555 research outputs found
Finding Success in Elementary Science Across Socioeconomic Boundaries
Elementary science education provides a platform for intellectual development, building a foundation of scientific literacy and a first entry point into interest in Science, Technology, Engineering, and Mathematics (STEM) fields. A significant body of research on elementary science education clearly defines what high-quality science education should look like at the elementary level. However, there is little understood about how to implement high-quality science instruction effectively within a school system. Prior research indicates that this problem is further compounded in low socioeconomic elementary schools by a lack of resources, time, and high teacher mobility. I used descriptive research to identify the presence of the key elements to elementary science reform within Idaho public schools that demonstrated consistent high science achievement. Survey responses were collected from principals and teachers from both low and high socioeconomic schools. The results of this study provide insight into how Idaho is currently defining high achievement in elementary science education and the value that Idaho schools are placing on science instruction at the elementary level. The results of this study also suggest a road map for where Idaho needs to focus efforts to achieve high-quality science achievement at the elementary level
A Journey Toward Mastery Teaching: STEM Faculty Engagement in a Year-Long Faculty Learning Community
As part of an institutional focus on STEM student success, a group of STEM faculty participated in a year-long faculty learning community (FLC) to explore and adopt research-based best practice in their teaching. The authors assessed the effectiveness of the FLC in influencing faculty perceptions about teaching and increasing their use of best teaching practices. Their research design used pre- and post-analysis of participants\u27 teaching logs, classroom observations, and a survey instrument that probed attitudes toward teaching and learning. Data analysis shows that the sustained support provided by the FLC increased faculty knowledge of best teaching practices and catalyzed faculty to try new pedagogical and assessment approaches. However, over the year of the FLC experience, only small shifts were observed in faculty perceptions and practice, as measured by a survey and a descriptive observation protocol, respectively. Results suggest the experience primarily supported modest faculty exploration of new strategies
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Effects of c-axis Josephson coupling on dissipation, flux dynamics and the mechanism of high-T{sub c} superconductivity
Measurements of the c-axis transport in highly anisotropic HTS materials strongly indicate that Josephson coupling is involved. This conclusion affects various properties of the HTS cuprates, including the irreversibility behavior for transport in the ab planes, the direct c-axis transport and potentially the mechanism of Cooper pairing
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Effects of vortex-vortex interactions on ion-track pinning in high T{sub c} superconductors
Many superconductor applications rely on the ability to pin vortex lattices. This ability depends on structural defects to pin individual vortices, but vortex-vortex interactions often play an important role in pinning the other vortices. Experimental progress on this complex problem can be made by introducing random arrays of well-defined pinning centers and studying the flux dynamics for a range of vortex densities (i.e., fields). Results of such studies in epitaxial Tl{sub 2}Ba{sub 2}CaCu{sub 2}O{sub y} films containing ion tracks show the importance of vortex-vortex interactions. As an example, the effective pinning field of the defects rises to many times the ion-dose field for temperatures well below {Tc}
Editorial: emerging issues in sociotechnical systems thinking and workplace safety
The burden of on-the-job accidents and fatalities and the harm of associated human suffering continue to present an important challenge for safety researchers and practitioners. While significant improvements have been achieved in recent decades, the workplace accident rate remains unacceptably high. This has spurred interest in the development of novel
research approaches, with particular interest in the systemic influences of social/organisational and technological factors. In response, the Hopkinton Conference on Sociotechnical Systems and Safety was organised to assess the current state of knowledge in the area and to identify research priorities. Over the course of several months prior to the conference, leading international experts drafted collaborative, state-of-the-art reviews covering various aspects of sociotechnical systems and safety. These papers, presented in this special issue, cover topics ranging from the identification of key concepts and definitions to sociotechnical characteristics of safe and unsafe organisations. This paper provides an overview of the conference and introduces key themes and topics.
