15 research outputs found
ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy in borderline-resected pancreatic cancer
Radiation therapy (RT) is a valuable component of multimodal treatment for localized pancreatic cancer.
Intraoperative radiation therapy (IORT) is a very precise RT modality to intensify the irradiation effect for
cancer involving upper abdominal structures and organs, generally delivered with electrons (IOERT).
Unresectable, borderline and resectable disease categories benefit from dose-escalated chemoradiation
strategies in the context of active systemic therapy and potential radical surgery. Prolonged preoperative
treatment may act as a filter for selecting patients with occult resistant metastatic disease. Encouraging
survival rates have been documented in patients treated with preoperative chemoradiation followed by
radical surgery and IOERT (>20 months median survival, >35% survival at 3 years). Intensive preoperative
treatment, including induction chemotherapy followed by chemoradiation and an IOERT boost, appears
to prolong long-term survival within the subset of patients who remain relapse-free for>2 years
(>30 months median survival; >40% survival at 3 years). Improvement of local control through higher
RT doses has an impact on the survival of patients with a lower tendency towards disease spread.
IOERT is a well-accepted approach in the clinical scenario (maturity and reproducibility of results), and
extremely accurate in terms of dose-deposition characteristics and normal tissue sparing. The technique
can be adapted to systemic therapy and surgical progress. International guidelines (National
Comprehensive Cancer Network or NCCN guidelines) currently recommend use of IOERT in cases of close
surgical margins and residual disease. We hereby report the ESTRO/ACROP recommendations for performing IOERT in borderline-resectable pancreatic cancer
The effect of a standardized premedication on oxygen saturation in the cardiac patient before transfer to the operating room
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Deformation of Alpha-Emitting Nuclei from Spin Alignment With the Spin Spectrometer
The Spin Spectrometer was used to measure the angular distribution of alpha particles with respect to the spin direction of residual nuclei from fusion of 176-MeV /sup 20/Ne with /sup 150/Nd. The results show an enhancement of the ratio of 90/sup 0/ to 0/sup 0/ alpha yields with respect to spin direction with decreasing E/sub ..cap alpha../ at subbarrier energies. This effect is not reproduced by statistical-model calculation made with transmission coefficients for spherical potentials, which may indicate that the ..cap alpha..-emitting nuclei are deformed with their longest axis perpendicular to the spin direction. 15 references
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Research highlights with the spin spectrometer
The excitation energy and angular momentum dependence of the entry states in fusion reactions measured with the spin spectrometer is discussed. A new decay mode involving the onset of localized stretched dipole radiation at half the accompanying stretched E2 collective radiation is found in /sup 157 -161/Yb. The appearance of this mode correlates smoothly with neutron number and spin. Possible interpretations are presented in terms of the evolution of the nuclear shapes from prolate to aligned-quasiparticle oblate to collective oblate and then to triaxial. Evidence for nuclear deformation that increases with spin at very high excitation is presented based on ..cap alpha..-particle angular distributions measured relative to the spin direction, using a new method for deriving the spin alignment
The spin spectrometer: Design, instrumentation and response characteristics of 4πγ-ray multidetector system
ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy in borderline-resected pancreatic cancer
Radiation therapy (RT) is a valuable component of multimodal treatment for localized pancreatic cancer.
Intraoperative radiation therapy (IORT) is a very precise RT modality to intensify the irradiation effect for
cancer involving upper abdominal structures and organs, generally delivered with electrons (IOERT).
Unresectable, borderline and resectable disease categories benefit from dose-escalated chemoradiation
strategies in the context of active systemic therapy and potential radical surgery. Prolonged preoperative
treatment may act as a filter for selecting patients with occult resistant metastatic disease. Encouraging
survival rates have been documented in patients treated with preoperative chemoradiation followed by
radical surgery and IOERT (>20 months median survival, >35% survival at 3 years). Intensive preoperative
treatment, including induction chemotherapy followed by chemoradiation and an IOERT boost, appears
to prolong long-term survival within the subset of patients who remain relapse-free for>2 years
(>30 months median survival; >40% survival at 3 years). Improvement of local control through higher
RT doses has an impact on the survival of patients with a lower tendency towards disease spread.
IOERT is a well-accepted approach in the clinical scenario (maturity and reproducibility of results), and
extremely accurate in terms of dose-deposition characteristics and normal tissue sparing. The technique
can be adapted to systemic therapy and surgical progress. International guidelines (National
Comprehensive Cancer Network or NCCN guidelines) currently recommend use of IOERT in cases of close
surgical margins and residual disease. We hereby report the ESTRO/ACROP recommendations for performing IOERT in borderline-resectable pancreatic cancer