As variáveis intervenientes na produção do onset complexo mediante uma análise silábica The intervening variables in the production of consonant clusters by syllabic analysis

OBJETIVO: verificar e comparar as estratégias de reparo e a influência das variáveis linguísticas (silábicas e prosódicas) e extralinguísticas na produção da sílaba com Onset Complexo em crianças com desenvolvimento fonológico típico e atípico. MÉTODO: foi analisada a fala de 48 crianças, 24 com desenvolvimento fonológico típico e 24 com desenvolvimento fonológico atípico, equiparados em relação ao sexo, entre 2:6 a 5:5;29 (grupo típico) e 5:0 a 7:11;29 (grupo atípico). As amostras foram coletadas transversalmente, com base no instrumento Avaliação Fonológica da Criança. Foram analisadas palavras que apresentaram como alvo o onset complexo, com um corpus de 278 palavras do desenvolvimento típico e 460 do desenvolvimento atípico. Foram consideradas como variantes da variável dependente a produção correta, apagamento de C², apagamento de C¹, apagamento de sílaba, epêntese, metátese e idiossincrasias. Como variáveis independentes intervenientes consideraram-se os fatores extralinguísticos idade, sexo e tipo de desenvolvimento e as variáveis linguísticas tonicidade, número de sílabas, contexto silábico seguinte e precedente, posição na palavra, complexidade do onset na própria sílaba e pé métrico. Os dados de fala foram analisados estatisticamente por meio do VARBRUL. RESULTADO: o programa estatístico selecionou como significante para a produção correta e para os outros tipos de estratégias de reparo do onset complexo as variáveis sexo, idade, tipo de desenvolvimento, posição na palavra, pé métrico e contexto silábico seguinte. CONCLUSÃO: verificou-se que as variáveis linguísticas e extralinguísticas influenciam significantemente na produção do onset complexo em crianças com ambos os desenvolvimentos. A estratégia de reparo mais utilizada foi apagamento de C².<br>PURPOSE: to verify and to compare the repair strategies and the influence of linguistic (syllabic and prosodic) and extralinguistic variables in the production of consonant clusters by children with typical and atypical phonological development. METHOD: it was analyzed the speech of 48 children, 24 with typical phonological development and 24 with atypical phonological development, similar in relation to sex, and age between 2:6 to 5:5;29 (typical group) and 5:0 to 7:11;29 (atypical group). The samples were collected transversely, based on the instrument Avaliação Fonológica da Criança. It was analyzed the words presented as target consonant clusters, with a corpus of 278 words of typical development and 460 of atypical development. The correct production, C² deletion, C¹ deletion, syllable deletion, epenthetic, metathesis and idiosyncrasies were considered as variants of the dependent variable. The extralinguistic factors such as age, sex and development type, and linguistic variables the number of syllables, next precedent syllabic context, the position in the word, the complexity of the onset in the syllable and metrical foot were considered as independent intervening variables. The speech data were statistically analyzed through VARBRUL. RESULTS: the statistical program selected as significant for the correct production and other types of repair strategies in the consonant clusters the variables sex, age, development type, position in the word, metrical foot and precedent syllabic context. CONCLUSION: it was found that the linguistic and extralinguistic variables significantly influence the production of consonant clusters in children with both developments. The most widely used repair strategy was the deletion of C²

Determination of the probability for locating peaks by computerised peak location methods in gamma-ray spectra as a function of the relative peak area uncertainty

22nd International Confeence on Radionuclide Metrology and its Applications; Salamanca, 2019

Duration of ruptured membranes and vertical transmission of HIV-1: a meta-analysis from 15 prospective cohort studies

Objective: To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Design: The relationship between duration of ruptured membranes and vertical transmission of HIV was evaluated in an individual patient data meta-analysis. Methods: Eligible studies were prospective cohort studies including at least 100 mother-child pairs, from regions where HIV-infected women are counselled not to breastfeed. Analyses were restricted to vaginal deliveries and non-elective Cesarean sections; elective Cesarean section deliveries (those performed before onset of labour and before rupture of membranes) were excluded. Results: The primary analysis included 4721 deliveries with duration of ruptured membranes less than or equal to 24 h. After adjusting for other factors known to be associated with vertical transmission using logistic regression analysis to assess the strength of the relationship, the risk of vertical HIV transmission increased approximately 2% with an increase of 1 h in the duration of ruptured membranes [adjusted odds ratio, 1.02; 95% confidence interval, 1.01-1.04; for each 1 h increment]. There were no significant interactions of duration of ruptured membranes with study cohort or with any of the covariates, except maternal AIDS. Among women diagnosed with AIDS, the estimated probability of transmission increased from 8% to 31% with duration of ruptured membranes of 2 h and 24 h respectively (P < 0.01). Conclusions: These results support the importance of duration of ruptured membranes as a risk factor for vertical transmission of HIV and suggest that a diagnosis of AIDS in the mother at the time of delivery may potentiate the effect of duration of ruptured membranes. (C) 2001 Lippincott Williams & Wilkins

Duration of ruptured membranes and vertical transmission of HIV-1: A meta-analysis from 15 prospective cohort studies

