11 research outputs found
Design and Implementation of a Studio-Based General Chemistry Course
Most students taking general chemistry courses do not intend to pursue careers in chemistry; in fact, they are more likely to end up in positions where they fund, write, or vote for chemical research and policies. Our profession continues to ask how we can teach students scientific reasoning skills and chemical understanding in general chemistry that they are able to take beyond the classroom into their everyday lives. The emerging answer at this university is the studio teaching method, which incorporates the “best teaching and learning practices†recommended by chemical education research within an integrated lecture–lab technology-intensive environment. The design, implementation, and pedagogical rationale of studio general chemistry are described
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Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes
It has long been recognized that cationic nanoparticles induce cell membrane permeability. Recently, it has been found that cationic nanoparticles induce the formation and/or growth of nanoscale holes in supported lipid bilayers. In this paper, we show that noncytotoxic concentrations of cationic nanoparticles induce 30−2000 pA currents in 293A (human embryonic kidney) and KB (human epidermoid carcinoma) cells, consistent with a nanoscale defect such as a single hole or group of holes in the cell membrane ranging from 1 to 350 nm2 in total area. Other forms of nanoscale defects, including the nanoparticle porating agents adsorbing onto or intercalating into the lipid bilayer, are also consistent; although the size of the defect must increase to account for any reduction in ion conduction, as compared to a water channel. An individual defect forming event takes 1−100 ms, while membrane resealing may occur over tens of seconds. Patch-clamp data provide direct evidence for the formation of nanoscale defects in living cell membranes. The cationic polymer data are compared and contrasted with patch-clamp data obtained for an amphiphilic phenylene ethynylene antimicrobial oligomer (AMO-3), a small molecule that is proposed to make well-defined 3.4 nm holes in lipid bilayers. Here, we observe data that are consistent with AMO-3 making ∼3 nm holes in living cell membranes
Biogeography and population structure of predominant macrofaunal taxa (Annelida and Isopoda) in abyssal polymetallic nodule fields: implications for conservation and management
Health coaching to improve self-management and quality of life for low income patients with chronic obstructive pulmonary disease (COPD): protocol for a randomized controlled trial
Supporting elderly people with cognitive impairment during and after hospital stays with intersectoral care management: study protocol for a randomized controlled trial
Innovative research methods in health social sciences : an introduction
Innovative, or creative research, methods have become increasingly popular in the last few decades. In this chapter, I will include several salient issues on which chapters in the section on “Innovative Research Methods in Health Social Sciences” can be situated. First, I discuss some ideas about innovative and creative methods. This is followed with the notion of those who practice innovative methods: the innovative researcher. I will then bring readers through a number of innovative and creative methods that researchers have adopted in their research. These include the theoretical lens, arts-based and visual research methods, the body and embodiment research, digital methods, and textual (plus visual) methods of inquiry. As an innovative researcher, our choice of innovative methods primarily depends on the questions we pose; the people who are involved; our moral, ethical, and methodological competence as researchers; and the sociocultural environment of the research. As we are living in the world that continue to change, it is likely that health and social science researchers will continue to experiment with their creative methods in order to ensure the success of their research. I anticipate that in the future, we will see even more creative methods that researchers will bring forth