AGB and SAGB stars: modelling dust production at solar metallicity

We present dust yields for asymptotic giant branch (AGB) and super--asymptotic giant branch (SAGB) stars of solar metallicity. Stars with initial mass $1.5~M_{\odot} \leq M_{\rm ini} \leq 3~M_{\odot}$ reach the carbon star stage during the AGB phase and produce mainly solid carbon and SiC. The size and the amount of the carbon particles formed follows a positive trend with themass of the star; the carbon grains with the largest size ($a_{\rm C} \sim 0.2\mu$m) are produced by AGB stars with $M_{\rm ini} = 2.5-3~M_{\odot}$, as these stars are those achieving the largest enrichment of carbon in the surface regions. The size of SiC grains, being sensitive to the surface silicon abundance, keeps around $a_{\rm SiC} \sim 0.1\mu$m. The mass of carbonaceous dust formed is in the range $10^{-4} - 5\times 10^{-3}~M_{\odot}$, whereas the amount of SiC produced is $2\times 10^{-4} - 10^{-3}~M_{\odot}$. Massive AGB/SAGB stars with $M_{\rm ini} > 3~M_{\odot}$ experience HBB, that inhibits formation of carbon stars. The most relevant dust species formed in these stars are silicates and alumina dust, with grain sizes in the range $0.1\mu m < a_{\rm ol} < 0.15\mu$m and $a_{\rm Al_2O_3} \sim 0.07\mu$m, respectively. The mass of silicates produced spans the interval $3.4\times 10^{-3}~M_{\odot} \leq M_{\rm dust} \leq 1.1\times 10^{-2}~M_{\odot}$ and increases with the initial mass of the star.Comment: Accepted for publication in MNRA

Limited effect of highly active antiretroviral therapy among HIV-positive injecting drug users on the population level

There is evidence that HIV-positive injecting drug users benefit less than other risk groups from highly active antiretroviral therapy that has been available since 1996. In this multicentre European study the impact of the availability of highly active antiretroviral therapy on the progression rates to AIDS and death among injecting drug users with a documented date of HIV seroconversion is studied. After highly active antiretroviral therapy became available the risk of AIDS and death for injecting drug users decreased by 28% and 36%, which is less than has been reported for other risk group

Realizations of Real Low-Dimensional Lie Algebras

Using a new powerful technique based on the notion of megaideal, we construct a complete set of inequivalent realizations of real Lie algebras of dimension no greater than four in vector fields on a space of an arbitrary (finite) number of variables. Our classification amends and essentially generalizes earlier works on the subject. Known results on classification of low-dimensional real Lie algebras, their automorphisms, differentiations, ideals, subalgebras and realizations are reviewed.Comment: LaTeX2e, 39 pages. Essentially exetended version. Misprints in Appendix are correcte

A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA

A method is described for the detection of certain nucleotide modifications adjacent to the 5' 7-methyl guanosine cap of mRNAs from individual genes. The method quantitatively measures the relative abundance of 2'-O-methyl and N6,2'-O-dimethyladenosine, two of the most common modifications. In order to identify and quantitatify the amounts of N6,2'-O-dimethyladenosine, a novel method for the synthesis of modified adenosine phosphoramidites was developed. This method is a one step synthesis and the product can directly be used for the production of N6,2'-O-dimethyladenosine containing RNA oligonucleotides. The nature of the cap-adjacent nucleotides were shown to be characteristic for mRNAs from individual genes transcribed in liver and testis

Deficiency of the Mitochondrial Electron Transport Chain in Muscle Does Not Cause Insulin Resistance

It has been proposed that muscle insulin resistance in type 2 diabetes is due to a selective decrease in the components of the mitochondrial electron transport chain and results from accumulation of toxic products of incomplete fat oxidation. The purpose of the present study was to test this hypothesis.Rats were made severely iron deficient, by means of an iron-deficient diet. Iron deficiency results in decreases of the iron containing mitochondrial respiratory chain proteins without affecting the enzymes of the fatty acid oxidation pathway. Insulin resistance was induced by feeding iron-deficient and control rats a high fat diet. Skeletal muscle insulin resistance was evaluated by measuring glucose transport activity in soleus muscle strips. Mitochondrial proteins were measured by Western blot. Iron deficiency resulted in a decrease in expression of iron containing proteins of the mitochondrial respiratory chain in muscle. Citrate synthase, a non-iron containing citrate cycle enzyme, and long chain acyl-CoA dehydrogenase (LCAD), used as a marker for the fatty acid oxidation pathway, were unaffected by the iron deficiency. Oleate oxidation by muscle homogenates was increased by high fat feeding and decreased by iron deficiency despite high fat feeding. The high fat diet caused severe insulin resistance of muscle glucose transport. Iron deficiency completely protected against the high fat diet-induced muscle insulin resistance.The results of the study argue against the hypothesis that a deficiency of the electron transport chain (ETC), and imbalance between the ETC and β-oxidation pathways, causes muscle insulin resistance