Practitioner Summary: Sociotechnical approaches to workplace safety are intended to draw practitioners’ attention to the critical influence that systemic social/organisational and technological factors exert on safety-relevant outcomes. This paper introduces major themes addressed in the Hopkinton Conference within the context of current workplace safety research and
practice challenge
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Determination of the temperature dependence of the penetration depth of Nb in Nb/AlO{sub x}/Nb Josephson junctions from a resistive measurement in a magnetic field
The temperature dependence of the penetration depth of Nb films was determined from resistive transitions of Nb/AlO{sub x}/Nb Josephson junctions in a constant magnetic field applied parallel to the junction planes. Distinct resistance peaks were observed as temperature decreases and those peaks were found to appear when the total flux threading the junction equals an integral multiple of the flux quantum. From this condition, the authors have determined the penetration depth at those peak positions. The temperature dependence was well described by the either dirty local limit or the two-fluid model. This method can be useful for highly fluctuating system like high-temperature superconductors
Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Progress in olfactory research is currently hampered by incomplete knowledge about chemical receptive ranges of primary receptors. Moreover, the chemical logic underlying the arrangement of computational units in the olfactory bulb has still not been resolved. We undertook a large-scale approach at characterising molecular receptive ranges (MRRs) of glomeruli in the dorsal olfactory bulb (dOB) innervated by the MOR18-2 olfactory receptor, also known as Olfr78, with human ortholog OR51E2. Guided by an iterative approach that combined biological screening and machine learning, we selected 214 odorants to characterise the response of MOR18-2 and its neighbouring glomeruli. We found that a combination of conventional physico-chemical and vibrational molecular descriptors performed best in predicting glomerular responses using nonlinear Support-Vector Regression. We also discovered several previously unknown odorants activating MOR18-2 glomeruli, and obtained detailed MRRs of MOR18-2 glomeruli and their neighbours. Our results confirm earlier findings that demonstrated tunotopy, that is, glomeruli with similar tuning curves tend to be located in spatial proximity in the dOB. In addition, our results indicate chemotopy, that is, a preference for glomeruli with similar physico-chemical MRR descriptions being located in spatial proximity. Together, these findings suggest the existence of a partial chemical map underlying glomerular arrangement in the dOB. Our methodology that combines machine learning and physiological measurements lights the way towards future high-throughput studies to deorphanise and characterise structure-activity relationships in olfaction.Peer reviewe
Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL
We performed sensitive polymerase chain reaction-based minimal residual
disease (MRD) analyses on bone marrow samples at 9 follow-up time points
in 71 children with T-lineage acute lymphoblastic leukemia (T-ALL) and
compared the results with the precursor B-lineage ALL (B-ALL) results (n =
210) of our previous study. At the first 5 follow-up time points, the
frequency of MRD-positive patients and the MRD levels were higher in T-ALL
than in precursor-B-ALL, reflecting the more frequent occurrence of
resistant disease in T-ALL. Subsequently, patients were classified
according to their MRD level at time point 1 (TP1), taken at the end of
induction treatment (5 weeks), and at TP2 just before the start of
consolidation treatment (3 months). Patients were considered at low risk
if TP1 and TP2 were MRD negative and at high risk if MRD levels at TP1 and
TP2 were 10(-3) or higher; remaining patients were considered at
intermediate risk. The relative distribution of patients with T-ALL (n =
43) over the MRD-based risk groups differed significantly from that of
precursor B-ALL (n = 109). Twenty-three percent of patients with T-ALL and
46% of patients with precursor B-ALL were classified in the low-risk group
(P =.01) and had a 5-year relapse-free survival (RFS) rate of 98% or
greater. In contrast, 28% of patients with T-ALL were classified in the
MRD-based high-risk group compared to only 11% of patients with precursor
B-ALL (P =.02), and the RFS rates were 0% and 25%, respectively (P =.03).
Not only was the distribution of patients with T-ALL different over the
MRD-based risk groups, the prognostic value of MRD levels at TP1 and TP2
was higher in T-ALL (larger RFS gradient), and consistently higher RFS
rates were found for MRD-negative T-ALL patients at the first 5 follow-up
time points
Theory of the c-Axis Penetration Depth in the Cuprates
Recent measurements of the London penetration depth tensor in the cuprates
find a weak temperature dependence along the c-direction which is seemingly
inconsistent with evidence for d-wave pairing deduced from in-plane
measurements. We demonstrate in this paper that these disparate results are not
in contradiction, but can be explained within a theory based on incoherent
quasiparticle hopping between the CuO2 layers. By relating the calculated
temperature dependence of the penetration depth \lambda_c(T) to the c-axis
resistivity, we show how the measured ratio \lambda_c^2(0) / \lambda_c^2(T) can
provide insight into the behavior of c-axis transport below Tc and the related
issue of ``confinement.''Comment: 4 pages, REVTEX with psfig, 3 PostScript figures included in
compressed for
Normal-superconducting transition induced by high current densities in YBa2Cu3O7-d melt-textured samples and thin films: Similarities and differences
Current-voltage characteristics of top seeded melt-textured YBa2Cu3O7-d are
presented. The samples were cut out of centimetric monoliths. Films
characteristics were also measured on microbridges patterned on thin films
grown by dc sputtering. For both types of samples, a quasi-discontinuity or
quenching was observed for a current density J* several times the critical
current density Jc. Though films and bulks much differ in their magnitude of
both Jc and J*, a proposal is made as to a common intrinsic origin of the
quenching phenomenon. The unique temperature dependence observed for the ratio
J*/Jc, as well as the explanation of the pre-quenching regime in terms of a
single dissipation model lend support to our proposal.Comment: 10 pages, 10 figures, submitted to Physical Review
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