Objective: To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Design: The relationship between duration of ruptured membranes and vertical transmission of HIV was evaluated in an individual patient data meta-analysis. Methods: Eligible studies were prospective cohort studies including at least 100 mother-child pairs, from regions where HIV-infected women are counselled not to breastfeed. Analyses were restricted to vaginal deliveries and non-elective Cesarean sections; elective Cesarean section deliveries (those performed before onset of labour and before rupture of membranes) were excluded. Results: The primary analysis included 4721 deliveries with duration of ruptured membranes ≤ 24 h. After adjusting for other factors known to be associated with vertical transmission using logistic regression analysis to assess the strength of the relationship, the risk of vertical HIV transmission increased approximately 2% with an increase of 1 h in the duration of ruptured membranes [adjusted odds ratio, 1.02; 95% confidence interval, 1.01-1.04; for each 1 h increment]. There were no significant interactions of duration of ruptured membranes with study cohort or with any of the covariates, except maternal AIDS. Among women diagnosed with AIDS, the estimated probability of transmission increased from 8% to 31% with duration of ruptured membranes of 2 h and 24 h respectively (P &lt; 0.01). Conclusions: These results support the importance of duration of ruptured membranes as a risk factor for vertical transmission of HIV and suggest that a diagnosis of AIDS in the mother at the time of delivery may potentiate the effect of duration of ruptured membranes. © 2001 Lippincott Williams &amp; Wilkins

The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1--a meta-analysis of 15 prospective cohort studies. The International Perinatal HIV Group.

To evaluate the relation between elective cesarean section and vertical transmission of human immunodeficiency virus type 1 (HIV-1), we performed a meta-analysis using data on individual patients from 15 prospective cohort studies. North American and European studies of at least 100 mother-child pairs were included in the meta-analysis. Uniform definitions of modes of delivery were used. Elective cesarean sections were defined as those performed before onset of labor and rupture of membranes. Multivariate logistic-regression analysis was used to adjust for other factors known to be associated with vertical transmission. The primary analysis included data on 8533 mother-child pairs. After adjustment for receipt of antiretroviral therapy, maternal stage of disease, and infant birth weight, the likelihood of vertical transmission of HIV-1 was decreased by approximately 50 percent with elective cesarean section, as compared with other modes of delivery (adjusted odds ratio, 0.43; 95 percent confidence interval, 0.33 to 0.56). The results were similar when the study population was limited to those with rupture of membranes shortly before delivery. The likelihood of transmission was reduced by approximately 87 percent with both elective cesarean section and receipt of antiretroviral therapy during the prenatal, intrapartum, and neonatal periods, as compared with other modes of delivery and the absence of therapy (adjusted odds ratio, 0.13; 95 percent confidence interval, 0.09 to 0.19). Among mother-child pairs receiving antiretroviral therapy during the prenatal, intrapartum, and neonatal periods, rates of vertical transmission were 2.0 percent among the 196 mothers who underwent elective cesarean section and 7.3 percent among the 1255 mothers with other modes of delivery. The results of this meta-analysis suggest that elective cesarean section reduces the risk of transmission of HIV-1 from mother to child independently of the effects of treatment with zidovudine

The Mode Of Delivery And The Risk Of Vertical Transmission Of Human Immunodeficiency Virus Type 1. A Meta-Analysis Of 15 Prospective Cohort Studies

Background To evaluate the relation between elective cesarean section and vertical transmission of human immunodeficiency virus type 1 (HIV-1), we performed a meta-analysis using data on individual patients from 15 prospective cohort studies. Methods North American and European studies of at least 100 mother-child pairs were included in the meta-analysis. Uniform definitions of modes of delivery were used. Elective cesarean sections were defined as those performed before onset of labor and rupture of membranes. Multivariate logistic-regression analysis was used to adjust for other factors known to be associated with vertical transmission. Results The primary analysis included data on 8533 mother-child pairs. After adjustment for receipt of antiretroviral therapy, maternal stage of disease, and infant birth weight, the likelihood of vertical transmission of HIV-1 was decreased by approximately 50 percent with elective cesarean section, as compared with other modes of delivery (adjusted odds ratio, 0.43; 95 percent confidence interval, 0.33 to 0.56). The results were similar when the study population was limited to those with rupture of membranes shortly before delivery. The likelihood of transmission was reduced by approximately 87 percent with both elective cesarean section and receipt of antiretroviral therapy during the prenatal, intrapartum, and neonatal periods, as compared with other modes of delivery and the absence of therapy (adjusted odds ratio, 0.13; 95 percent confidence interval, 0.09 to 0.19), Among mother-child pairs receiving antiretroviral therapy during the prenatal, intrapartum, and neonatal periods, rates of vertical transmission were 2.0 percent among the 196 mothers who underwent elective cesarean section and 7.3 percent among the 1255 mothers with other modes of delivery. Conclusions The results of this meta-analysis suggest that elective cesarean section reduces the risk of transmission of HIV-1 from mother to child independently of the effects of treatment with zidovudine. (N Engl J Med 1999;340:977-87.) (C)1999, Massachusetts Medical Society