Constraints on the Persistent Radio Source Associated with FRB 20190520B Using the European VLBI Network

We present very long baseline interferometry (VLBI) observations of a continuum radio source potentially associated with the fast radio burst source FRB 20190520B. Using the European VLBI network, we find the source to be compact on VLBI scales with an angular size of <2.3 mas (3σ). This corresponds to a transverse physical size of <9 pc (at the z = 0.241 redshift of the host galaxy), confirming it to be as fast radio burst (FRB) persistent radio source (PRS) like that associated with the first-known repeater FRB 20121102A. The PRS has a flux density of 201 ± 34 μJy at 1.7 GHz and a spectral radio luminosity of L1.7 GHz = (3.0 ± 0.5) × 1029 erg s−1 Hz−1 (also similar to the FRB 20121102A PRS). Compared to previous lower-resolution observations, we find that no flux is resolved out on milliarcsecond scales. We have refined the PRS position, improving its precision by an order of magnitude compared to previous results. We also report the detection of the FRB 20190520B burst at 1.4 GHz and find the burst position to be consistent with the PRS position, at ≲20 mas. This strongly supports their direct physical association and the hypothesis that a single central engine powers both the bursts and the PRS. We discuss the model of a magnetar in a wind nebula and present an allowed parameter space for its age and the radius of the putative nebula powering the observed PRS emission. Alternatively, we find that an accretion-powered hypernebula model also fits our observational constraints

Mitochondria are required for pro-ageing features of the senescent phenotype

Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both functions are dependent on the development of the senescent phenotype, which involves an overproduction of pro‐inflammatory and pro‐oxidant signals. However, the exact mechanisms regulating these phenotypes remain poorly understood. Here, we show the critical role of mitochondria in cellular senescence. In multiple models of senescence, absence of mitochondria reduced a spectrum of senescence effectors and phenotypes while preserving ATP production via enhanced glycolysis. Global transcriptomic analysis by RNA sequencing revealed that a vast number of senescent‐associated changes are dependent on mitochondria, particularly the pro‐inflammatory phenotype. Mechanistically, we show that the ATM, Akt and mTORC1 phosphorylation cascade integrates signals from the DNA damage response (DDR) towards PGC‐1β‐dependent mitochondrial biogenesis, contributing to a ROS‐mediated activation of the DDR and cell cycle arrest. Finally, we demonstrate that the reduction in mitochondrial content in vivo, by either mTORC1 inhibition or PGC‐1β deletion, prevents senescence in the ageing mouse liver. Our results suggest that mitochondria are a candidate target for interventions to reduce the deleterious impact of senescence in ageing tissues

The Similarity Hypothesis in General Relativity

Self-similar models are important in general relativity and other fundamental theories. In this paper we shall discuss the ``similarity hypothesis'', which asserts that under a variety of physical circumstances solutions of these theories will naturally evolve to a self-similar form. We will find there is good evidence for this in the context of both spatially homogenous and inhomogeneous cosmological models, although in some cases the self-similar model is only an intermediate attractor. There are also a wide variety of situations, including critical pheneomena, in which spherically symmetric models tend towards self-similarity. However, this does not happen in all cases and it is it is important to understand the prerequisites for the conjecture.Comment: to be submitted to Gen. Rel. Gra

Exact Hypersurface-Homogeneous Solutions in Cosmology and Astrophysics

A framework is introduced which explains the existence and similarities of most exact solutions of the Einstein equations with a wide range of sources for the class of hypersurface-homogeneous spacetimes which admit a Hamiltonian formulation. This class includes the spatially homogeneous cosmological models and the astrophysically interesting static spherically symmetric models as well as the stationary cylindrically symmetric models. The framework involves methods for finding and exploiting hidden symmetries and invariant submanifolds of the Hamiltonian formulation of the field equations. It unifies, simplifies and extends most known work on hypersurface-homogeneous exact solutions. It is shown that the same framework is also relevant to gravitational theories with a similar structure, like Brans-Dicke or higher-dimensional theories.Comment: 41 pages, REVTEX/LaTeX 2.09 file (don't use LaTeX2e !!!) Accepted for publication in Phys. Rev.

Observers and Locality in Everett Quantum Field Theory

A model for measurement in collapse-free nonrelativistic fermionic quantum field theory is presented. In addition to local propagation and effectively-local interactions, the model incorporates explicit representations of localized observers, thus extending an earlier model of entanglement generation in Everett quantum field theory [M. A. Rubin, Found. Phys. 32, 1495-1523 (2002)]. Transformations of the field operators from the Heisenberg picture to the Deutsch-Hayden picture, involving fictitious auxiliary fields, establish the locality of the model. The model is applied to manifestly-local calculations of the results of measurements, using a type of sudden approximation and in the limit of massive systems in narrow-wavepacket states. Detection of the presence of a spin-1/2 system in a given spin state by a freely-moving two-state observer illustrates the features of the model and the nonperturbative computational methodology. With the help of perturbation theory the model is applied to a calculation of the quintessential "nonlocal" quantum phenomenon, spin correlations in the Einstein-Podolsky-Rosen-Bohm experiment.Comment: Some changes to introduction and discussion sections, typos corrected, conclusions unchanged. To appear in Foundations of Physic