Scoping Studies of Dopants for Stabilization of Uranium Nitride Fuel

Uranium nitride (UN) is considered as nuclear reactor fuel because of, among other reasons, its high uranium density and its high thermal conductivity. Its main drawback is that it relatively easily dissolves in hot water, which is particularly problematic when it is used in water-cooled reactors. One possible remedy to this is to add some corrosion inhibitor as dopant to the UN matrix. A number of dopants have been identified that have the potential to inhibit the dissolution process, and their respective merits have been investigated both by neutronic simulations and dissolution experiments. It is concluded that chromium is the most promising candidate

Sunitinib-induced hypothyroidism predicts progression-free survival in metastatic renal cell carcinoma patients

Sunitinib is a tyrosine kinase inhibitor (TKI) used in treatment of metastatic renal cell carcinoma (mRCC), gastrointestinal stromal tumors and pancreatic neuroendocrine tumors. One of the most common side effects related to sunitinib is hypothyroidism. Recent trials suggest correlation between the incidence of hypothyroidism and treatment outcome in patients treated with TKI. This study evaluates whether development of hypothyroidism is a predictive marker of progression-free survival (PFS) in patients with mRCC treated with sunitinib. Twenty-seven patients diagnosed with clear cell mRCC, after nephrectomy and in ‘good’ or ‘intermediate’ MSKCC risk prognostic group, were included in the study. All patients received sunitinib as a first-line treatment on a standard schedule (initial dose 50 mg/day, 4 weeks on, 2 weeks off). The thyroid-stimulating hormone serum levels were obtained at the baseline and every 12 weeks of treatment. In statistic analyses, we used Kaplan–Meier method for assessment of progression-free survival; for comparison of survival, we used log-rank test. In our study, the incidence of hypothyroidism was 44%. The patients who had developed hypothyroidism had better median PFS to patients with normal thyroid function 28,3 months [95% (CI) 20.4–36.2 months] versus 9.8 months (6.4–13.1 months). In survival analysis, we perceive that thyroid dysfunction is a predictive factor of a progression-free survival (PFS). In the unified group of patients, the development of hypothyroidism during treatment with sunitinib is a positive marker for PFS. During that treatment, thyroid function should be evaluated regularly

Two Candidate High-Redshift X-ray Jets Without Coincident Radio Jets

We report the detection of extended X-ray emission from two high-redshift radio quasars. These quasars, J1405+0415 at $z$=3.208 and J1610+1811 at $z$=3.118, were observed in a Chandra snapshot survey selected from a complete sample of the radio-brightest quasars in the overlap area of the VLA-FIRST radio survey and the Sloan Digital Sky Survey. The extended X-ray emission is located along the line connecting the core to a radio knot or hotspot, favoring the interpretation of X-ray jets. The inferred rest frame jet X-ray luminosities from 2--30 keV would be of order 10$^{45}$ erg~s$^{-1}$ if emitted isotropically and without relativistic beaming. In the scenario of inverse Compton scattering of the cosmic microwave background (CMB), X-ray jets without a coincident radio counterpart may be common, and should be readily detectable to redshifts even beyond 3.2 due to the (1+$z$)$^4$ increase of the CMB energy density compensating for the (1+$z$)$^{-4}$ cosmological diminution of surface brightness. If these can be X-ray confirmed, they would be the second and third examples of quasar X-ray jets without detection of underlying continuous radio jets.Comment: 10 pages, 4 figures. Accepted for publication in The Astrophysical Journa

Decreased expression of the Slc31a1 gene and cytoplasmic relocalization of membrane CTR1 protein in renal epithelial cells : a potent protective mechanism against copper nephrotoxicity in a mouse model of Menkes disease

Kidneys play an especial role in copper redistribution in the organism. The epithelial cells of proximal tubules perform the functions of both copper uptake from the primary urine and release to the blood. These cells are equipped on their apical and basal membrane with copper transporters CTR1 and ATP7A. Mosaic mutant mice displaying a functional dysfunction of ATP7A are an established model of Menkes disease. These mice exhibit systemic copper deficiency despite renal copper overload, enhanced by copper therapy, which is indispensable for their life span extension. The aim of this study was to analyze the expression of Slc31a1 and Slc31a2 genes (encoding CTR1/CTR2 proteins) and the cellular localization of the CTR1 protein in suckling, young and adult mosaic mutants. Our results indicate that in the kidney of both intact and copper-injected 14-day-old mutants showing high renal copper content, CTR1 mRNA level is not up-regulated compared to wild-type mice given a copper injection. The expression of the Slc31a1 gene in 45-day-old mice is even reduced compared with intact wild-type animals. In suckling and young copper-injected mutants, the CTR1 protein is relocalized from the apical membrane to the cytoplasm of epithelial cells of proximal tubules, the process which prevents copper transport from the primary urine and, thus, protects cells against copper toxicity

Exacerbation of neonatal hemolysis and impaired renal iron handling in heme oxygenase 1-deficient mice

In most mammals, neonatal intravascular hemolysis is a benign and moderate disorder that usually does not lead to anemia. During the neonatal period, kidneys play a key role in detoxification and recirculation of iron species released from red blood cells (RBC) and filtered out by glomeruli to the primary urine. Activity of heme oxygenase 1 (HO1), a heme-degrading enzyme localized in epithelial cells of proximal tubules, seems to be of critical importance for both processes. We show that, in HO1 knockout mouse newborns, hemolysis was prolonged despite a transient state and exacerbated, which led to temporal deterioration of RBC status. In neonates lacking HO1, functioning of renal molecular machinery responsible for iron reabsorption from the primary urine (megalin/cubilin complex) and its transfer to the blood (ferroportin) was either shifted in time or impaired, respectively. Those abnormalities resulted in iron loss from the body (excreted in urine) and in iron retention in the renal epithelium. We postulate that, as a consequence of these abnormalities, a tight systemic iron balance of HO1 knockout neonates may be temporarily affected

Optical detection of the Pictor A jet and tidal tail : evidence against an IC/CMB jet

Date of Acceptance: 12/06/2015New images of the FR II radio galaxy Pictor A from the Hubble Space Telescope reveal a previously undiscovered tidal tail, as well as a number of jet knots coinciding with a known X-ray and radio jet. The tidal tail is approximately 5″ wide (3 kpc projected), starting 18″ (12 kpc) from the center of Pictor A, and extends more than 90″ (60 kpc). The knots are part of a jet observed to be about 4′ (160 kpc) long, extending to a bright hotspot. These images are the first optical detections of this jet, and by extracting knot flux densities through three filters, we set constraints on emission models. While the radio and optical flux densities are usually explained by synchrotron emission, there are several emission mechanisms that might be used to explain the X-ray flux densities. Our data rule out Doppler-boosted inverse Compton scattering as a source of the high-energy emission. Instead, we find that the observed emission can be well described by synchrotron emission from electrons with a low-energy index (p ∼ 2) that dominates the radio band, while a high-energy index (p ∼ 3) is needed for the X-ray band and the transition occurs in the optical/infrared band. This model is consistent with a continuous electron injection scenario.Peer reviewedFinal Accepted Versio

POTENTIAL FOR SUSTAINABLE DEVELOPMENT OF RURAL COMMUNITIES BY COMMUNITY-BASED ECOTOURISM A CASE STUDY OF RURAL VILLAGE PASTANGA, SIKKIM HIMALAYA, INDIA

Poverty is one of the most pressing global problems of the world today. One promising option to provide employment opportunities for the inhabitants of underdeveloped rural areas is the development of ‘pro-poor tourism’. Poverty alleviation tourism can generate environmental benefits in addition to economic, social and cultural ones. This study aims to discuss the possibilities of poverty alleviation of rural communities through the development of community-based ecotourism. The introductory part of the study briefly defines the theoretical frameworks of the concept of poverty and ecotourism in the context of sustainable development. Using the specific example of the Mid-Himalayan Rural village of Pastanga (India), show the potential areas for developing community-based ecotourism with respect to the local development opportunities. In the same way that is draw on our own research as well as available statistical data from the East Sikkim and Questionnaire Survey-2021. The case study presents the current extent of adventure trekking tourism and highlights the trends, characteristics and significance of trekking in Pastanga-Khedi eco-trail. The paper also propose strategies for exploring the trekking potential through the emphasis on ecotourism in the study area. In conclusion, we propose solutions for the regulated development of the area in a participatory way by the concerned stakeholders by implementing activities related to the Community-Based Ecotourism

Macrocytosis during sunitinib treatment predicts progression-free survival in patients with metastatic renal cell carcinoma

Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor, is a first-line treatment for metastatic renal cell carcinoma (mRCC) in patients in ‘low’ and ‘intermediate’ Memorial Sloan Kettering Cancer Center and Heng risk groups. Disruptions of hematopoiesis, such as anemia, neutropenia, and thrombocytopenia, are typically observed during sunitinib treatment. When it comes to RBC parameters, an increase in mean cell volume (MCV) tends to occur, meeting the criteria for macrocytosis in some patients (MCV > 100 fL). We examined changes in RBC parameters of 27 mRCC patients treated with sunitinib (initial dose of 50 mg/day, 6-week treatment: 4 weeks on, 2 weeks off) and correlated them with progression-free survival time (PFS). Patients who had macrocytosis after 3 treatment cycles had significantly longer PFS than those whose MCV stayed less than 100 fL (not reached vs. 11.2 months, p < 0.001). We also found a correlation between MCV values after the first and third treatment cycles and the risk of progression: HR of 0.9 (0.81–0.99) and 0.76 (0.65–0.90) per 1 fL increase in MCV, respectively. The mechanism of MCV elevation during sunitinib treatment has not yet been fully explained. One of the probable causes is sunitinib’s inhibitory influence on c-Kit kinase, as is the case with imatinib. For mRCC patients, this phenomenon could help predict PFS, but since our sample was small, further studies are essential

The Effect of Contrast Medium SonoVue® on the Electric Charge Density of Blood Cells

The effect of contrast medium SonoVue® on the electric charge density of blood cells (erythrocytes and thrombocytes) was measured using a microelectrophoretic method. We examined the effect of adsorbed H+ and OH− ions on the surface charge of erythrocytes or thrombocytes. Surface charge density values were determined from electrophoretic mobility measurements of blood cells performed at various pH levels. The interaction between solution ions and the erythrocyte’s or thrombocyte’s surface was described by a four-component equilibrium model. The agreement between the experimental and theoretical charge variation curves of the erythrocytes and thrombocytes was good at pH 2–9. The deviation observed at a higher pH may be caused by disregarding interactions between the functional groups of blood cells