A REVIEW ON A FLASH CHROMATOGRAPHY

ABSTRACT Flash chromatography is rapid form of preparative column chromatography-preparative liquid chromatography based upon an air pressure driven hybrid of medium and short column chromatography optimized for rapid separation of organic compounds. As technology has evolved available guidelines for normal-phase flash chromatography have become less relevant. Years of experience performing chromatography with disposable columns have been condensed into simple guidelines useful for translating TLC results into either isocratic-or gradient-flash chromatography. The described studies should provide researchers with a means of selecting adequate columns and guidelines to reduce the waste of solvents, silica, time, and money. Modern flash chromatography systems are sold as pre-packed plastic cartridges and the solvent is pumped through the cartridge. These systems may also be linked with detectors and fraction collectors providing automation. The introduction of gradient pumps has resulted in quicker separations and less solvent usage

A Survey On Image Mosaicing Using Feature Based Approach

Image mosaicing is consider as an active research area in computer vision and computer graphics. Image stitching techniques can be categorized into two approaches: Direct technique and Feature based techniques. Direct techniques compare all the pixel intensities of the images with each other, and Feature based techniques used to determine a relationship between images through distinct features extracted from the processed images

Future Pharmacological Armamentaria in Management of Alzheimer Disease

ABSTRACT Introduction: Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder and common cause of dementia in elderly. With advancing age, number of people suffering from AD is also increased. Exact aetiology of AD was not known and therapy was focused mainly on increasing central cholinergic transmission with drugs like donepazil, reivastigmine and galantamine. With the generation of amyloid hypothesis, extracellular amyloid plaques, consisting of amorphous extra cellular deposits of β-amyloid protein (known as Aβ) and intraneuronal neurofibrillary tangles(Tau) mainly in the hippocampus and frontal cortex ,altered processing of amyloid protein from its precursor (amyloid precursor protein, APP) recognised as the key to the pathogenesis of AD. But, now various studies have shown that etiology may be multifactorial. Inspite of having identified many potential targets, currently no drug modifying disease pathology is available .Advancement of the early diagnostic methods like positron emission tomography (PET) scan and measurement of various biomarkers like NO tagged proteins, ADAM-10 in c.s.f. could potentiate research to develop disease modifying drugs. Drugs modifying Y secretase, tyrosine kinase inhibitors, sigma receptor agonists, anti-Aβ monoclonal Abs are in the various stages of drug development and could become the cornerstone in the management of AD in future