12 research outputs found
Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus.
Get PDFDespite showing promise in preclinical models, anti-Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not been studied to formally test whether a cellular-only response can protect against infection. We demonstrate that nasal vaccination with targeted nanoparticles loaded with Staphylococcus aureus antigen protects against acute systemic S. aureus infection in the absence of any antigen-specific antibodies. These findings can help inform future developments in staphylococcal vaccine development and studies into the requirements for protective immunity against S. aureus
Multifunctional PLGA-Based Nanoparticles Encapsulating Simultaneously Hydrophilic Antigen and Hydrophobic Immunomodulator for Mucosal Immunization
No full textCytogenetic and oxidative alterations after exposure of cultured human whole blood cells to lithium metaborate dehydrate
No full textPreparation and Characterization of an Oral Vaccine Formulation Using Electrosprayed Chitosan Microparticles
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The in vitro protective effect of salicylic acid against paclitaxel and cisplatin-induced neurotoxicity
No full textThe carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response
No full textCarvacrol modulates oxidative stress and decreases cell injury in pancreas of rats with acute pancreatitis
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