies