Haneke avec Foucault: The White Ribbon, Religion, and Violence

This article utilizes Michel Foucault\u27s characterization of the Christian pastorate to examine The White Ribbon (2009), directed by Michael Haneke. Foucault\u27s framework assists us in inspecting the nature of the Protestant community depicted in the film, its systems of discipline, repression, and control, and the bond between these systems and the violence that erupts as the plot unfolds. Reading Haneke avec Foucault thus sheds light on the broader problem of religious violence, while also drawing out the sometimes submerged but skillful interpretation of religion proposed by these two auteurs

Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine

Non peer reviewe

Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late onset Alzheimer's disease (LOAD)

AbstractBackgroundDiverse research approaches support the concept that a clinical diagnosis of Late-Onset Alzheimer's Disease (LOAD) does not distinguish between subpopulations with differing neuropathologies, including dementia patients with amyloid deposition and dementia patients without amyloid deposition but with cortical thinning. Mild cognitive impairment (MCI) is generally considered the prodromal phase for LOAD, however, while a number of studies have attempted to define plasma biomarkers for the conversion of MCI to LOAD, these studies have not taken into account the heterogeneity of patient cohorts within a clinical phenotype.MethodsStudies of MCI and LOAD in several laboratories have demonstrated decrements in ethanolamine plasmalogen levels in plasma and brain and increased levels of diacylglycerols in plasma and brain. To further extend these studies and to address the issue of heterogeneity in MCI and LOAD patient groups we investigated the levels of diacylglycerols and ethanolamine plasmalogens in larger cohorts of patients utilizing, high-resolution (0.2 to 2ppm mass error) mass spectrometry.ResultsFor the first time, our lipidomics data clearly stratify both MCI and LOAD subjects into 3 different patient cohorts within each clinical diagnosis. These include i) patients with lower circulating ethanolamine plasmalogen levels; ii) patients with augmented plasma diacylglycerol levels; and iii) patients with neither of these lipid alterations.ConclusionsThese represent the first serum biochemical data to stratify MCI and LOAD patients, advancing efforts to biochemically define patient heterogeneity in cognitive disorders.General significanceLipidomics offers a new approach for identifying biomarkers and biological targets in cognitive disorders

Instrumented measurement of glenohumeral joint laxity: reliability and normative data

This study assessed shoulder laxity using an instrumented arthrometer. We compared anterior and posterior translations at various force levels to determine the reliability of our measurement technique and to provide normative data in healthy shoulders. Fifty shoulders were assessed for glenohumeral joint laxity in two directions (anterior and posterior) and at four force levels (67, 89, 111, and 134 N). The dependent measure was joint displacement. Laxity values were widely, yet normally, distributed in our group of healthy shoulders. Intraclass correlation coefficients revealed excellent between-trial reliability (0.92) and fair between-session (0.73) and between-examiner (0.74) reliability. The average standard error of measurement between trials (0.56 mm), sessions (1.5 mm), and examiners (1.7 mm) demonstrated an unprecedentedly high degree of precision for quantifying glenohumeral joint laxity. Paired t tests revealed no significant laxity differences between sides ( P >0.05), indicating bilateral symmetry. A 2 (direction) × 4 (force) analysis of variance revealed significant differences in laxity between directions ( P <0.0001) and force levels ( P <0.0001). Our results show that our instrumented technique for quantifying glenohumeral joint laxity is precise and reproducible. Posterior translation was significantly greater than anterior, and a significant increase in translation was observed between increasing levels of force.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41911/1/167-9-1-34_s001670000174.pd

Produtividade e composição bromatológica de milho em sistema de plantio direto submetido a fontes de nitrogênio.

O nitrogênio é o nutriente mais absorvido e com maior influencia na produtividade de grãos para cultura do milho. O experimento foi realizado na FZEA/USP em Pirassununga-SP, com o cultivo de milho em sistema de plantio direto. O delineamento experimental foi em blocos completos casualizados com quatro repetições e dez tratamentos: testemunha + gesso, testemunha absoluta, uréia, uréia + gesso, uréia + sulfato de amônio (SAM), nitrato de amônio (NA), NA + gesso, NA + SAM, SAM e Fusion Amonium Sulfate Nitrate (FASN) com objetivo de avaliar a utilização do FASN determinando os parâmetros produtivos e bromatológicos. Os maiores rendimentos foram obtidos pelos tratamentos com NA, SAM, FASN e as combinações, uréia + gesso, uréia + SAM, que adicionados à combinação NA + SAM, obtiveram as maiores eficiências de uso do N, enquanto que, os dois tratamentos sem aplicação de N foram inferiores aos demais tratamentos. Para os parâmetros bromatológicos não houve diferença entre os tratamentos, assim, concluiu-se que o FASN pode ser utilizado para o cultivo de milho em sistema de plantio direto com eficiência e produtividade semelhante a fertilizantes nitrogenados tradicionais sem alteração dos parâmetros bromatológicos

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.

Oligomers comprised of misfolded proteins are implicated as neurotoxins in the pathogenesis of protein misfolding conditions such as Parkinson's and Alzheimer's diseases. Structural, biophysical, and biochemical characterization of these nanoscale protein assemblies is key to understanding their pathology and the design of therapeutic interventions, yet it is challenging due to their heterogeneous, transient nature and low relative abundance in complex mixtures. Here, we demonstrate separation of heterogeneous populations of oligomeric α-synuclein, a protein central to the pathology of Parkinson's disease, in solution using microfluidic free-flow electrophoresis. We characterize nanoscale structural heterogeneity of transient oligomers on a time scale of seconds, at least 2 orders of magnitude faster than conventional techniques. Furthermore, we utilize our platform to analyze oligomer ζ-potential and probe the immunochemistry of wild-type α-synuclein oligomers. Our findings contribute to an improved characterization of α-synuclein oligomers and demonstrate the application of microchip electrophoresis for the free-solution analysis of biological nanoparticle analytes

Ruminal methane emissions in grazing beef heifers.

Brazil is one of the largest beef exporter in the world, and this is due to the introduction of Nellore cattle which has been adapted to the edaphoclimatic conditions of the country. With more than 200 million head, distributed in different production managements, producing through mainly extensive grazing system, Brazil has the responsibility to increase its productivity. That means, to produce more in smaller areas using fewer animals. One option to achieve that goal is to make the rotational management, thus, it may provide a better control of food supply for animals. However, it is also necessary to be concerned about the environment, especially for the methane produced from enteric fermentation in rumen. The objective of this study was to measure the emission of enteric methane in beef heifers in rotational and continuous grazing systems