Tau Phosphorylation, Aggregation, and Cell Toxicity

Protein aggregation takes place in many neurodegenerative disorders. However, there is a controversy about the possible toxicity of these protein aggregates. In this review, this controversy is discussed, focussing on the tau aggregation that takes place in those disorders known as tauopathies

BVRI Surface Photometry of (S+S) Binary Galaxies. I. The data

We present multicolour broad band ($BVRI$) photometry for a sample of 33 spiral-spiral (S+S) binary galaxies drawn from the Karachentsev Catalogue of Isolated Pairs of Galaxies (KPG). The data is part of a joint observational programme devoted to systematic photometric study of one of the most complete and homogeneous pair samples available in the literature. We present azimuthally averaged colour and surface brightness profiles, colour index (B-I) maps, B band and sharp/filtered B band images as well as integrated magnitudes, magnitudes at different circular apertures and integrated colours for each pair. Internal and external data comparisons show consistency within the estimated errors. Two thirds of the sample have total aperture parameters homogeneously derived for the first time. After reevaluating morphology for all the pairs, we find a change in Hubble type for 24 galaxies compared to the original POSS classifications. More than half of our pairs show morphological concordance which could explain, in part, the strong correlation in the (B-V) colour indices (Holmberg Effect) between pair components. We find a tendency for barred galaxies to show grand design morphologies and flat colour profiles. The measurements will be used in a series of forthcoming papers where we try to identify and isolate the main structural and photometric properties of disk galaxies at different stages of interaction.Comment: 23 pages. 5 Figures. Accepted for publication in Astronomy and Astrophysics. Mosaics for all pairs can be found at http://www.inaoep.mx/~puerari/binar

The Effects of Interactions on the Structure and Morphology of Elliptical/Lenticular galaxies in Pairs

We present a photometric and structural analysis of 42 E/S0 galaxies in (E/S0 + S) pairs observed in the BVRI color bands. We empirically determine the effects of interactions on their morphology, structure and stellar populations as seen from the light concentration (C), asymmetry (A), and clumpiness (S) parameters. We further compare these values to a control sample of 67 mostly isolated, non-interacting E/S0 galaxies. The paired E/S0 galaxies occupy a more scattered loci in CAS space than non-interacting E/S0's, and the structural effects of interactions on E/S0's are minor, in contrast to disk galaxies involved in interactions. This suggests that observational methods for recognizing interactions at high z, such the CAS methodology, would hardly detect E/S0's involved in interactions (related to early phases of the so called `dry-mergers'). We however find statistical differences in A when comparing isolated and interacting E/S0s. In the mean, paired E/S0 galaxies have A values 2.96+-0.72 times larger than the ones of non-interacting E/S0's. For the subset of presumably strongly interacting E/S0's, A and S can be several times larger than the typical values of the isolated E/S0's. We show that the asymmetries are consistent with several internal and external morphological distortions. We conclude that the interacting E/S0s in pairs should be dense, gas poor galaxies in systems spaning a wide range of interaction stages, with typical merging timescales >~ 0.1-0.5 Gyr. We use the observed phenomenology of these galaxies to predict the approximate loci of `dry pre-mergers' in the CAS space.(Abridged)Comment: 23 pages, 9 figures included. To appear in The Astronomical Journa

SDSS-IV MaNGA: global and local stellar population properties of elliptical galaxies

We study the spatially resolved properties of 343 elliptical galaxies with the MaNGA/SDSS-IV survey. We used the DESI Legacy Imaging Surveys for morphological classification. Based on integrated spectroscopic properties and colors, we classified seven classes of ellipticals. We inferred the stellar age and metallicity ($Z$) gradients out to a 1.5 effective radius of classical "red and dead", recently quenched, and blue star-forming ellipticals (CLEs, RQEs, and BSFs), corresponding to 73%, 10%, and 4% of the sample, respectively. We reconstructed their global and radial histories of star formation and mass growth. We find the mass- and luminosity-weighted age gradients of CLEs are nearly flat or mildly negative. The respective $Z$ gradients are negative, being flatter as the mass is smaller. The more massive CLEs formed stars earlier and quenched faster than the less massive ones. The CLEs show a weak inside-out growth and a clear inside-out quenching. They finished their quenching globally 3.8 $\pm$ 1.2 Gyr ago, with quenching time-scales of 3.4 $\pm$ 0.8 Gyr. At masses < 10$^{11}$ $M_{\bigodot}$, the age and $Z$ gradients of the RQEs and BSFs are flatter than those of the CLEs but with larger scatters. They show very weak inside-out growth and quenching, which is slow and even not completed at $z\sim0$ for the BSFs. Instead, the massive RQEs show an outside-in quenching and positive gradients in the luminosity-weighted age and stellar metallicities. The RQEs of all masses quenched 1.2 $\pm$ 0.9 Gyr ago on average. Our results for the CLEs are consistent with a two-phase scenario where their inner parts formed by an early and coeval dissipative collapse with a consequent burst of star formation and further quenching, whereas the outer parts continued their assembly likely by dry mergers. We also discuss some evolutionary scenarios for the RQE and BSF galaxies.Comment: 24 pages and 18 figures without appendix. We added Table 1 with a list of acronyms. Original article published in Astronomy & Astrophysic

