How flexible is cognitive control? (Mouse) tracking conflict adaptation across context similarities

Exerting cognitive control to remain on-task and reach our goals is a crucial skill, as is the ability to flexibly adapt our responding in rapidly changing environments. The dynamics of cognitive control are typically studied by examining how participants process stimuli that contain competing relevant and irrelevant information in so-called conflict tasks. Adjustments in performance following the experience of conflict, also termed conflict adaptation, suggests a certain degree of flexibility in the deployment of cognitive control. The present study investigated to what extent conflict adaptation effects transfer across trials of the same and different tasks in three online mouse-tracking experiments. Adaptations of the Simon and Stroop tasks were combined to create different levels of context similarity between the paired tasks. Based on a previous review (Braem et al., Frontiers in Psychology 5:1–13, 2014), across-task conflict adaptation was expected only in the most and least similar contexts. In contrast to our hypothesis, conflict adaptation effects were observed in at least one measure in all three experiments. To our surprise, task order also seemed to impact the size of across-task conflict adaptation effects. The heterogeneity in the current results highlight the importance of using sensitive measurement tools to evaluate conflict adaptation and suggest that the occurrence of across-task conflict adaptation may be conditional on more than just shared relevant and irrelevant dimensions

Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology

Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (HDC, SLITRK1, BTBD9, and SLC6A4) in an effort to identify possibly causal variants using a targeted re-sequencing approach by next generation sequencing technology. Identification of possible disease causing variants under different modes of inheritance was performed using the algorithms implemented in VAAST. We prioritized variants using Variant ranker and validated five rare variants via Sanger sequencing in HDC and SLITRK1, all of which are predicted to be deleterious. Intriguingly, one of the identified variants is in linkage disequilibrium with a variant that is included among the top hits of a genome-wide association study for response to citalopram treatment, an antidepressant drug with off-label use also in obsessive compulsive disorder. Our findings provide additional evidence for the implication of these two genes in TS susceptibility and the possible role of these proteins in the pathobiology of TS should be revisited

Psychopathic traits influence threat avoidance in a community sample independent of testosterone

Psychopathy is a personality construct that encompasses a constellation of traits reflecting emotional dysfunction and antisocial behavior. Individuals with elevated levels of psychopathic traits have shown abnormal affective processing. Studies with psychopathic offenders suggested that this is a result of altered automatic social approach-avoidance tendencies. The goal of the current study was to increase the insight into the underlying mechanism of affective processes in community-dwelling individuals with a high level of psychopathic traits by studying approach and avoidance behavior in an experimental setting. Furthermore, given its link with aggression and threat approach, testosterone was measured to investigate a possible mediatory role. Eighty-seven healthy individuals performed a computerized affective approach-avoidance task in which they pushed or pulled emotional faces using a joystick. The results showed that high levels of psychopathic traits corresponded with diminished threat avoidance to angry faces, as was found previously in psychopathic offenders. Although endogenous testosterone was positively associated with the level of psychopathic traits, it did not mediate the effect of psychopathic traits on threat avoidance. We propose that an increased understanding of the interplay between different neuroendocrine mechanisms could lead to a better insight into the underlying mechanism of abnormal threat avoidance in individuals with high levels of psychopathic traits. (PsycInfo Database Record (c) 2021 APA, all rights reserved)