934 research outputs found
A Missense Mutation in the Collagen Triple Helix of EDA Is Associated with X-Linked Recessive Hypohidrotic Ectodermal Dysplasia in Fleckvieh Cattle.
Mutations within the ectodysplasin A (EDA) gene have been associated with congenital hypotrichosis and anodontia (HAD/XHED) in humans, mice, dogs and cattle. We identified a three-generation family of Fleckvieh cattle with male calves exhibiting clinical and histopathological signs consistent with an X-linked recessive HAD (XHED). Whole genome and Sanger sequencing of cDNA showed a perfect association of the missense mutation g.85716041G>A (ss2019497443, rs1114816375) within the EDA gene with all three cases following an X-linked recessive inheritance, but normal EDAR and EDARADD. This mutation causes an exchange of glycine (G) with arginine (R) at amino acid position 227 (p.227G>R) in the second collagen triple helix repeat domain of EDA. The EDA variant was associated with a significant reduction and underdevelopment of hair follicles along with a reduced outgrowth of hairs, a complete loss of seromucous nasolabial and mucous tracheal and bronchial glands and a malformation of and reduction in number of teeth. Thermostability of EDA G227R was reduced, consistent with a relatively mild hair and tooth phenotype. However, incisors and canines were more severely affected in one of the calves, which correlated with the presence of a homozygous missense mutation of RNF111 (g.51306765T>G), a putative candidate gene possibly associated with tooth number in EDA-deficient Fleckvieh calves
Extracting the Proton ubar content from pp->Direct Photon plus Jet Cross Sections
An analysis procedure is proposed to measure the antiquark distributions in
the proton over the region 0.01 < x < 0.1. The procedure involves the
measurement of high p_t asymmetric direct photon and jet final states in pp
interactions. This measurement can be made at the RHIC collider running in pp
mode at an energy of sqrt(s)=500 GeV/c. This analysis identifies a region of
phase space where the contribution from quark-antiquark annihilation
uncharacteristically approaches the magnitude of the contribution from the
leading process, quark-gluon Compton scattering. The forward-backward angular
asymmetry in the parton center of mass is sensitive to the antiquark content of
the proton and the ubar parton density function can be extracted.Comment: 21 pages, 7 figure
Measurement of quasi-elastic 12C(p,2p) scattering at high momentum transfer
We measured the high-momentum quasi-elastic 12C(p,2p) reaction (at center of
mass angle near 90 degrees) for 6 and 7.5 GeV/c incident protons. The
three-momentum components of both final state protons were measured and the
missing energy and momentum of the target proton in the nucleus were
determined.
The validity of the quasi-elastic picture was verified up to Fermi momenta of
about 450 MeV/c, where it might be questionable. Transverse and longitudinal
Fermi momentum distributions of the target proton were measured and compared to
independent particle models which do not reproduce the large momentum tails. We
also observed that the transverse Fermi distribution gets wider as the
longitudinal component increases in the beam direction, in contrast to a simple
Fermi gas model.Comment: 4 pages including 3 figure
Sum Rule Description of Color Transparency
The assumption that a small point-like configuration does not interact with
nucleons leads to a new set of sum rules that are interpreted as models of the
baryon-nucleon interaction. These models are rendered semi-realistic by
requiring consistency with data for cross section fluctuations in proton-proton
diffractive collisions.Comment: 22 pages + 3 postscript figures attache
Spin Structure of the Pion in a Light-Cone Representation
The spin structure of the pion is discussed by transforming the wave function
for the pion in the naive quark model into a light-cone representation. It is
shown that there are higher helicity () states in
the full light-cone wave function for the pion besides the ordinary helicity
() component wave functions as a consequence from
the Melosh rotation relating spin states in light-front dynamics and those in
instant-form dynamics. Some low energy properties of the pion, such as the
electromagnetic form factor, the charged mean square radius, and the weak decay
constant, could be interrelated in this representation with reasonable
parameters.Comment: 15 Latex pages, 2 figures upon reques
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Bulk properties of the system formed in Au+Au collisions at sNN =14.5 GeV at the BNL STAR detector
We report systematic measurements of bulk properties of the system created in Au+Au collisions at sNN=14.5 GeV recorded by the STAR detector at the Relativistic Heavy Ion Collider (RHIC). The transverse momentum spectra of π±, K±, and p(p) are studied at midrapidity (|y|<0.1) for nine centrality intervals. The centrality, transverse momentum (pT), and pseudorapidity (η) dependence of inclusive charged particle elliptic flow (v2), and rapidity-odd charged particles directed flow (v1) results near midrapidity are also presented. These measurements are compared with the published results from Au+Au collisions at other energies, and from Pb+Pb collisions at sNN=2.76 TeV. The results at sNN=14.5 GeV show similar behavior as established at other energies and fit well in the energy dependence trend. These results are important as the 14.5-GeV energy fills the gap in μB, which is of the order of 100 MeV, between sNN=11.5 and 19.6 GeV. Comparisons of the data with UrQMD and AMPT models show poor agreement in general
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Measurements of the transverse-momentum-dependent cross sections of J /ψ production at mid-rapidity in proton+proton collisions at s =510 and 500 GeV with the STAR detector
We present measurements of the differential cross sections of inclusive J/ψ meson production as a function of transverse momentum (pTJ/ψ) using the μ+μ- and e+e- decay channels in proton+proton collisions at center-of-mass energies of 510 and 500 GeV, respectively, recorded by the STAR detector at the Relativistic Heavy Ion Collider. The measurement from the μ+μ- channel is for
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