Anaphylactic reaction at a pizzeria in a 13-year-old female patient

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose of Review</jats:title> <jats:p><jats:italic>Mycoplasma</jats:italic>, economically important pathogens in livestock, often establishes immunologically complex persistent infections that drive their pathogenesis and complicate prophylaxis and therapy of the caused diseases. In this review, we summarize some of the recent findings concerning cellular and molecular persistence mechanisms related to the pathogenesis of mycoplasma infections in livestock.</jats:p> </jats:sec><jats:sec> <jats:title>Recent Findings</jats:title> <jats:p>Data from recent studies prove several mechanisms including intracellular lifestyle, immune dysregulation, and autoimmunity as well as microcolony and biofilm formation and apoptosis of different host cell types as important persistence mechanisms in several clinically significant <jats:italic>Mycoplasma</jats:italic> species, i.e., <jats:italic>M. bovis</jats:italic>, <jats:italic>M</jats:italic>. <jats:italic>gallisepticum</jats:italic>, <jats:italic>M. hyopneumoniae</jats:italic>, and <jats:italic>M</jats:italic>. <jats:italic>suis</jats:italic>.</jats:p> </jats:sec><jats:sec> <jats:title>Summary</jats:title> <jats:p>Evasion of the immune system and the establishment of persistent infections are key features in the pathogenesis of livestock mycoplasmas. In-depth knowledge of the underlying mechanisms will provide the basis for the development of therapy and prophylaxis strategies against mycoplasma infections.</jats:p> </jats:sec&gt

Regional Competition in US Banking: Trends and Determinants

Competition in the US banking industry as measured by the Lerner Index has on average increased substantially during the last decade. At the same time, regional differences in competition on the state level have decreased considerably. Based on a dynamic panel framework we find that these developments are mainly driven by industry specific factors such as the costs to income ratio. The empirical evidence indicates that inefficiency and the Lerner index are significant negatively correlated. Macroeconomic conditions appear to have supported these trends in competition, however, to a somewhat lesser extent

Optimal Population Codes for Space: Grid Cells Outperform Place Cells

Rodents use two distinct neuronal coordinate systems to estimate their position: place fields in the hippocampus and grid fields in the entorhinal cortex. Whereas place cells spike at only one particular spatial location, grid cells fire at multiple sites that correspond to the points of an imaginary hexagonal lattice. We study how to best construct place and grid codes, taking the probabilistic nature of neural spiking into account. Which spatial encoding properties of individual neurons confer the highest resolution when decoding the animal’s position from the neuronal population response? A priori, estimating a spatial position from a grid code could be ambiguous, as regular periodic lattices possess translational symmetry. The solution to this problem requires lattices for grid cells with different spacings; the spatial resolution crucially depends on choosing the right ratios of these spacings across the population. We compute the expected error in estimating the position in both the asymptotic limit, using Fisher information, and for low spike counts, using maximum likelihood estimation. Achieving high spatial resolution and covering a large range of space in a grid code leads to a trade-off: the best grid code for spatial resolution is built of nested modules with different spatial periods, one inside the other, whereas maximizing the spatial range requires distinct spatial periods that are pairwisely incommensurate. Optimizing the spatial resolution predicts two grid cell properties that have been experimentally observed. First, short lattice spacings should outnumber long lattice spacings. Second, the grid code should be self-similar across different lattice spacings, so that the grid field always covers a fixed fraction of the lattice period. If these conditions are satisfied and the spatial “tuning curves” for each neuron span the same range of firing rates, then the resolution of the grid code easily exceeds that of the best possible place code with the same number of neurons

Resolution of Nested Neuronal Representations Can Be Exponential in the Number of Neurons

Collective computation is typically polynomial in the number of computational elements, such as transistors or neurons, whether one considers the storage capacity of a memory device or the number of floating-point operations per second of a CPU. However, we show here that the capacity of a computational network to resolve real-valued signals of arbitrary dimensions can be exponential in N, even if the individual elements are noisy and unreliable. Nested, modular codes that achieve such high resolutions mirror the properties of grid cells in vertebrates, which underlie spatial navigation

A physiologically inspired model for global remapping in the hippocampus

Europe PMC is an archive of life sciences journal literature., A physiologically inspired model for global remapping in the hippocampus

Fostering Efficiency in Information Systems Support for Product-Service Systems in the Manufacturing Industry

The ongoing shift towards stronger service orientation is leading to a rising number of industrial services offered in the manufacturing industry. In the attempt to fulfill ever-increasing service demands while at the same time reducing operating costs, manufacturing firms search for appropriate information technology (IT) solution for planning and execution. The industry has not yet reached a common understanding of product-service systems and the corresponding processes and IT systems. In order to holistically support such broad design and transformation tasks, we develop a maturity model capturing the key requirements for the information systems (IS) support of product-service systems based on a multiple case study. For a critical reflection on the extant literature, we compared those requirements with scientifically recognized maturity models and standard specifications. Being an integral part of the design science research approach, the model evaluation is organized in accordance with approved evaluation perspectives