4-Meth­oxy-N-[6-methyl-2,3-dihydro-1,3-benzothia­zol-2-yl­idene]benzene­sulfonamide

The title compound, C15H14N2O3S2, is of inter­est with respect to its biological activity. The crystal structure is stabilized by inter­molecular N—H⋯N, C—H⋯O and C—H⋯π hydrogen-bonding inter­actions, as well as offset π–π inter­actions [distance between the centroids of the aryl and thiazole rings of adjacent molecules of 3.954 (2) Å]

Vasorelaxant activity of Euphorbia furcillata Kunth mainly by activation of NO/cGMP pathway and calcium channel blockade

The aim of current study was to determinate ex vivo and chromatographic fingerprint by HPLC of four extracts of Euphorbia furcillata K. Ethyl acetate extract of Euphorbia furcillata (EaEEf) was the most effective and potent extract (Emax=98.69±1.24%) and its effect was partially endothelium-dependent. Functional vasorelaxant mechanism of action of EaEEf was determinate, EaEEf showed efficient relaxation of KCl [80 mM]-induced contraction and norepinephrine and CaCl2 contraction curves showed diminution of maximal contraction in the presence of EAEEf and EaEEf-relaxation curve was shifted to the right in the presence of L-NAME (nitric oxide synthase inhibitor) and ODQ (guanylate cyclase inhibitor). Chromatographic fingerprints analysis suggests presence of diterpenoid such as abietane, tigliane, and ingenane skeletons. Our experiments suggest the EaEEf vasorelaxant activity could be attributed to diterpenoid molecules whose mechanism involves nitric oxide production and calcium channel blockade

2-(2-Benzyloxyphenyl)-1H-benzimidazole

The asymmetric unit of the title compound, C20H16N2O, contains two molecules. The dihedral angles between the benzimidazole ring systems and the attached benzene rings are 10.6 (5) and 13.7 (5)°. The conformers are linked by bifurcated three-centre hydrogen bonds, forming chains along the diagonal of the ab plane. The packing is further stabilized by π–π and C—H...π interactions