ESPRESSO: The next European exoplanet hunter

The acronym ESPRESSO stems for Echelle SPectrograph for Rocky Exoplanets and Stable Spectroscopic Observations; this instrument will be the next VLT high resolution spectrograph. The spectrograph will be installed at the Combined-Coud\'e Laboratory of the VLT and linked to the four 8.2 m Unit Telescopes (UT) through four optical Coud\'e trains. ESPRESSO will combine efficiency and extreme spectroscopic precision. ESPRESSO is foreseen to achieve a gain of two magnitudes with respect to its predecessor HARPS, and to improve the instrumental radial-velocity precision to reach the 10 cm/s level. It can be operated either with a single UT or with up to four UTs, enabling an additional gain in the latter mode. The incoherent combination of four telescopes and the extreme precision requirements called for many innovative design solutions while ensuring the technical heritage of the successful HARPS experience. ESPRESSO will allow to explore new frontiers in most domains of astrophysics that require precision and sensitivity. The main scientific drivers are the search and characterization of rocky exoplanets in the habitable zone of quiet, nearby G to M-dwarfs and the analysis of the variability of fundamental physical constants. The project passed the final design review in May 2013 and entered the manufacturing phase. ESPRESSO will be installed at the Paranal Observatory in 2016 and its operation is planned to start by the end of the same year.Comment: 12 pages, figures included, accepted for publication in Astron. Nach

Association between the plasma/whole blood lead ratio and history of spontaneous abortion: a nested cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Blood lead has been associated with an elevated risk of miscarriage. The plasmatic fraction of lead represents the toxicologically active fraction of lead. Women with a tendency to have a higher plasma/whole blood Pb ratio could tend towards an elevated risk of miscarriage due to a higher plasma Pb for a given whole blood Pb and would consequently have a history of spontaneous abortion.</p> <p>Methods</p> <p>We studied 207 pregnant Mexico City residents during the 1^sttrimester of pregnancy, originally recruited for two cohorts between 1997 and 2004. Criteria for inclusion in this study were having had at least one previous pregnancy, and having valid plasma and blood Pb measurements. Pb was measured in whole blood and plasma by inductively coupled plasma mass spectrometry using ultra-clean techniques. History of miscarriage in previous pregnancies was obtained by interview. The incidence rate of spontaneous abortion was defined as the proportion of previous pregnancies that resulted in miscarriage. Data were analyzed by means of Poisson regression models featuring the incidence rate of spontaneous abortion as the outcome and continuous or categorized plasma/blood Pb ratios as predictor variables. All models were adjusted for age and schooling. Additionally, logistic regression models featuring inclusion in the study sample as the outcome were fitted to assess potential selection bias.</p> <p>Results</p> <p>The mean number of miscarriages was 0.42 (range 0 to 4); mean Pb concentrations were 62.4 and 0.14 μg/L in whole blood and plasma respectively. Mean plasma/blood Pb ratio was 0.22%. We estimated that a 0.1% increment in the plasma/blood Pb ratio lead was associated to a 12% greater incidence of spontaneous abortion (p = 0.02). Women in the upper tertile of the plasma/blood Pb ratio had twice the incidence rate of those in the lower tertile (p = 0.02). Conditional on recruitment cohort, inclusion in the study sample was unrelated to observable characteristics such as number of abortions, number of pregnancies, blood Pb levels, age schooling, weight and height.</p> <p>Conclusion</p> <p>Women with a large plasma/whole blood Pb ratio may be at higher risk of miscarriage, which could be due to a greater availability of placental barrier-crossing Pb.</p

Dietary intake, lung function and airway inflammation in Mexico City school children exposed to air pollutants

<p>Abstract</p> <p>Introduction</p> <p>Air pollutant exposure has been associated with an increase in inflammatory markers and a decline in lung function in asthmatic children. Several studies suggest that dietary intake of fruits and vegetables might modify the adverse effect of air pollutants.</p> <p>Methods</p> <p>A total of 158 asthmatic children recruited at the Children's Hospital of Mexico and 50 non-asthmatic children were followed for 22 weeks. Pulmonary function was measured and nasal lavage collected and analyzed every 2 weeks. Dietary intake was evaluated using a 108-item food frequency questionnaire and a fruit and vegetable index (FVI) and a Mediterranean diet index (MDI) were constructed. The impact of these indices on lung function and interleukin-8 (IL-8) and their interaction with air pollutants were determined using mixed regression models with random intercept and random slope.</p> <p>Results</p> <p>FVI was inversely related to IL-8 levels in nasal lavage (p < 0.02) with a significant inverse trend (test for trend p < 0.001), MDI was positively related to lung function (p < 0.05), and children in the highest category of MDI had a higher FEV₁(test for trend p < 0.12) and FVC (test for trend p < 0.06) than children in the lowest category. A significant interaction was observed between FVI and ozone for FEV₁and FVC as was with MDI and ozone for FVC. No effect of diet was observed among healthy children.</p> <p>Conclusion</p> <p>Our results suggest that fruit and vegetable intake and close adherence to the Mediterranean diet have a beneficial effect on inflammatory response and lung function in asthmatic children living in Mexico City.</p

VAMOS: a Pathfinder for the HAWC Gamma-Ray Observatory

VAMOS was a prototype detector built in 2011 at an altitude of 4100m a.s.l. in the state of Puebla, Mexico. The aim of VAMOS was to finalize the design, construction techniques and data acquisition system of the HAWC observatory. HAWC is an air-shower array currently under construction at the same site of VAMOS with the purpose to study the TeV sky. The VAMOS setup included six water Cherenkov detectors and two different data acquisition systems. It was in operation between October 2011 and May 2012 with an average live time of 30%. Besides the scientific verification purposes, the eight months of data were used to obtain the results presented in this paper: the detector response to the Forbush decrease of March 2012, and the analysis of possible emission, at energies above 30 GeV, for long gamma-ray bursts GRB111016B and GRB120328B.Comment: Accepted for pubblication in Astroparticle Physics Journal (20 pages, 10 figures). Corresponding authors: A.Marinelli and D.Zaboro